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991.
Davide Masoero Andrea Raimondo Daniele Valeri 《Communications in Mathematical Physics》2016,344(3):719-750
We study the ODE/IM correspondence for ODE associated to \({\widehat{\mathfrak{g}}}\)-valued connections, for a simply-laced Lie algebra \({\mathfrak{g}}\). We prove that subdominant solutions to the ODE defined in different fundamental representations satisfy a set of quadratic equations called \({\Psi}\)-system. This allows us to show that the generalized spectral determinants satisfy the Bethe Ansatz equations. 相似文献
992.
The nonlinear programming problem of finding the minimum covering ball of a finite set of points in \(\mathbb {R}^n\), with a positive weight corresponding to each point, is solved by a directional search method. At each iteration, the search path is either a ray or the arc of a circle and is determined by bisectors of points. Each step size along the search path is determined explicitly. The primal algorithm is shown to search along the farthest point Voronoi diagram of the given points. We provide computational results that show the efficiency of the algorithm when compared to general convex nonlinear optimization solvers. 相似文献
993.
We state some recent results concerning liquid-vapor phase transitions for a fluid flow through a porousmedium. The focus is on the friction exerted by the porous medium, which is modeled in such a way to include both laminar and turbulent flows. In this way we obtain a hyperbolic system of three balance laws with a forcing term that is discontinuous in the state variables. Existence, uniqueness and qualitative behavior of traveling waves is proved by a novel regularization technique. 相似文献
994.
Lucas N. Alberca María L. Sbaraglini Darío Balcazar Laura Fraccaroli Carolina Carrillo Andrea Medeiros Diego Benitez Marcelo Comini Alan Talevi 《Journal of computer-aided molecular design》2016,30(4):305-321
Chagas disease is a parasitic infection caused by the protozoa Trypanosoma cruzi that affects about 6 million people in Latin America. Despite its sanitary importance, there are currently only two drugs available for treatment: benznidazole and nifurtimox, both exhibiting serious adverse effects and limited efficacy in the chronic stage of the disease. Polyamines are ubiquitous to all living organisms where they participate in multiple basic functions such as biosynthesis of nucleic acids and proteins, proliferation and cell differentiation. T. cruzi is auxotroph for polyamines, which are taken up from the extracellular medium by efficient transporters and, to a large extent, incorporated into trypanothione (bis-glutathionylspermidine), the major redox cosubstrate of trypanosomatids. From a 268-compound database containing polyamine analogs with and without inhibitory effect on T. cruzi we have inferred classificatory models that were later applied in a virtual screening campaign to identify anti-trypanosomal compounds among drugs already used for other therapeutic indications (i.e. computer-guided drug repositioning) compiled in the DrugBank and Sweetlead databases. Five of the candidates identified with this strategy were evaluated in cellular models from different pathogenic trypanosomatids (T. cruzi wt, T. cruzi PAT12, T. brucei and Leishmania infantum), and in vitro models of aminoacid/polyamine transport assays and trypanothione synthetase inhibition assay. Triclabendazole, sertaconazole and paroxetine displayed inhibitory effects on the proliferation of T. cruzi (epimastigotes) and the uptake of putrescine by the parasite. They also interfered with the uptake of others aminoacids and the proliferation of infective T. brucei and L. infantum (promastigotes). Trypanothione synthetase was ruled out as molecular target for the anti-parasitic activity of these compounds. 相似文献
995.
Zhiqian?Yang Monica?Argenziano Paolina?Salamone Elisa?Pirro Andrea?E.?Sprio Federica?Di Scipio Maria?E.?Carere Elena?Quaglino Federica?Cavallo Roberta?Cavalli Giovanni?N.?BertaEmail author 《Journal of inclusion phenomena and macrocyclic chemistry》2016,86(3-4):263-271
Trans-Resveratrol (RV) is a natural polyphenol characterized by interesting pleiotropic potentials and health benefits, but its administration is hampered by a unsatisfactory pharmacokinetics. Various approaches have been identified to circumvent it: among them, 2-hydroxypropyl-β-cyclodextrins (HPβCD) are valuable strategy. Here, we compare the employment of HPβCD based formulation with a resveratrol nanosupension (obtained by diluting a RV ethanol solution with PBS, added of 0.05 % hydroxyethylcellulose) to improve RV bioavailability after oral administration to mice. The inclusion of RV in HPβCD was confirmed by differential scanning calorimetry, Fourier transformed infrared spectroscopy, and phase solubility study. The two formulations were orally administered to BALB-c mice. RV concentrations in plasma and tissues were detected at different time (0–120 min) by HPLC method. HPβCD complexation mediate a approximately fourfold increment in plasma RV Cmax and approximately twofold augment of RV AUC0-120 in comparison with RV nanosuspension. Similar increased concentrations were observed in heart, liver, kidney and gut. In particular, HPβCD mediated a 5.5-folds increase of resveratrol concentration in the intestine, in comparison to the nanosuspension. In conclusion, based on our results, HPβCD complexation is a promising approach to increase the oral bioavailability of RV. Moreover, the achievement of high concentrations in gut suggested a potential employment of oral RV-HPβCD as anti-inflammatory/chemopreventive agent in this tissue. 相似文献
996.
Ferrous Iron Binding Key to Mms6 Magnetite Biomineralisation: A Mechanistic Study to Understand Magnetite Formation Using pH Titration and NMR Spectroscopy 下载免费PDF全文
Dr. Andrea E. Rawlings Dr. Jonathan P. Bramble Andrea M. Hounslow Prof. Michael P. Williamson Dr. Amy E. Monnington Dr. David J. Cooke Dr. Sarah S. Staniland 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(23):7885-7894
Formation of magnetite nanocrystals by magnetotactic bacteria is controlled by specific proteins which regulate the particles’ nucleation and growth. One such protein is Mms6. This small, amphiphilic protein can self‐assemble and bind ferric ions to aid in magnetite formation. To understand the role of Mms6 during in vitro iron oxide precipitation we have performed in situ pH titrations. We find Mms6 has little effect during ferric salt precipitation, but exerts greatest influence during the incorporation of ferrous ions and conversion of this salt to mixed‐valence iron minerals, suggesting Mms6 has a hitherto unrecorded ferrous iron interacting property which promotes the formation of magnetite in ferrous‐rich solutions. We show ferrous binding to the DEEVE motif within the C‐terminal region of Mms6 by NMR spectroscopy, and model these binding events using molecular simulations. We conclude that Mms6 functions as a magnetite nucleating protein under conditions where ferrous ions predominate. 相似文献
997.
Benjamin A. Chalmers Hui Xing Sevan Houston Charlotte Clark Sussan Ghassabian Andy Kuo Benjamin Cao Andrea Reitsma Cody‐Ellen P. Murray Jeanette E. Stok Glen M. Boyle Carly J. Pierce Stuart W. Littler David A. Winkler Paul V. Bernhardt Cielo Pasay James J. DeVoss James McCarthy Peter G. Parsons Gimme H. Walter Maree T. Smith Helen M. Cooper Susan K. Nilsson John Tsanaktsidis G. Paul Savage Craig M. Williams 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2016,128(11)
998.
999.
Hai Liu Xiaoyang Li Julio Mulero Andrea Carbonaro Marc Short Jianye Ge 《Electrophoresis》2016,37(12):1659-1668
Y chromosome STR loci are used in forensics primarily for identification purposes by determining the male lineages. The Henan province in China has established a large Y‐STR (>200 000 profiles) database for criminal investigations. A large proportion of the Y‐STR profiles in the database were generated using either the Applied Biosystems Yfiler? or Yfiler? Plus PCR Amplification kits. The additional loci in the Yfiler Plus kit as compared to the Yfiler kit results in a concomitant cumulative mutation rate increase across the loci. Therefore, in those cases when two profiles have one to a few mismatched loci, it is difficult to determine if they are from the same lineage. In this study, 7405 unrelated male profiles were manually selected from the database. Analysis showed higher power of discrimination than the corresponding Yfiler haplotypes. Further, the distributions of the number of mismatched loci and the mismatched steps were generated for father‐son, grandfather‐grandson, uncle‐nephew, and cousins (i.e. one, two, three, and four meioses, respectively) by exhaustive pairwise comparison of the unrelated profiles using a dynamic programming approach. The same distributions were generated for unrelated pairs with mutation rates of the loci. With the distributions, the false negative and false positive rates were determined. Two Yfiler profiles with ≤2 mismatched loci or ≤2 steps are more likely from the same lineage than unrelated lineages, and two Yfiler Plus profiles with ≤4 mismatched loci or ≤5 mismatched steps are more likely from the same lineage. 相似文献
1000.