Spectral and Mechanistic Investigation of Oxidation of Rizatriptan by Silver Third Periodate Complex in Aqueous Alkaline Medium

The oxidation of Rizatriptan by diperiodatoargentate(III) has been studied by spectrophotometry at neutral pH. The kinetics of the reaction of Rizatriptan has been shown to principle of non-complementary oxidation steps. The initial step involves the deprotonated of the diperiodatoargentate(III) with the alkali; this rearranges during the displacement of a ligand to give free periodate and takes up another ligand monoperiodateargentate(III), combines with a substrate to endow with an intermediate complex which decomposes within a slow step to provide the final product in the following step with a first-order rate constant. The main product was identified by spot test, Fourier- transform infrared spectroscopy, Nuclear magnetic resonance and Liquid chromatography-mass spectrometry spectrum. A conceivable mechanism including pre equilibrium of adducts development between the complex and reductant was planned from the kinetics study. The rate conditions got from system can clarify all exploratory phenomena, and the activation parameters alongside rate constants of the rate determining step were ascertained.     

Flower-shaped ZnO nanoparticles as an efficient, heterogeneous and reusable catalyst in the synthesis of N-arylhomophthalimides and benzannelated isoquinolinones

A simple and green protocol, developed utilizing an efficient, heterogeneous and recyclable catalyst, i.e. zinc oxide nanoparticles (ZnO NPs)-mediated synthesis of N-arylhomophthalimides and benzannelated isoquinolinones, is reported. The structures of the desired products were characterized by FTIR, ¹H NMR, ¹³C NMR, and HRMS techniques. The ZnO NPs exhibited excellent catalytic activity and the proposed methodology is capable of providing the desired products in good yield and purity.     

Synthesis,characterization, and electroanalytical studies of Pb2+-selective polypyrrole-Zr(IV) phosphate ion exchange membrane

Journal of Solid State Electrochemistry - Polypyrrole-Zr(IV) phosphate (PPyZP) composite cation exchange material was synthesized by chemical oxidative polymerization of pyrrole with the help of...     

Bioanalytical method development,validation and quantification of dorsomorphin in rat plasma by LC‐MS/MS

The present investigation describes the development and validation of a sensitive liquid chromatography–mass spectrometry/mass spectrometry (LC‐MS/MS) method for the estimation of dorsomorphin in rat plasma. A sensitive LC‐MS/MS method was developed using multiple reaction monitoring mode, with the transition of m/z (Q1/Q3) 400.2/289.3 for dorsomorphin and m/z (Q1/Q3) 306.2/236.3 for zaleplon. Chromatographic separation was achieved on a reverse phase Agilent XDB C₁₈ column (100 × 4.6 mm, 5 µm). The mobile phase consisted of acetonitrile and 5 mm ammonium acetate buffer (pH 6.0) 90:10 v/v, at a flow rate of 0.8 mL/min. The effluence was ionized in positive ion mode by electrospray ionization (ESI) and quantitated by mass spectrometry. The retention times of dorsomorphin and internal standard were found to be 2.13 and 1.13 min, respectively. Mean extraction recovery of dorsomorphin and internal standard in rat plasma was above 80%. Dorsomorphin calibration curve in rat plasma was linear (r² ≥ 0.99) ranging from 0.005 to 10 µg/mL. Inter‐day and intra‐day precision and accuracy were found to be within 85–115% (coefficient of variation). This method was successfully applied for evaluation of the oral pharmacokinetic profile of dorsomorphin in male Wistar rats. Copyright © 2013 John Wiley & Sons, Ltd.