Novel lanthanum sulfide–decorated zirconia nanohybrid for enhanced electrochemical oxygen evolution reaction

Journal of Solid State Electrochemistry - Metal sulfide and oxides have drawn interest as economical substitutes to noble metal catalysts due to their ability for oxygen evolution reaction (OER)...     

可压缩流场中气泡脉动数值模拟

在应用边界元方法对气泡动力学的研究中, 绝大多数模型是建立在不压缩势流理论基础之上, 针对可压缩流场中气泡运动特性的研究很少. 从波动方程出发, 分别在气泡运动前期和后期对波动方程进行简化, 得到气泡运动局部和全局简化方程, 采用双渐进方法对简化方程进行匹配, 提出了考虑流场可压缩性的非球状气泡运动模型. 该模型的计算结果与Prospertti 等的解析结果吻合很好, 气泡脉动最大半径和内部最大压力随气泡脉动逐渐减小. 基于该模型对比了自由场中药包爆炸考虑可压缩性与不考虑可压缩性的计算结果, 发现考虑可压缩性气泡射流速度较小, 随后基于该模型计算了刚性边界下气泡的运动特性.     

Hydromagnetic flow and heat transfer adjacent to a stretching vertical sheet with prescribed surface heat flux

The similarity solution for the problem of mixed convection boundary layer flow adjacent to a stretching vertical sheet in an incompressible electrically conducting fluid in the presence of a transverse magnetic field is presented. It is assumed that the sheet is stretched with a power-law velocity and is subjected to a variable surface heat flux. The governing partial differential equations are first transformed into a system of non-linear ordinary differential equations, before being solved numerically by the Keller-box method. The numerical results obtained are then compared with previously reported cases available in the literature as well as the series solution for certain values of parameters, to support their validity. The effects of the governing parameters on the flow field and heat transfer characteristics are obtained and discussed.     

Structure of 12Be: intruder d-wave strength at N=8

The breaking of the N=8 shell-model magic number in the 12Be ground state has been determined to include significant occupancy of the intruder d-wave orbital. This is in marked contrast with all other N=8 isotones, both more and less exotic than 12Be. The occupancies of the [FORMULA: SEE TEXT]orbital and the [FORMULA: SEE TEXT], intruder orbital were deduced from a measurement of neutron removal from a high-energy 12Be beam leading to bound and unbound states in 11Be.     

Structural and Kinetic Profiling of Allosteric Modulation of Duplex DNA Induced by DNA-Binding Polyamide Analogues

A combined structural and quantitative biophysical profile of the DNA binding affinity, kinetics and sequence-selectivity of hairpin polyamide analogues is described. DNA duplexes containing either target polyamide binding sites or mismatch sequences are immobilized on a microelectrode surface. Quantitation of the DNA binding profile of polyamides containing N-terminal 1-alkylimidazole (Im) units exhibit picomolar binding affinities for their target sequences, whereas 5-alkylthiazole (Nt) units are an order of magnitude lower (low nanomolar). Comparative NMR structural analyses of the polyamide series shows that the steric bulk distal to the DNA-binding face of the hairpin iPr-Nt polyamide plays an influential role in the allosteric modulation of the overall DNA duplex structure. This combined kinetic and structural study provides a foundation to develop next-generation hairpin designs where the DNA-binding profile of polyamides is reconciled with their physicochemical properties.     

Total Synthesis of (−)‐Salinosporamide A via a Late Stage C−H Insertion

The synthesis of (?)‐salinosporamide A, a proteasome inhibitor, is described. The synthesis highlights the assembly of a densely decorated pyrrolidinone core via an aza‐Payne/hydroamination sequence. Central to the success of the synthesis is a late‐stage C?H insertion reaction to functionalize a sterically encumbered secondary carbon. The latter functionalization leads to an enabling transformation where most of the prototypical strategies failed.     

Melatonin Induces Autophagy via Reactive Oxygen Species-Mediated Endoplasmic Reticulum Stress Pathway in Colorectal Cancer Cells

Even though an increasing number of anticancer treatments have been discovered, the mortality rates of colorectal cancer (CRC) have still been high in the past few years. It has been discovered that melatonin has pro-apoptotic properties and counteracts inflammation, proliferation, angiogenesis, cell invasion, and cell migration. In previous studies, melatonin has been shown to have an anticancer effect in multiple tumors, including CRC, but the underlying mechanisms of melatonin action on CRC have not been fully explored. Thus, in this study, we investigated the role of autophagy pathways in CRC cells treated with melatonin. In vitro CRC cell models, HT-29, SW48, and Caco-2, were treated with melatonin. CRC cell death, oxidative stress, and autophagic vacuoles formation were induced by melatonin in a dose-dependent manner. Several autophagy pathways were examined, including the endoplasmic reticulum (ER) stress, 5′–adenosine monophosphate-activated protein kinase (AMPK), phosphoinositide 3-kinase (PI3K), serine/threonine-specific protein kinase (Akt), and mammalian target of rapamycin (mTOR) signaling pathways. Our results showed that melatonin significantly induced autophagy via the ER stress pathway in CRC cells. In conclusion, melatonin demonstrated a potential as an anticancer drug for CRC.     

Hierarchical and relativistic models of the universe

The Treder and Barbour-Bertotti models of relativistic Lagrangians using only relative coordinates and velocities are compared in light of Leibnitz-Mach ideas. The plausible relationship between cosmological and vacuum asymmetries is noted, and the possibility of a modernized hierarchical model is discussed.Translated from Izvestiya Vysshikh Uchebnykh Zavedenii, Fizika, No. 7, pp. 86–90, July, 1978.     

Low-temperature synthesis of hexagonal barium ferrite (BaFe<Subscript>12</Subscript>O<Subscript>19</Subscript>) nanoparticles by annealing at 450 °C followed by quenching

Citrate precursor method has been used to obtain nanosized particles of barium hexaferrite at low temperatures. Samples were annealed at 450 °C for 3 and 5 h. Quenching of the third sample was done by taking the crucible out from the muffle furnace after annealing it for 5 h and putting it abruptly into an ice bath. The saturation magnetization has been found to be 4.36 and 0.04 emu g^?1 for the samples obtained upon annealing at 450 °C for 3 and 5 h, respectively, while that of the quenched sample has been found to be 4.61 emu g^?1. In case of the sample obtained after 5-h annealing, the squareness value was found to be maximum indicating significance in memory and switching applications. For the quenched and the 3-h annealing products, the magnetic data values are similar. Creation of spin disorders on the surface upon prolonged annealing, due to disappearance of oxygen ions and subsequent breakage of superexchange interactions between cations, has been undone upon quenching. The XRD and TEM data indicate that the particle size (9–17 nm) gets lower in case of the quenched samples. Photoluminescence study of the quenched sample furnished prominent peaks in UV, visible and near-IR regions under 200-nm excitation. The TG–DSC data were analysed for the kinetic parameters, activation energy (E), pre-exponential factor (A) using the Kissinger isoconversion and the Ozawa–Flynn–Wall methods for the first-step decomposition of the quenched sample.