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Anita M. R. Fisher Kathleen Danenberg Debabrata Banerjee Joseph R. Bertino Peter Danenberg Charles J. Gomer 《Photochemistry and photobiology》1997,66(2):265-270
Loss of p53 function has been correlated with decreased sensitivity to chemotherapy and radiation therapy in a variety of human tumors. Comparable analysis of p53 status with sensitivity to oxidative stress induced by pho-todynamic therapy has not been reported. In the current study we examined photosensitivity in human promye-locytic leukemia HL60 cells exhibiting either wild-type p53, mutated p53 or deleted p53 expression. Experiments were performed using a purpurin, tin ethyl etiopurpurin (SnET2)-, or a porphyrin, Photofrin (PH)-based photo-sensitizer. Total SnET2 accumulation was comparable in all three cell lines. Uptake of PH was highest in cells expressing wild-type p53 but incubation conditions could be adjusted to achieve equivalent cellular PH levels during experiments that analyzed photosensitivity. Survival measurements demonstrated that HL60 cells expressing wild-type p53 were more sensitive to PH- and SnET2-mediated photosensitization, as well as to UVC irradiation, when compared to HL60 cells exhibiting deleted or mutated p53 phenotypes. A rapid apoptotic response was observed following purpurin- and porphyrin-induced photosensitization in all cell lines. Results of this study indicate that photosensitivity is increased in HL60 cells expressing wild-type p53 and that photosensitizer-medi-ated oxidative stress can induce apoptosis through a p53-independent mechanism in HL60 cells . 相似文献
13.
Ying Chen Anita E. Tavakley Tate M. Mathiason T. Andrew Taton 《Journal of polymer science. Part A, Polymer chemistry》2006,44(8):2604-2614
Photocrosslinkable poly(vinylbenzophenone)‐containing polymers were synthesized via a one‐step, Friedel–Crafts benzoylation of polystyrene‐containing starting materials [including polystyrene, polystyrene‐block‐poly(tert‐butyl acrylate), polystyrene‐block‐poly(ethylene oxide), polystyrene‐block‐poly(methyl methacrylate), and polystyrene‐block‐poly(n‐butyl acrylate)] with benzoyl trifluoromethanesulfonate as a benzoylation reagent. The use of this mild reagent (which required no added Lewis acid) permitted polymers with well‐defined compositions and narrow molecular weight distributions to be synthesized. Micelles formed from one of these benzoylated polymers, [polystyrene0.25‐co‐poly(vinylbenzophenone)0.75]115‐block‐poly(acrylic acid)14, were then fixed by the irradiation of the micelle cores with UV light. As the irradiation time was increased, the pendent benzophenone groups crosslinked with other chains in the glassy micelle cores. Dynamic light scattering, spectrofluorimetry, and Fourier transform infrared spectroscopy were all used to verify the progress of the crosslinking reaction. © 2006 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 44: 2604–2614, 2006 相似文献
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Triorganotin(IV) and triorganolead(IV) derivatives of the types Me3Sn(SCZ) and Ph3Pb(SCZ) (where SCZ? is the anion of a semicarbanzone ligand) have been synthesized by substitution reactions of trimethyltin chloride and triphenyl-lead chloride with semicarbazones derived from heterocyclic ketones. The resulting complexes have been characterized by elemental analyses, molecualr weight determinations and conductivity measurements. The mode of bonding has been established on the basis of infrared and 1H, 13C and 119Sn NMR spectroscopic studies. Some respresentative complexes have also been evaluated for their antimicrobial effects on different species of pathogenic fungi and bacteria; the results of these investigations have been reported in the present paper. 相似文献
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Excess volumes V
E
of binary liquid mixtures of quinoline with alkanols have been determined from densities at 30°C as a function of composition. The excess volumes are negative over the whole mole fraction range for all the mixtures and decrease with increasing length of alkanol (C1–C10). The VE data have been analyzed in terms of an approach which uses graph theoretical connectivity parameters of the third degrees for two components. The analysis gives information regarding associated species in the pure state and in the mixture. It is suggested that, in the mixture state, no change occurs in the association of alkanols. 相似文献
18.
The transformation of gibbsite have been studied under hydrothermal influence. Results of the X-ray diffraction analysis of the samples heated at different temperatures from 170°C to 265°C are also discussed in detail. The percentage of the boehmite phase formed, due to the transformation of the gibbsite, have been determined by comparing the intensity of the most strongest reflection of the boehmite phase with a fully transformed sample. The activation energy value calculated form X-ray diffractograms is almost comparable with the value calculated from main DTA endotherm of gibbsite.Es wurde die Umwandlung von Gibbsit unter hydrothermalem Einfluß untersucht. Weiterhin werden auch Ergebnisse der Röntgendiffraktionsanalyse an den bei verschiedenen Temperaturen zwischen 170°C und 265°C erhitzten Proben besprochen. Durch Vergleich der Intensität der stärksten Reflexion der Böhmitphase mit einer vollständig umgewandelten Probe wurde der prozentuelle Anteil der während der Umwandlung von Gibbsit gebildeten Böhmitphase bestimmt. Der Wert für die Aktivierungsenergie, berechnet aus den Röntgendiffraktogrammen ist annähernd vergleichbar mit dem aus der DTA von Gibbsit berechneten Wert.
RRL Contribution No. 2028. 相似文献
RRL Contribution No. 2028. 相似文献
19.
Kinetics of oxidation of lactose, maltose, cellobiose and melibiose has been studied by hexacyanoferrate(III) in the presence of ammonia. A general mechanism involving the formation of intermediate enodiol anion has been suggested. The effects of dielectric constant and salts have been studied in detail. The oxidation products have been characterised by descending paper chromatography. Compensation effects have been observed. 相似文献
20.
The ESCA spectrum of protonated 1,8-bis-(dimethylamino) naphthalene (“proton sponge”) (I) has been recorded in the region of N1s binding energies. The results indicate that IH+ possesses an unsymmetrical N? H…?N hydrogen bridge. 相似文献