Heteroarylation of unactivated C–H bonds suitable for late-stage functionalization

The late-stage introduction of diverse heterocycles onto complex small molecules enables efficient access to new medicinally relevant compounds. An attractive approach to such a transformation would utilize the ubiquitous aliphatic C–H bonds of a complex substrate. Herein, we report a system that enables direct C–H heteroarylation using a stable, commercially available O-alkenylhydroxamate with heterocyclic sulfone partners. The C–H heteroarylation proceeds efficiently with a range of aliphatic substrates and common heterocycles, and is a rare example of heteroarylation of strong C–H bonds. Importantly, the present approach is amenable to late-stage functionalization as the substrate is the limiting reagent in all cases.

The late-stage introduction of diverse heterocycles onto complex small molecules enables efficient access to new medicinally relevant compounds.     

Molecular structural analysis of 55mol% CuI-45mol% Ag2MoO4 solid electrolyte using XPS and laser raman techniques

The solid electrolyte 55 mol% CuI - 45 mol% Ag₂MoO₄ has been analyzed structurally by employing X-ray photoelectron spectroscopic (XPS) and laser Raman studies. The core level Ag 3d, Cu 2p, Mo 3d, I 3d and O1s XPS spectra of the constituent elements were recorded. The presence of both bridging (BO) and non-bridging (NBO) oxygen atoms in the oxyanion framework has been identified through the deconvolution of the O 1s spectrum. Laser Raman spectroscopic studies tend to reveal that the oxyanion framework is constructed with [MoO ₄ ²⁻ ]-tetrahedral and [MoO₆]-octahedral units as in the case of CuI - Cu₂MoO₄ and AgI - Ag₂O - MoO₃ glasses.     

Inelastic proton scattering from Ba and Sm at 30 MeV

Measurements of the inelastic scattering of 30 MeV protons from ¹³⁸Ba and ¹⁴⁴Sm have been carried out with 7–10 keV energy resolution. Differential cross sections were measured for levels up through 3.4 MeV excitation energy. For most of these states J^π assignments are suggested on the basis of angular distributions distinctly characteristic of angular momentum transfer L = 2, 3, 4,or 6.