Some features of formation of an inclusion complex ofβ-cyclodextrin with rhodamine 6G

Results of an investigation of the influence of the process of complex formation on the spectral and luminescence characteristics of aqueous solutions of inclusion complexes of β-cyclodextrin with rhodamine 6G are reported. It is shown that complex formation of rhodamine 6G proceeds mainly in the outer sphere of β-cyclodextrin. To whom correspondence should be addressed. B. I. Stepanov Institute of Physics, National Academy of Sciences of Belarus, 68, F. Skorina Ave., Minsk, 220072, Belarus. Translated from Zhurnal Prikladnoi Spektroskopii, Vol. 66, No. 5, pp. 619–621, September–October, 1999.     

Laser-induced photodissociation of oxyhemoglobin: Optical method of elimination of hypoxia (oxygen deficiency in biotissue)

We consider the effect of laser-induced in vivo photodissociation of blood oxyhemoglobin on gas exchange in biological tissues. An optical method of laser-induced oxygenation of biotissues is developed and proposed. We show that, in the region of the action of the laser radiation, the degree of oxygenation of a tissue increases. We experimentally confirm that the phenomenon of laser-induced in vivo photodissociation of oxyhemoglobin opens up a new possibility of controlling the local concentration of free molecular oxygen in tissues, eliminating tissue hypoxia, and stimulating aerobic metabolism of cells. We show that the efficiency of the proposed method of laser-induced oxygenation of biotissues proves to be comparable with the efficiency of the hyperbaric oxygenation, but has the advantage of the locality of the action. The proposed optical method of local oxygenation of biotissues will make it possible to eliminate the problem of hypoxia in cancerous tumor tissue and to considerably increase the efficiency of photodynamic, radiation, and chemotherapy in modern oncology.