3-Hydroxy-7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one and 3-hydroxy-6H-benzo[c]chromen-6-one act as on-off selective fluorescent sensors for Iron (III) under in vitro and ex vivo conditions

Regarding the abundant use of metals for different purposes, it becomes more critical from various scientific and technological perspectives to discover novel agents as selective probes for the detection of specific metals. In our previous studies, we have shown that aqueous solutions of natural urolithins (i.e., hydroxyl-substituted benzo[c]chromen-6-one derivatives) are selective Iron (III) sensors in fluorescence assays. In this study, we have extrapolated these findings to another coumarine compound (i.e., 3-Hydroxy-7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one) and compared the selective metal binding properties with Urolithin B (i.e., 3-Hydroxy-6H-benzo[c]chromen-6-one). Following the synthesis and structure identification studies, the fluorometric studies pointed out that the lactam group in the structure still persists to be the important scaffold for maintaining selective on-off sensor capacity that renders the compound a selective Iron (III) binding probe. Moreover, for the first time, fluorescence cellular imaging studies concomitant to cytotoxicity assays with the title compounds were also performed and the results displayed the cell-penetrative, safe, and fluorescent detectable characteristics of the compounds in neuroblastoma and glioblastoma cells through servings as intracellular Iron (III) on-off sensors.     

Human health-related properties of chromones: an overview

Abstract

Natural compounds occurring throughout the world are scientifically and practically valuable because of their unique and beneficial properties to control a wide range of disorders in the human body. Chromones are attracting increasing attention as novel therapeutic agents due to their effective bioactivities for human health. Accordingly, the present overview article was designed to scan the biological and pharmacological performance of chromones, including their anti-inflammatory, anticancer, anti-oxidant, and anti-microbial activities.     

Comparative analysis and multi-criteria optimization of a supercritical recompression CO2 Brayton cycle integrated with thermoelectric modules

Journal of Thermal Analysis and Calorimetry - Regarding the high expense of the exploiting energy from energy resources, each innovation or modification on the energy systems with the aim of...     

Fabrication of a Sensitive Biosensing System for Cu2+ ion Detection by Gold-Decorated Graphene Oxide Functionalized with Gly-Gly-His

Journal of Cluster Science - Incorporation of nanomaterials and nanostructures into sensors causes remarkable advances in device operation due to sensitivity, selectivity, multiplexed detection...     

Kinetics of heterogeneous photocatalytic degradation of reactive dyes in an immobilized TiO2 photocatalytic reactor

The photocatalytic degradation of two reactive dyes has been investigated by UV/TiO2/H2O2 using an immobilized TiO2 photocatalytic reactor. Reactive Blue 8 (RB 8) and Reactive Blue 220 (RB 220) textile dyes were used as model compounds. Photocatalytic degradation processes were performed using a 5-L solution containing dyes. The initial concentrations of dyes were 50 mg/L. The radiation source was two 15 W UV-C lamps. A batch mode immersion photocatalytic reactor was utilized. UV-vis and ion chromatography (IC) analyses were employed to obtain the details of the photodegradation of the selected dyes. Colored synthetic waters were completely decolorized in relatively short time after UV irradiation in the presence of various concentrations of hydrogen peroxide. Formate, acetate, oxalate, and glyoxylate anions were detected as dominant aliphatic intermediates where they were further oxidized slowly to CO2. The UV/TiO2/H2O2 process was able to oxidize the dyes with partial mineralization of carbon, nitrogen, and sulfur heteroatoms into CO2, NO3-, and SO4(2-), respectively. Kinetics analysis indicates that the photocatalytic decolorization rates of the dye can be approximated by a pseudo-first-order model. The UV/TiO2/H2O2 process proved to be capable of decolorization and mineralization of the reactive dyes (RB 8 and RB 220).     

Zr-Based MOFs with High Drug Loading for Adsorption Removal of Anti-Cancer Drugs: A Potential Drug Storage

A robust and highly water stable series of UiO-66-drived MOFs including UiO-66-NH₂, glycidyl methacrylate functionalized UiO-66-NH₂ (UiO-66-GMA) and ethylenediamine functionalized UiO-66-NH₂ (UiO-66-EDA) were synthesized solvothermally and studied their adsorption performances toward two anti-cancer drugs, methotrexate (MTX) and curcumin (CUR) in the case of overdose. It was found that functionalizing the surface of UiO-66-NH₂ nanoparticles with different functional groups remarkably changes the adsorption capacity and the ideal adsorption selectivity of MTX over CUR. Particularly, the UiO-66-EDA exhibited the highest adsorption capacities for both drugs, 540.78 and 423.85 mg/g for MTX and CUR, respectively, because of the strong interaction between drug molecules and adsorbent via hydrogen bonding due to the existence of different polar functional groups. The kinetics of drugs adsorption was investigated by three well-known kinetic models, which the output indicates that the adsorption of both drugs onto the synthesized MOFs follow the pseudo-second-order model. Moreover, it was found that the equilibrium adsorption results were well fitted with the Langmuir isotherm models, revealing that the adsorption of both drugs onto the synthesized MOFs is a monolayer adsorption process. Further investigation illustrated that the synthesized MOFs could be easily activated and reused after four successive adsorption–desorption cycles. The output of the present work is of main important for biomedical and environmental applications of MOFs as an outstanding adsorbent for adsorption removal of hazardous drugs from contaminated aqueous solutions.     

Antiproliferative Activity of Gold(I) N-Heterocyclic Carbene and Triphenylphosphine Complexes with Ibuprofen Derivatives as Effective Enzyme Inhibitors

A series of gold(I) complexes of ligand ibuprofen-alkynyl (but-3-yn-1-yl 2-(4-isobutylphenyl)propanoate, LE) with N-heterocyclic carbene (LC: 1,3-dimethylimidazol-2-ylidene) and triphenylphosphine (PPh₃) ligands with formula (LE)Au (LC) (complex 1 ) and (LE)Au (PPh₃) (complex 2 ) were synthesized and fully characterized by spectroscopic methods. In order to reveal the cytotoxicity mechanism, the interaction of complex 1 or 2 with cysteine (HCys) has been studied by experimental and density functional theory (DFT) methods. The compounds were investigated for their anticancer activity against MCF-7, MDAMB 231 breast cancer cells, HT-29 colon cancer cells and MCF-10A non-tumor breast cell line. The results were compared with cisplatin and auranofin as reference drugs. The complex 2 showed more cytotoxic activity than complex 1 . The complex 2 was 4.2, 3.7, and 1.7 fold more active than cisplatin against HT-29, MDA-MB-231, MCF-7 cancer cell lines, respectively. The inhibition of thioredoxin reductase of complexes 1 and 2 including cytosolic (TrxR1) and mitochondrial (TrxR2) thioredoxin reductase and also the inhibition of glutathione reductase (GR) were studied in detail. Moreover, the cellular uptake and reactive oxygen species (ROS) generation of compounds were investigated. Based on the DFT calculations a relationship between the σ-donor ability of the isolated ligands and cytotoxicity is suggested.     

Fourier transform infrared and Raman spectra, vibrational assignment and density functional theory calculations of naphthazarin

FT Raman and FTIR spectra of Naphthazarin (5,8-dihydroxy-1,4-naphthoquinone) and its deuterated analogue are recorded. Comparison between the spectra obtained by two techniques, a series of density functional theory (DFT) calculations and the spectral behavior upon deuteration were used for the assignment of the vibrational spectra of this compound. The calculated vibrational frequencies by the B3LYP, B3PW91, G96LYP, G96P86, and MPWLYP density functionals are generally consistent with the observed spectra. Infrared and Raman vibrational transitions predicted by B3LYP/6-311++G** are reported for the titled compound and its deuterated analogous and the assignments are discussed. All experimental and theoretical results support a relatively weak hydrogen bond in naphthazarin (NZ), compared with that in the enol form of normal beta-diketones. The observed nuOH/nuOD and gammaOH/gammaOD appear at about 3060/2220 and 790/560 cm(-1), respectively, which are consistent with the calculated hydrogen bond geometry and proton chemical shift results. Two bands at about 350 and 290 cm(-1) are assigned to the O...O stretching modes belong to A1 and B2 species, respectively.     

Evaluation of UiO‐66 metal organic framework as an effective sorbent for Curcumin's overdose

Metal organic frameworks (MOFs) UiO‐66 (UiO stands for University of Oslo) and NH₂‐UiO‐66 were prepared and characterized as sorbent (antidotal agents) for curcumin (CUR) adsorption. The structure of products were characterized by X‐ray powder diffraction (XRD), Field emission scanning electron microscopy (FESEM), thermogravimetric analysis (TGA), Attenuated Total Reflectance‐Fourier transform infrared spectroscopy (ATR‐FTIR), and N₂ adsorption–desorption measurements. FESEM showed NH₂‐UiO‐66 displayed symmetrical crystals with triangular base pyramid morphology, with the particle size around 100 nm and uniform size distribution. Adsorption capacities of CUR/MOFs with different mass ratios in the feed were investigated in the present study, and this investigation revealed that when the CUR/MOFs with mass ratio was around 0.4, the absorption capacity of NH₂‐UiO‐66 had tended to maximum. Although, functionalization reduced the specific surface area and free volume, introducing polar amine groups could improve the affinity of NH₂‐UiO‐66 respect to CUR. Kinetic studies showed that the kinetic data are well fitted with the pseudo‐ second‐order model. MTT assay revealed that MOFs at the concentration range of 0–560 μg/ml had no cytotoxic effect on the Human Foreskin Fibroblast normal cell line (HFF‐2). These results suggest that these MOFs could be safe as sorbent for adsorb CUR from the body.