Synthesis and Antiviral Properties against SARS-CoV-2 of Epoxybenzooxocino[4,3-b]Pyridine Derivatives

The COVID-19 pandemic is ongoing as of mid-2022 and requires the development of new therapeutic drugs, because the existing clinically approved drugs are limited. In this work, seven derivatives of epoxybenzooxocinopyridine were synthesized and tested for the ability to inhibit the replication of the SARS-CoV-2 virus in cell cultures. Among the described compounds, six were not able to suppress the SARS-CoV-2 virus’ replication. One compound, which is a derivative of epoxybenzooxocinopyridine with an attached side group of 3,4-dihydroquinoxalin-2-one, demonstrated antiviral activity comparable to that of one pharmaceutical drug. The described compound is a prospective lead substance, because the half-maximal effective concentration is 2.23 μg/μL, which is within a pharmacologically achievable range.     

Shallow Donors and Deep-Level Color Centers in Bulk AlN Crystals: EPR, ENDOR, ODMR and Optical Studies

The results of studies of shallow donors and deep-level color centers in bulk AlN crystals are presented. Two shallow donors (presumably oxygen located on the nitrogen site and carbon located on the aluminum site) are suggested to exhibit the DX-relaxation. Third shallow donor (presumably silicon on the Al site) shows the shallow donor behavior up to the room temperature and can be observed without light excitation at temperatures above 200 K. The values of the Bohr radius of the shallow donors are estimated. The structure of deep-level color centers (neutral nitrogen vacancy V _N) in bulk AlN crystals is determined and analyzed by electron paramagnetic resonance, electron-nuclear double resonance, optical absorption and thermoluminescence induced by X-ray irradiation. Spin-dependent recombination processes in AlN crystals are studied by means of optically detected magnetic resonance.     

Coding of Gibbs function flows from nucleotide pools

The biochemical machinery of living systems obeys kinetic laws, but is driven by Gibbs function flows. Both the kinetic and thermodynamic aspects of Gibbs gain, transmission, and utilization are considered. An information-theoretic approach is used to find conditions under which the kinetics encodes the associated Gibbs function flow with the lowest possible error.     

Determination of nanostructure of liposomes containing two model drugs by X‐ray scattering from a synchrotron source

Small‐angle X‐ray scattering has been employed to study how the introduction of paracetamol and acetylsalicylic acid into a liposome bilayer system affects the system's nanostructure. An X‐ray scattering model, developed for multilamellar liposome systems [Pabst et al. (2000), Phys. Rev. E, 62 , 4000–4009], has been used to fit the experimental data and to extract information on how structural parameters, such as the number and thickness of the bilayers of the liposomes, thickness of the water layer in between the bilayers, size and volume of the head and tail groups, are affected by the drugs and their concentration. Even though the experimental data reveal a complicated picture of the drug–bilayer interaction, they clearly show a correlation between nanostructure, drug and concentration in some aspects. The localization of the drugs in the bilayers is discussed.     

Impact of slow gain dynamics on soliton molecules in mode-locked fiber lasers

We theoretically demonstrate and experimentally confirm the major influence of gain dynamics on soliton molecules that self-assemble in mode-locked lasers. Both slow gain recovery and depletion play a pivotal role in the formation of chirped soliton molecules characterized by an increasing separation from leading to trailing pulses. These chirped molecules actually consist of many pulses and may be termed macromolecules. They are experimentally observed in a fiber laser and numerically modeled by an approach that properly includes the slow gain dynamics. Furthermore, it is shown that these processes stabilize soliton trains in fiber lasers by inhibiting internal oscillations.     

Chiodo formulas for the <Emphasis Type="Italic">r</Emphasis>-th roots and topological recursion

We analyze Chiodo’s formulas for the Chern classes related to the r-th roots of the suitably twisted integer powers of the canonical class on the moduli space of curves. The intersection numbers of these classes with \(\psi \)-classes are reproduced via the Chekhov–Eynard–Orantin topological recursion. As an application, we prove that the Johnson-Pandharipande-Tseng formula for the orbifold Hurwitz numbers is equivalent to the topological recursion for the orbifold Hurwitz numbers. In particular, this gives a new proof of the topological recursion for the orbifold Hurwitz numbers.     

Three-dimensional tracking of fluorescent nanoparticles with subnanometer precision by use of off-focus imaging

We show that the position of a fluorescent nanoparticle can be measured in three dimensions with subnanometer precision and 100-ms temporal resolution by use of standard epifluorescence video imaging in off-focus mode. The particle can be tracked without feedback in a volume of at least 40 microm x 60 microm x 3 microm. With the technique presented, the structure-mobility relationship of 216-nm latex particle in a porous polymer network was studied in three dimensions.     

Thermal expansion of Sn2P2S6 crystals

We present the results for thermal expansion coefficients of Sn₂P₂S₆ crystals determined both in the crystallographic system and the system based on eigenvectors of thermal expansion tensor. Peculiarities of temperature evolution of the indicative surface of thermal expansion tensor for Sn₂P₂S₆ are discussed, including the region of their ferroelectric phase transition.