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Research on Chemical Intermediates - Single electron transfer-mediated photochemical reaction of C60 fullerene with simple bis-α-silyl tertiary alkyl/benzyl amines has been developed for the... 相似文献
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Ravindra D. Jadhav Hitesh D. Mistry Hashim Motiwala Kishorkumar S. Kadam Shivaji Kandre Amol Gupte Ashok K. Gangopadhyay Rajiv Sharma 《Journal of heterocyclic chemistry》2013,50(4):774-780
Hydroxy (tosyloxy) iodobenzene (HTIB), a hypervalent iodine reagent, has been extensively used for oxidative transformations. We have developed a one‐pot synthesis wherein aldoximes when reacted with alkynes in the presence of HTIB result in the direct formation of isoxazoles. This simple and straightforward reaction allows for ease of purification while leading to the formation of high purity 3,5‐disubstituted isoxazoles in moderate yields. 相似文献
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Clark DA Kulkarni AA Kalbarczyk K Schertzer B Diver ST 《Journal of the American Chemical Society》2006,128(49):15632-15636
To extend the versatility of the ruthenium carbene-promoted enyne metathesis, it was combined with an Ireland ester enolate Claisen rearrangement. This reaction sequence provided conjugated dienes of higher substitution pattern than that obtained through a cross-enyne metathesis alone. The Ireland-Claisen was conducted across both acyclic and cyclic dienes produced from cross-metathesis and methylene-free enyne metathesis, respectively. In the case of cyclodienes, the Ireland-Claisen rearrangement produced s-trans locked dienes which underwent mode-selective ene reaction. The tandem, sequential use of the Ireland-Claisen rearrangement also proved suitable for chirality transfer originating from chiral propargylic alcohols. Last, the tandem metathesis/Ireland-Claisen was utilized to access 4-substituted-3,5-cyclohexadiene diol derivatives, which are valuable chiral intermediates for natural product synthesis. The combination of this pericyclic reaction with a catalytic metathesis reaction extends the versatility of cross-metathesis since additional diene motifs can be accessed. 相似文献
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Sachin V. Bhilare Amol R. Deorukhkar Nitin B. Darvatkar Meghana S. Rasalkar Manikrao M. Salunkhe 《Journal of molecular catalysis. A, Chemical》2007,270(1-2):123-126
Heteropoly acid tungstophosphoric acid (H3PW12O40) was found to be an excellent catalyst for the synthesis of symmetrical diaryl sulfoxides. The reaction was carried out in various organic solvents or ionic liquids and under solventfree condition. The reaction exhibited better results in terms of the yield and rate under solventfree condition. The catalyst was efficiently recovered from the reaction mixture and reused. The highlighting features of the present protocol are short reaction times, high yields of the products, ambient conditions, and simple workup. 相似文献
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Janorkar AV Luo N Hirt DE 《Langmuir : the ACS journal of surfaces and colloids》2004,20(17):7151-7158
Polymer films can be tailored for a specific application by modifying their surface properties. In this study, linear and branched architectures were grafted to ethylene-acrylic acid (EAA) copolymer films using the so-called grafting from approach. Dicyclohexylcarbodiimide was used to activate the carboxylic acid functionality on the surface of the EAA copolymer film before reacting it with selected di- and tri-amine compounds. The carboxylic acid functionality was subsequently regenerated by reacting the amine-grafted film with succinic anhydride. These reaction steps were then repeated to create the linear and branched architectures on the EAA film surface. The film surface resulting from each reaction step was analyzed using attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy and contact angle measurements. A systematic analysis of the ATR-FTIR results was performed to estimate the average conversion of the reaction schemes and to explain the observed contact angle results. A significant reduction in water contact angle for the EAA film grafted with a branched architecture was observed. The EAA film grafted with a linear architecture showed a marginal reduction in water contact angle when ethanol was used as a solvent for ethylenediamine. When the solvent for ethylenediamine was changed to water, the contact angle decreased noticeably. However, analysis of control films showed that the reduction in the contact angles was due to the solvent treatment. In the case of branched architectures, such reduction in contact angle due to the solvent treatment was not observed. Several control experiments were performed to ensure that the reduction in the contact angles was in fact due to the grafted species and not due to exposure to various solvents used in the reaction scheme. 相似文献
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Amol Thakkar Veronika Chadimov Esben Jannik Bjerrum Ola Engkvist Jean-Louis Reymond 《Chemical science》2021,12(9):3339
Computer aided synthesis planning (CASP) is part of a suite of artificial intelligence (AI) based tools that are able to propose synthesis routes to a wide range of compounds. However, at present they are too slow to be used to screen the synthetic feasibility of millions of generated or enumerated compounds before identification of potential bioactivity by virtual screening (VS) workflows. Herein we report a machine learning (ML) based method capable of classifying whether a synthetic route can be identified for a particular compound or not by the CASP tool AiZynthFinder. The resulting ML models return a retrosynthetic accessibility score (RAscore) of any molecule of interest, and computes at least 4500 times faster than retrosynthetic analysis performed by the underlying CASP tool. The RAscore should be useful for pre-screening millions of virtual molecules from enumerated databases or generative models for synthetic accessibility and produce higher quality databases for virtual screening of biological activity.The retrosynthetic accessibility score (RAscore) is based on AI driven retrosynthetic planning, and is useful for rapid scoring of synthetic feasability and pre-screening of large datasets of virtual/generated molecules. 相似文献