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121.
[reaction: see text] The tandem intermolecular enyne metathesis between 1-alkynes and cyclopentene is reported, providing 2-substituted 1,3-cycloheptadienes. The success of the intermolecular reaction hinges on an appropriate balance between cycloalkene ring strain and reactivity of the alkyne. 相似文献
122.
Dr. Amol P. Amrute Jacopo De Bellis Dr. Michael Felderhoff Prof. Dr. Ferdi Schüth 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(23):6819-6847
The mechanochemical synthesis of nanomaterials for catalytic applications is a growing research field due to its simplicity, scalability, and eco-friendliness. Besides, it provides materials with distinct features, such as nanocrystallinity, high defect concentration, and close interaction of the components in a system, which are, in most cases, unattainable by conventional routes. Consequently, this research field has recently become highly popular, particularly for the preparation of catalytic materials for various applications, ranging from chemical production over energy conversion catalysis to environmental protection. In this Review, recent studies on mechanochemistry for the synthesis of catalytic materials are discussed. Emphasis is placed on the straightforwardness of the mechanochemical route—in contrast to more conventional synthesis—in fabricating the materials, which otherwise often require harsh conditions. Distinct material properties achieved by mechanochemistry are related to their improved catalytic performance. 相似文献
123.
Dr. Amol M. Vibhute Dr. Hideki Tamai Dana Logviniuk Prof. Dr. Peter G. Jones Prof. Dr. Micha Fridman Prof. Dr. Daniel B. Werz 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(41):10595-10600
Pseudaminic acid (Pse) is a significant prokaryotic monosaccharide found in important Gram-negative and Gram-positive bacteria. This unique sugar serves as a component of cell-surface-associated glycans or glycoproteins and is associated with their virulence. We report the synthesis of azidoacetamido-functionalized Pse derivatives as part of a search for Pse-derived metabolic labeling reagents. The synthesis was initiated with d -glucose (Glc), which served as a cost-effective chiral pool starting material. Key synthetic steps involve the conversion of C1 of Glc into the terminal methyl group of Pse, and inverting deoxyaminations at C3 and C5 of Glc followed by backbone elongation with a three-carbon unit using the Barbier reaction. Metabolic labeling experiments revealed that, of the four Pse derivatives, ester-protected C5 azidoacetamido-Pse successfully labeled cells of Pse-expressing Gram-positive and Gram-negative strains. No labeling was observed in cells of non-Pse-expressing strains. The ester-protected and C5 azidoacetamido-functionalized Pse is thus a useful reagent for the identification of bacteria expressing this unique virulence-associated nonulosonic acid. 相似文献
124.
If n is a non-negative integer, then denote by ∂-n
H
∞ the space of all complex-valued functions f defined on such that f, f
(1), f
(2),...,f
(n) belong to H
∞, with the norm
We prove bounds on the solution in the corona problem for ∂-n
H
∞. As corollaries, we obtain estimates in the corona theorem also for some other subalgebras of the Hardy space H
∞. 相似文献
125.
Niteen B. Patil Ranjit S. Atapalkar Dr. Subhash P. Chavan Dr. Amol A. Kulkarni 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(70):17695-17699
Herein we report for the first time, an advanced continuous flow synthesis of the blockbuster Leishmaniasis drug miltefosine from simple starting materials by a sequence involving four steps of chemical transformation including a continuous mechanochemical step. First three reaction steps were performed in simple tubular reactors in a telescopic mode, while in the last step the product precipitated from the 3rd step was used for a continuous mechanochemical synthesis of miltefosine. When compared to a typical batch protocol that takes 15 h, miltefosine was obtained in 58 % overall yield in flow synthesis mode at the laboratory scale in a total residence time 34 min at synthesis rate of 10 g/hr, which is sufficient to treat 4800 patients per day. 相似文献
126.
Varpe Bhushan D. Jadhav Shailaja B. Chatale Bandoo C. Mali Anil S. Jadhav Shravan Y. Kulkarni Amol A. 《Structural chemistry》2020,31(5):1675-1690
Structural Chemistry - Indole derivatives are reported in the literature for their excellent kinase inhibition activity, so understanding their structural requirement is important.... 相似文献
127.
Amol Sasane 《Complex Analysis and Operator Theory》2012,6(2):465-475
Let
\mathbb Dn:={z=(z1,?, zn) ? \mathbb Cn:|zj| < 1, j=1,?, n}{\mathbb {D}^n:=\{z=(z_1,\ldots, z_n)\in \mathbb {C}^n:|z_j| < 1, \;j=1,\ldots, n\}}, and let
[`(\mathbbD)]n{\overline{\mathbb{D}}^n} denote its closure in
\mathbb Cn{\mathbb {C}^n}. Consider the ring
Cr([`(\mathbbD)]n;\mathbb C) = {f:[`(\mathbbD)]n? \mathbb C:f is continuous and f(z)=[`(f([`(z)]))] (z ? [`(\mathbbD)]n)}C_{\rm r}(\overline{\mathbb{D}}^n;\mathbb {C}) =\left\{f: \overline{\mathbb{D}}^n\rightarrow \mathbb {C}:f \,\, {\rm is \,\, continuous \,\, and}\,\, f(z)=\overline{f(\overline{z})} \;(z\in \overline{\mathbb{D}}^n)\right\} 相似文献
128.
Nilesh P. Tale Amol V. Shelke Girdharilal B. Tiwari Prerana B. Thorat Nandkishor N. Karade 《Helvetica chimica acta》2012,95(5):852-857
A short total synthesis of rubrolides C and E has been achieved in four steps, using readily available 4‐methoxyacetophenone, 2‐bromoacetic acid, and the appropriate aromatic aldehyde, in 46 and 45% yield, respectively. Key reactions involved are α‐tosyloxylation of the aryl methyl ketone, intramolecular Wittig reaction, Knoevenagel condensation, and demethylation. 相似文献
129.
Patil AV Premaraban T Berthoumieu O Watts A Davis JJ 《Chemistry (Weinheim an der Bergstrasse, Germany)》2012,18(18):5632-5636
Bacteriorhodopsin, BR, is a natural, photoresponsive, biomolecule that has potential application in data storage, imaging and sensing. Being membrane-bound, however, it is coupled with metallic electronic surfaces only with some difficulty. We report herein a facile method to generate uniformly orientated, anchored and active monolayers of BR on metallic electrodes. In the present study, the cytoplasmic side of the BR is equipped with an engineered cysteine to achieve largely lipid-free, orientation-specific, highly stable, covalent immobilization on gold surfaces. By using non-invasive Kelvin probe force microscopy, it is possible to measure the light-induced proton accumulation at the extracellular protein surface at truly molecular scales. The intimate probe-BR interaction possible on lipid removal facilitates the detection of photoinduced surface potential switching substantially larger ((20.4 ± 7.5) mV) with functional single delipidated mutant BR trimers than for the wild-type protein. The proton pumping detected is also notably highly unidirectional with the orientated protein. 相似文献
130.
Kategaonkar Amol H. Sadaphal Sandip A. Shelke Kiran F. Kategaonkar Atul H. Shingate Bapurao B. Shingare Murlidhar S. 《中国化学》2010,28(2):243-249
A series of new ethyl 2‐(ethoxyphosphono)‐1‐cyano‐2‐(substituted tetrazolo[1,5‐a]quinolin‐4‐yl)ethanoate derivatives have been synthesized for the first time of tetrazolo[1,5‐a]quinoline derivatives. Elemental analysis, IR, 1H NMR, 13C NMR, 31P NMR and mass spectral data elucidated the structures of the all newly synthesized compounds. In vitro antimicrobial activities of synthesized compounds have been investigated against Gram‐positive Bacillus subtilis, Gram‐negative Escherichia coli and two fungi Candida albicans and Aspergillus niger in comparison with standard drugs. Significantly microbiological behavior of these newly synthesized derivatives possesses significant antibacterial and antifungal activity. 相似文献
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