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991.
A Dual Photoredox- and Cp2TiCl2-Catalyzed Approach for the Direct Access to α-Vinyl-β-hydroxy Esters
Emanuele Pinosa Prof. Andrea Gualandi Dr. Andrea Fermi Prof. Paola Ceroni Prof. Pier Giorgio Cozzi Dr. Francesco Calogero 《European journal of organic chemistry》2023,26(38):e202300421
For the first time, a dual photoredox- and titanocene-catalyzed methodology for the regioselective access to α-vinyl-β-hydroxy esters towards aldehyde allylation with 4-bromobut-2-enoate is reported. The protocol is based on the Barbier-type properties of the inexpensive and available Cp2TiCl2 in catalytic amount (5 mol%). The developed mild reaction conditions gave access to a library of differently functionalized α-vinyl-β-hydroxy esters in moderate diastereoselectivity, employing the commercially available ethyl 4-bromobut-2-enoate and both aromatic and aliphatic aldehydes. The reaction was realized under visible light irradiation, in the presence of an organophotocatalyst (3DPAFIPN, 2 mol%) combined with Hantzsch's ester as the sacrificial reductant. In contrast to other Barbier-type reactions employing ethyl 4-bromobut-2-enoate, the photoredox system ensures a better regioselectivity. Moreover, the use of preformed organometallic nucleophilic species (e. g., dienolborinates), and the need of metal reductants or stoichiometric amount of transition metals in low oxidation state for Barbier-type reactions, is avoided. To support the experimental evidence, a detailed photophysical study shed light on the mechanism of the reaction. 相似文献
992.
Miriam Calabrese Andrea Pizzi Roberta Beccaria Antonio Frontera Giuseppe Resnati 《Chemphyschem》2023,24(16):e202300298
Single crystal X-ray diffraction of iodate and bromate salts shows that the I and Br atoms in IO3− and BrO3− anions form short and linear O−I/Br ⋅⋅⋅ O contacts with the O atoms of nearby anions. Non-centrosymmetric systems are formed wherein anions are orderly aligned into supramolecular 1D and 2D networks. Theoretical evidences, namely the outcome of QTAIM and NCIplot studies, prove the attractive nature of these contacts and the ability of iodate and bromate anions to act as robust halogen bond (HaB) donors. The HaB is proposed as a general and effective assisting tool to control the architecture of acentric iodate salts. 相似文献
993.
Structural Polymorphism and Thin Film Transistor Behavior in the Fullerene Framework Molecule 5,6;11,12‐di‐o‐Phenylenetetracene 下载免费PDF全文
Dipl.‐Ing. Tobias Wombacher Dr. Andrea Gassmann Sabine Foro Prof. Heinz von Seggern Prof. Dr. Jörg J. Schneider 《Angewandte Chemie (International ed. in English)》2016,55(20):6041-6046
The molecular structure of the hydrocarbon 5,6;11,12‐di‐o‐phenylenetetracene (DOPT), its material characterization and evaluation of electronic properties is reported for the first time. A single‐crystal X‐ray study reveals two different motifs of intramolecular overlap with herringbone‐type arrangement displaying either face‐to‐edge or co‐facial face‐to‐face packing depicting intensive π–π interactions. Density functional theory (DFT) calculations underpin that a favorable electronic transport mechanism occurs by a charge hopping process due to a π‐bond overlap in the DOPT polymorph with co‐facial arene orientation. The performance of polycrystalline DOPT films as active organic semiconducting layer in a state‐of‐the‐art organic field effect transistor (OFET) device was evaluated and proves to be film thickness dependent. For 40 nm layer thickness it displays a saturation hole mobility (μhole) of up to 0.01 cm2 V?1 s?1 and an on/off‐ratio (Ion/Ioff) of 1.5×103. 相似文献
994.
Dr. Irene Tosi Dr. Mireia Segado Centellas Dr. Elisa Campioli Dr. Alessandro Iagatti Dr. Andrea Lapini Dr. Cristina Sissa Prof. Laura Baldini Prof. Chiara Cappelli Dr. Mariangela Di Donato Prof. Francesco Sansone Dr. Fabrizio Santoro Prof. Francesca Terenziani 《Chemphyschem》2016,17(11):1686-1706
In this work, the dynamics of electronic energy transfer (EET) in bichromophoric donor–acceptor systems, obtained by functionalizing a calix[4]arene scaffold with two dyes, was experimentally and theoretically characterized. The investigated compounds are highly versatile, due to the possibility of linking the dye molecules to the cone or partial cone structure of the calix[4]arene, which directs the two active units to the same or opposite side of the scaffold, respectively. The dynamics and efficiency of the EET process between the donor and acceptor units was investigated and discussed through a combined experimental and theoretical approach, involving ultrafast pump–probe spectroscopy and density functional theory based characterization of the energetic and spectroscopic properties of the system. Our results suggest that the external medium strongly determines the particular conformation adopted by the bichromophores, with a direct effect on the extent of excitonic coupling between the dyes and hence on the dynamics of the EET process itself. 相似文献
995.
We prove weighted \({L^p}\)-Liouville theorems for a class of second-order hypoelliptic partial differential operators \({\mathcal{L}}\) on Lie groups \({\mathbb{G}}\) whose underlying manifold is \({n}\)-dimensional space. We show that a natural weight is the right-invariant measure \(\check{H}\) of \({\mathbb{G}}\). We also prove Liouville-type theorems for \({C^{2}}\) subsolutions in \({L^{p}(\mathbb{G},\check{H})}\). We provide examples of operators to which our results apply, jointly with an application to the uniqueness for the Cauchy problem for the evolution operator \({\mathcal{L}-\partial_{t}}\). 相似文献
996.
Davide Masoero Andrea Raimondo Daniele Valeri 《Communications in Mathematical Physics》2016,344(3):719-750
We study the ODE/IM correspondence for ODE associated to \({\widehat{\mathfrak{g}}}\)-valued connections, for a simply-laced Lie algebra \({\mathfrak{g}}\). We prove that subdominant solutions to the ODE defined in different fundamental representations satisfy a set of quadratic equations called \({\Psi}\)-system. This allows us to show that the generalized spectral determinants satisfy the Bethe Ansatz equations. 相似文献
997.
The nonlinear programming problem of finding the minimum covering ball of a finite set of points in \(\mathbb {R}^n\), with a positive weight corresponding to each point, is solved by a directional search method. At each iteration, the search path is either a ray or the arc of a circle and is determined by bisectors of points. Each step size along the search path is determined explicitly. The primal algorithm is shown to search along the farthest point Voronoi diagram of the given points. We provide computational results that show the efficiency of the algorithm when compared to general convex nonlinear optimization solvers. 相似文献
998.
We state some recent results concerning liquid-vapor phase transitions for a fluid flow through a porousmedium. The focus is on the friction exerted by the porous medium, which is modeled in such a way to include both laminar and turbulent flows. In this way we obtain a hyperbolic system of three balance laws with a forcing term that is discontinuous in the state variables. Existence, uniqueness and qualitative behavior of traveling waves is proved by a novel regularization technique. 相似文献
999.
Lucas N. Alberca María L. Sbaraglini Darío Balcazar Laura Fraccaroli Carolina Carrillo Andrea Medeiros Diego Benitez Marcelo Comini Alan Talevi 《Journal of computer-aided molecular design》2016,30(4):305-321
Chagas disease is a parasitic infection caused by the protozoa Trypanosoma cruzi that affects about 6 million people in Latin America. Despite its sanitary importance, there are currently only two drugs available for treatment: benznidazole and nifurtimox, both exhibiting serious adverse effects and limited efficacy in the chronic stage of the disease. Polyamines are ubiquitous to all living organisms where they participate in multiple basic functions such as biosynthesis of nucleic acids and proteins, proliferation and cell differentiation. T. cruzi is auxotroph for polyamines, which are taken up from the extracellular medium by efficient transporters and, to a large extent, incorporated into trypanothione (bis-glutathionylspermidine), the major redox cosubstrate of trypanosomatids. From a 268-compound database containing polyamine analogs with and without inhibitory effect on T. cruzi we have inferred classificatory models that were later applied in a virtual screening campaign to identify anti-trypanosomal compounds among drugs already used for other therapeutic indications (i.e. computer-guided drug repositioning) compiled in the DrugBank and Sweetlead databases. Five of the candidates identified with this strategy were evaluated in cellular models from different pathogenic trypanosomatids (T. cruzi wt, T. cruzi PAT12, T. brucei and Leishmania infantum), and in vitro models of aminoacid/polyamine transport assays and trypanothione synthetase inhibition assay. Triclabendazole, sertaconazole and paroxetine displayed inhibitory effects on the proliferation of T. cruzi (epimastigotes) and the uptake of putrescine by the parasite. They also interfered with the uptake of others aminoacids and the proliferation of infective T. brucei and L. infantum (promastigotes). Trypanothione synthetase was ruled out as molecular target for the anti-parasitic activity of these compounds. 相似文献
1000.
Zhiqian?Yang Monica?Argenziano Paolina?Salamone Elisa?Pirro Andrea?E.?Sprio Federica?Di Scipio Maria?E.?Carere Elena?Quaglino Federica?Cavallo Roberta?Cavalli Giovanni?N.?BertaEmail author 《Journal of inclusion phenomena and macrocyclic chemistry》2016,86(3-4):263-271
Trans-Resveratrol (RV) is a natural polyphenol characterized by interesting pleiotropic potentials and health benefits, but its administration is hampered by a unsatisfactory pharmacokinetics. Various approaches have been identified to circumvent it: among them, 2-hydroxypropyl-β-cyclodextrins (HPβCD) are valuable strategy. Here, we compare the employment of HPβCD based formulation with a resveratrol nanosupension (obtained by diluting a RV ethanol solution with PBS, added of 0.05 % hydroxyethylcellulose) to improve RV bioavailability after oral administration to mice. The inclusion of RV in HPβCD was confirmed by differential scanning calorimetry, Fourier transformed infrared spectroscopy, and phase solubility study. The two formulations were orally administered to BALB-c mice. RV concentrations in plasma and tissues were detected at different time (0–120 min) by HPLC method. HPβCD complexation mediate a approximately fourfold increment in plasma RV Cmax and approximately twofold augment of RV AUC0-120 in comparison with RV nanosuspension. Similar increased concentrations were observed in heart, liver, kidney and gut. In particular, HPβCD mediated a 5.5-folds increase of resveratrol concentration in the intestine, in comparison to the nanosuspension. In conclusion, based on our results, HPβCD complexation is a promising approach to increase the oral bioavailability of RV. Moreover, the achievement of high concentrations in gut suggested a potential employment of oral RV-HPβCD as anti-inflammatory/chemopreventive agent in this tissue. 相似文献