Measuring technique for thermal ionisation mass spectrometry of human tracer kinetic study with stable cerium isotopes

Thermal ionisation mass spectrometry (TIMS) method has been developed for the simultaneous detection of different cerium isotopes in biological samples (i.e., blood and urine) at very low concentrations. The work has been done in the frame of a biokinetic study, where different stable cerium isotopes have been administered orally and intravenously as tracers to the human body. In order to develop an appropriate detection method for the tracers in the biological samples, an optimum sample preparation technique has been set and adapted to the specific requirements of the analysis technique used, i.e., TIMS. For sample evaporation and ionisation, the double tantalum filament technique showed the best results. The ions produced were simultaneously collected on a secondary electron multiplier so that the isotopic ratios of the cerium isotopes in the biological samples could be measured. The technique has been optimised for the determination of cerium down to 1?ng loaded on the evaporation filament corresponding to cerium concentrations of down to 1?ng?ml(-1) in the blood or urine samples. It has been shown that the technique is reliable in application and enables studies on cerium metabolism and biokinetics in humans without employing radioactive tracers.     

Stability of benzoporphyrin photosensitizers in water/ethanol mixtures: pKa determination and self‐aggregation processes

Benzoporphyrin monoacid derivatives, here named B3A and B3B, are promising new drugs for photodynamic therapy. Although both isomers show interesting characteristics as photosensitizing compounds, they have some distinct physicochemical properties such as the tendency to self‐aggregate in water‐rich media. Because pH drives the presence of each species, the pK_a of these compounds assumes strategic importance. However, traditional micro‐titration methods and UV–Vis absorption techniques fail to give reliable pK_a values due to the characteristics of this highly complex system, such as the precipitation of hydrophobic species, close pK_a values, and high absorption band superposition. In the present work, chemometric tools are employed to evaluate pK_a, and the kinetic tendency of monomers to undergo self‐aggregation is investigated. In solvent mixtures at low water percentage in ethanol, both B3A and B3B are stabilized in a monomeric state. However, in mixtures with a high water content, self‐aggregation takes place, mainly under a mild pH acid condition (3 < pH < 6), in which the prevalent protolytic species of both isomers is the neutral charged form, compounds with carboxylic and porphyrin free‐base groups. It is demonstrated that both isomers can undergo aggregation following a self‐catalytic mechanism, which is 2000 times slower to B3A than B3B. For B3A, the aggregation is manifested by a decrease in the monomer band with the aggregation band probably superposed to that of the monomer. For B3B, together with the decrease in the monomer band, a new band related to self‐aggregates is observed. Copyright © 2010 John Wiley & Sons, Ltd.     

On Some Classical Methods to Improve Algebraic Curves and Surfaces

First, a modern presentation of the theory of the Halphen transform is given. This method associates to a plane projective curve C, once a general conic has been chosen, another birationally equivalent plane curve, whose singularities are simpler than those of C. Repeating, a curve is obtained whose only singularities are nodes. Next, it is studied how to apply this process to a family of plane curves. With this technique it is possible to transform a given family (with irreducible general member) into one where, generically, the curves are nodal. Finally, it is studied a similar process, called the Halphen–Picard transformation, for surfaces in three-space. By suitably reiterating this procedure, a surface can be transformed into a birationally equivalent one (in the same projective space), such that the sections with planes in a general pencil are, generically, nodal curves.     

Arithmetic families of smooth surfaces and equisingularity of embedded schemes

This article deals with the foundations of a theory of equisingularity for families of zero-dimensional sheaves of ideals on smooth algebraic surfaces, in the arithmetic context, i.e., where one works with schemes defined over Dedekind rings. Here, different equisingularity conditions are analyzed and compared, based on one of the following requirements: 1) each member of the the family has the same desingularization tree, 2) the family admits a simultaneous desingularization, 3) a naturally associated family of curves is equisingular. Similar conditions had been investigated, in the context of Complex Local Analytic Geometry, by J. J. Risler. Received: 17 November 1997 / Revised version: 19 April 1999     

Heuristic algorithms for a vehicle routing problem with simultaneous delivery and pickup and time windows in home health care

This paper addresses a vehicle scheduling problem encountered in home health care logistics. It concerns the delivery of drugs and medical devices from the home care company’s pharmacy to patients’ homes, delivery of special drugs from a hospital to patients, pickup of bio samples and unused drugs and medical devices from patients. The problem can be considered as a special vehicle routing problem with simultaneous delivery and pickup and time windows, with four types of demands: delivery from depot to patient, delivery from a hospital to patient, pickup from a patient to depot and pickup from a patient to a medical lab. Each patient is visited by one vehicle and each vehicle visits each node at most once. Patients are associated with time windows and vehicles with capacity. Two mixed-integer programming models are proposed. We then propose a Genetic Algorithm (GA) and a Tabu Search (TS) method. The GA is based on a permutation chromosome, a split procedure and local search. The TS is based on route assignment attributes of patients, an augmented cost function, route re-optimization, and attribute-based aspiration levels. These approaches are tested on test instances derived from existing VRPTW benchmarks.     

Synthesis and characterization of cellulose acetate from cellophane industry residues. Application as acetaminophen controlled-release membranes

Journal of Thermal Analysis and Calorimetry - Cellophane film production generates cellulosic residues from scraps, edges, and low-quality films. In this work, cellophane was used as a raw material...     

Edge-enhanced imaging with polyvinyl alcohol/acrylamide photopolymer gratings

We demonstrate edge-enhanced imaging produced by volume phase gratings recorded on a polyvinyl alcohol/acrylamide photopolymer. Bragg diffraction, exhibited by volume gratings, modifies the impulse response of the imaging system, facilitating spatial filtering operations with no need for a physical Fourier plane. We demonstrate that Kogelnik's coupled-wave theory can be used to calculate the transfer function for the transmitted and the diffracted orders. The experimental and simulated results agree, and they demonstrate the feasibility of our proposal.     

Refinements of the Weyl Pure Geometrical Thick Branes From Information‐Entropic Measure

This work aims to analyse the so‐called configurational entropy in the Weyl pure geometrical thick brane model. The Weyl structure plays a prominent role in the brane thickness of this model. We find a set of parameters associated to the brane width where the configurational entropy exhibits critical points. The information‐theoretical measure sets bounds into parameter of Weyl pure geometrical brane model. In addition, we also argue that a similar approach can be useful to analyze the corrections to Newtonian and Coulombian potentials in Weyl scenarios.     

Plant-Derived Pesticides as an Alternative to Pest Management and Sustainable Agricultural Production: Prospects,Applications and Challenges

Pests and diseases are responsible for most of the losses related to agricultural crops, either in the field or in storage. Moreover, due to indiscriminate use of synthetic pesticides over the years, several issues have come along, such as pest resistance and contamination of important planet sources, such as water, air and soil. Therefore, in order to improve efficiency of crop production and reduce food crisis in a sustainable manner, while preserving consumer’s health, plant-derived pesticides may be a green alternative to synthetic ones. They are cheap, biodegradable, ecofriendly and act by several mechanisms of action in a more specific way, suggesting that they are less of a hazard to humans and the environment. Natural plant products with bioactivity toward insects include several classes of molecules, for example: terpenes, flavonoids, alkaloids, polyphenols, cyanogenic glucosides, quinones, amides, aldehydes, thiophenes, amino acids, saccharides and polyketides (which is not an exhaustive list of insecticidal substances). In general, those compounds have important ecological activities in nature, such as: antifeedant, attractant, nematicide, fungicide, repellent, insecticide, insect growth regulator and allelopathic agents, acting as a promising source for novel pest control agents or biopesticides. However, several factors appear to limit their commercialization. In this critical review, a compilation of plant-derived metabolites, along with their corresponding toxicology and mechanisms of action, will be approached, as well as the different strategies developed in order to meet the required commercial standards through more efficient methods.