Analysis of the reactivity of materials having two different kinds of functional groups using the A″-McKay plot method

The hydrogen-isotope exchange reaction between HTO vapor (as a gaseous material) andp-aminophenol (or -alanine) (as a solid material) having two different kinds of functional groups, has been studied to reveal the reactivity of the compounds. The reaction has been analyzed by the A-McKay plot method and the rate constants (k) for each group have been obtained. Comparison ofk leads to the following: (1) the effect of the NH₂ group inp-aminophenol on the reactivity is greater than that in -alanine, and (2) the reactivity of compounds having two different kinds of functional groups can be analyzed by the A-McKay plot method only.     

2-(8-quinolylazo)-7-phenylazochromotropic acid as an analytical reagent

2-(8-Quinolylazo)-7-phenylazochromotropic acid (QAPAC) has been synthesized by coupling diazotized 8-aminoquinoline with 2-phenylazochromotropic acid as well as by coupling diazotized aniline with 2-(8-quinolylazo)chromotropic acid. The properties of QAPAC and the spectrophotometric characteristics of some metal-QAPAC complexes are reported.     

Solid-liquid equilibrium diagrams of common ion binary salt hydrate mixtures involving nitrates and chlorides of magnesium, cobalt, nickel, manganese, and iron(III)

The solid-liquid equilibrium diagrams of binary mixtures involving magnesium nitrate hexahydrate with cobalt nitrate hexahydrate, nickel nitrate hexahydrate (partly), manganese nitrate tetrahydrate, and iron(III) nitrate nonahydrate and of magnesium chloride hexahydrate with cobalt and nickel chlorides hexahydrates and manganese chloride tetrahydrate, and the of two manganese salts were determined. Those diagrams that showed a simple eutectic were fitted by the Ott equation and where the required BET parameters were available, the magnesium salt rich parts of the liquidus were modeled by means of this method.     

Comparative pharmacokinetics of 67Ga among the different routes of injection

The pharmacokinetic study of 67Ga-citrate (67Ga) following intravenous (i.v.), subcutaneous (s.c.) and intraperitoneal (i.p.) injection was performed in anesthetized rats using the repeated blood sampling method by cannulation technique into the external jugular vein. The disappearance of 67Ga from the blood following i.v. and s.c. injection was best fit a three-exponential equation. There was no significant difference between the areas under the curves following i.v. and s.c. injection of 67Ga. In the case of i.p. injection, the disappearance of 67Ga from the blood was described by a two-exponential equation. However, the maximum blood radioactivity was very low, and the disappearance rate of 67Ga from the blood was extremely slow compared to the other routes of injection. The conclusion from these results was that s.c. injection was as suitable as i.v. injection, but i.p. injection was not appropriate for the distribution study of 67Ga such as scintigraphy or autoradiography. However, i.p. route may be available for a special experiment which needs the long-time retention of 67Ga in the blood.