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Mudassar Shahid Mohammad Raish Ajaz Ahmad Yousef A. Bin Jardan Mushtaq Ahmad Ansari Abdul Ahad Khalid M. Alkharfy Ahmed L. Alaofi Fahad I. Al-Jenoobi 《Molecules (Basel, Switzerland)》2022,27(13)
Background: Ulcerative colitis (UC) is a long-term condition which results in inflammation and ulcers of the colon and rectum. The key indications of active disease are abdominal pain and diarrhea mixed with blood. Aims: We explore the underlying colon protective mechanism of sinapic acid (SA) against acetic acid (AA) induced ulcerative colitis in rats. The implications of inflammation, oxidative stress, and apoptosis are studied. Methodology: Twenty-four rats were distributed into four categories, normal control (NC), ulcerative colitis (UC), ulcerative Colitis with SA 40 mg/kg (SA 40 mg/kg + AA), and ulcerative colitis with prednisolone (PRDL 10 mg/kg + AA), and were pretreated orally with saline, saline and SA (40 mg/kg/day) or PRDL (10 mg/kg/day) respectively, for 7 days. UC was prompted by trans-rectal administration of 4% AA on the 5th day, colon tissues were surgically removed for gross morphology and histological inspection, oxidative stress, and inflammatory markers and immunoblot analysis of Bax, caspase-3, and Bcl-2. Results: Macroscopic and histological inspection demonstrated that both SA 40 mg/kg and PRDL (10 mg/kg/day) significantly ameliorates colonic injuries. In addition, both pretreatments significantly ameliorates AA-induced UC, oxidative stress, as indicated by suppressed malondialdehyde (MDA), nitric oxide (NO) levels and restoring antioxidant/oxidant balance as indicated by catalase and glutathione levels, suppressed inflammation via inhibiting cytokines TNF-α, IL-6, inflammatory markers MPO, PGE2, COX-2 and NF-κB and inhibiting the protein expression of Bax and caspase-3 apoptotic protein and increasing the anti-apoptotic protein, Bcl-2 thereby inhibiting apoptosis. Conclusion: Sinapic acid significantly ameliorates AA induced UC in rats by suppressing inflammation, oxidative stress, and apoptosis in colonic tissues which exhibits its potential for the management of UC. 相似文献
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Ajaz Hussain Shagufta Perveen Abdul Malik Amna Nisar Khan Rasool Bakhsh Tareen 《Helvetica chimica acta》2010,93(6):1101-1104
Marrusidins A ( 1 ) and B ( 2 ), two new labdane‐type diterpenes, were isolated from the CHCl3‐soluble subfraction of Marrubium anisodon, along with polyodonine. Their structures were assigned with the aid of 1H‐ and 13C‐NMR spectra and by COSY, HMQC, NOESY, and HMBC experiments. 相似文献
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Choudhary MI Begum A Abbaskhan A Ajaz A Shafique-ur-Rehman Atta-ur-Rahman 《Chemical & pharmaceutical bulletin》2005,53(11):1469-1471
A phytochemical investigation on the aerial parts of Lindelofia stylosa has resulted in the isolation of seven phenyl propanoids. This includes three analogs of lithospermic acid, along with rosmarinic acid and its ester derivatives. Compound 1 was identified as a new natural product. These compounds were studied for their antioxidant properties. 相似文献
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Wazir Z. Gilani A. R. Suleymanov M. K. Ajaz M. Aslam S. M. Khattak S. A. Khan A. 《Physics of Particles and Nuclei Letters》2019,16(6):662-666
Physics of Particles and Nuclei Letters - We study the trend of transverse momentum (pT) and maximum transverse momentum (pTmax) distributions of pions and protons in He12C-interactions at 4.2A... 相似文献
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K. Mahmood A. Ali M. I. Arshad M. Ajaz un Nabi N. Amin S. Faraz Murtaza S. Rabia M. Azhar Khan 《Journal of Experimental and Theoretical Physics》2017,124(4):580-583
In this study, we demonstrate the optimization of the annealing temperature for enhanced thermoelectric properties of ZnO. Thin films of ZnO are grown on a sapphire substrate using the metal organic chemical Vapor Deposition (MOCVD) technique. The grown films are annealed in an oxygen environment at 600–1000°C, with a step of 100°C for one hour. Seebeck measurements at room temperature revealed that the Seebeck coefficient of the sample that was not annealed was 152 μV/K, having a carrier concentration of N D ~ 1.46 × 1018 cm–3. The Seebeck coefficient of the annealed films increased from 212 to 415 μV/K up to 900°C and then decreased at 1000°C. The power factor is calculated and found to have an increasing trend with the annealing temperature. This observation is explained by the theory of Johnson and Lark–Horovitz that thermoelectric properties are enhanced by improving the structure of ZnO thin films. The Hall measurements and PL data strongly justify the proposed argument. 相似文献
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Aiza Azam Gulzar Muhammad Muhammad Shahbaz Aslam Muhammad Mudassir Iqbal Muhammad Arshad Raza Naeem Akhtar Muhammad Ajaz Hussain Noreen Sajjad Asad Syed Ali H. Bahkali Zahid Shafiq 《应用有机金属化学》2023,37(1):e6923
The multifunctional zinc oxide nanoparticles are synthesized using a cost-effective, efficient, eco-friendly, simple, and clean synthesis approach. Herein, we reported the antibacterial and wound healing potential of zinc oxide nanoparticles (ZnO-NPs) prepared using psyllium gel (PG) as the reducing and stabilizing agent. The PG-mediated zinc oxide nanoparticles (PG-ZnO-NPs) were characterized using UV–Vis, photoluminescence (PL), FTIR, XRD, Raman, and SEM. UV–Vis spectral studies confirmed the surface plasmonic resonance (SPR) band at 364 nm. PL results demonstrated the fluorescent or emission nature of PG-ZnO-NPs. FTIR analysis confirmed characteristic peaks at 873.82 and 619.88 cm−1 due to the tetrahedral coordination of zinc and the formation of the Zn-O bond. XRD and Raman confirm the formation of PG-ZnO-NPs, whereas SEM analysis revealed PG-ZnO-NPs are rod-shaped, having hexagonal prism-like bases, and EDX exhibited the elemental composition of PG-ZnO-NPs. The as-synthesized PG-ZnO-NPs possessed prominent microbicidal potential against gram-positive (Bacillus subtilis and Bacillus licheniformis) and gram-negative (Escherichia coli and Salmonella shigella) bacterial strains in terms of zone of inhibition (ZOI), minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC). In vivo biological investigations with mice show that the synthesized PG-ZnO-NPs possess outstanding biocompatibility and wound healing potential. PG-ZnO-NPs dressing significantly speeds up full-thickness wound repair by triggering a decrease in MMP-1 and MMP-2 and escalating the mRNA levels of collagen types (I & III) and fibronectin. Thus, our work validates that the inclusion of PG-ZnO-NPs in dressing shows excellent potential for acute wound management. 相似文献