An efficient synthesis of fluorine-containing substituted spiro[piperidine-4,4′-pyrano[3,2-c]quinoline]-3′-carbonitrile by nonconventional methods

A series of fluorine-containing substituted spiro[piperidine-4,4′-pyrano[3,2-c]quinolines] were synthesized through a rapid one-pot multi-component reaction under microwave irradiation and sonication. The method has the advantages of excellent yields (80-96%) and short reaction time (3-10 min). We provide a series of fluorinated quinoline derivatives interesting for biological screening tests.     

First Example of Te-C Bond Cleaved Product in the Reaction of C8 H 8 TeI 2 with Ammonium Pipertidine Dithiocarbamate

Abstract

A series of 1,3-dihydro-2λ⁴-benzotellurole-2,2-diyl di-thiocarbamates C₈H₈TeR₂ and C₈H₈TeIR ( R═ S ₂CNC₅H₁₀, S₂CNHC₆H₅, S₂CNC₄H₈O) have been synthesised by the reactions of C8H8TeI₂ with the corresponding ammonium salts of piperidine-, aniline- and morpholine- dithiocarbamates in 1:1 and 1:2 molar ratio, respectively. They have been characterized by FT-IR and (¹H, ¹³C) NMR spectroscopy. The reaction of C₈H₈TeI₂ with (NH₄S₂CNC₅H₁₀) in 1:2 molar ratio gives C₈H₈Te(S₂CNC₅H₁₀)₂ [IR, (¹H, ¹³C)NMR evidence] and X-ray quality crystals of Te(S₂CNC₅H₁₀)₂ in very low yield, demonstrating the formation of the first Te–C bond-cleaved product.The monomers of Te(S₂CNC₅H₁₀)₂ are connected through intermolecular Te…S secondary bonds and it exists as a dimer in the solid state. These dimers are interconnected through intermolecular S…S secondary bonds to yield 3D-supramolecular network.     

Velogenic Newcastle Disease Virus as an Oncolytic Virotherapeutics: In Vitro Characterization

Cancer is one of the killer diseases in humans and needs alternate curative measures despite recent improvement in modern treatment modalities. Oncolytic virotherapy seems to be a promising nonconventional way to treat cancers. Newcastle disease virus (NDV), a poultry virus, is nonpathogenic to human and domestic animals and has a long history of being used in oncotherapy research in several preclinical studies. The ability of NDV to successfully infect and destroy cancer cells is dependent on the strain and the pathotype of the virus. Adaptation of viruses to heterologous hosts without losing its replicative and oncolytic potential is prerequisite for use as cancer virotherapeutics. In the present study, velogenic NDV was adapted for replication in HeLa cells, and its cytotoxic potential was evaluated by observing morphological, biochemical, and nuclear landmarks of apoptosis. Our results indicated that the NDV-induced apoptosis in HeLa cells was dependent on upregulation of TNF-related apoptosis-inducing ligand (TRAIL) and caspases activation. Different determinants of apoptosis evaluated in the present study indicated that this strain could be a promising candidate for cancer therapy in future.     

Evaluation of Techniques Used for Parameters Estimation: an Application to Bioremediation of Grease Waste

In the present work, evaluation of different conventional techniques, i.e., chemical oxygen demand (COD), biological oxygen demand, elemental analysis, Fourier transform infrared (FTIR), and gas chromatography used for estimating biodegradation of grease waste was carried out. In this order grease waste was incubated with Penicillium chrysogenum for 7?C30?days and analyzed percentage of degradation. After 15?days of incubation, the percentages of reduction in COD, carbon, hydrogen, and nitrogen content of grease waste were found 28, 53.5, 12.7, and 0, respectively. Further it was analyzed by FTIR and gas chromatography?Cmass spectroscopy (GC-MS) and observed that bifurcated peaks of grease waste at 2,926 and 2,855?cm^?1 had reduced remarkably, which corresponds to aliphatic hydrocarbons, while new broad peaks appeared at 3,400?cm^?1 indicating addition of oxygen molecule to reduced aliphatic hydrocarbon. GC-MS study also supports the results of FTIR, COD, and elemental analysis, but quantification of the percentage of degradation was difficult and limited to volatile organic content, while COD and elemental analysis were found more accurate and more informative. The current study would be helpful in the estimation of biodegradability not only of grease waste but also of other complex nonbiodegradable compounds polluting the environment.     

Synthesis and spectral studies of transition metal complexes with 1,5:11,15-dimetheno-2,4,10,12-tetramethyl-[1,5,9,13]-tetraazahexadeca-1,3,5,6,10,11,13,15,16,20-decene a sixteen-membered tetradentate macrocyclic ligand

Complexes of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Pd(II), Pt(II), Ru(III) and Ir(III) with a sixteen-membered 1,5:11,15-dimetheno-2,4,10,12-tetramethyl-[1,5,9,13]-tetraazahexadeca-1,3,5,6,10,11,13,15,16,20-decene macrocyclic ligand have been synthesized. These complexes are characterized by magnetic moment, infrared, electronic, EPR and mössbauer spectral studies. All of complexes were found to have six-coordinated octahedral geometry and are of the high spin type except for the Pd(II) and Pt(II) complexes which are four coordinate, square planar and diamagnetic.     

Synthesis of Amphiphilic RuII Heteroleptic Complexes Based on Benzo[1,2‐b:4,5‐b′]dithiophene: Relevance of the Half‐Sandwich Complex Intermediate and Solvent Compatibility

The detailed synthesis and characterization of four ruthenium(II) complexes [RuLL′(NCS)₂] is reported, in which L represents a 2,2′‐bipyridine ligand functionalized at the 4,4′ positions with benzo[1,2‐b:4,5‐b′]dithiophene derivatives (BDT) and L′ is 2,2′‐bipyridine‐4,4′‐dicarboxylic acid unit (dcbpy) (NCS=isothiocyanate). The reaction conditions were adapted and optimized for the preparation of these amphiphilic complexes with a strong lipophilic character. The photovoltaic performances of these complexes were tested in TiO₂ dye‐sensitized solar cell (DSSC) achieving efficiencies in the range of 3–4.5 % under simulated one sun illumination (AM1.5G).     

Aqueous electrolytes’ transport through nanopores of polymeric membrane

Ion permeation and the selectivity of sodium and potassium ions through the nanopores of polyethylene terephthalate (PET) have been investigated at room temperature using the conductometric technique. The nanopores in PET with the high aspect ratio have been created using the ion track technology. The passive (due to the concentration gradient) and active transport (due to the applied potential) of aqueous electrolytes (i.e.; NaClO₄ and KClO₄ and their different combinations) has been studied. Along with the effect of concentration and electric field gradient, the effect of anion accumulation outside the nanopores on the transport of electrolytes has also been analysed using time series and current–voltage measurements. The transportation and selection of ions also depends on the hydration energy of the ions. A detailed study of transport of ions through the nanopores explains their I–V and I–t behaviour due to the inter- and intra- molecular interaction and their effective interaction with the walls of the nanopores.     

The effect of infrared radiation on etching characteristics of CR-39 plastic track recorder

The effect of infrared radiation on the etching characteristics of CR-39 plastic track recorder has been studied. CR-39, which is commonly employed in cosmic rays studies is found to be affected by IR radiations. The changes in the bulk etch rate, in the track etch rate and in etching efficiency due to infrared radiation exposure of CR-39 are discussed on the basis of scission and cross linking during infrared exposure.     

Electrical and Optical Properties of O6+ Ion Beam–Irradiated Polymers

Variations in dielectric, optical, and structural properties of Lexan and Kapton-H irradiated to 80 MeV O⁶⁺ ion beam were analyzed at different fluences ranging from 10¹¹ to 10¹³ ions/cm² with a scanned beam current of 1 pnA. The structural modifications were characterized with the help of FT-IR and UV-vis spectroscopies. The electrical properties were investigated through capacitance and dielectric loss variations in ion-irradiated and pristine polymers at different frequencies. UV-vis absorption analysis indicates a decrease in the band gap energy in the two polymers. However, the decrease is much more prominent in Lexan (30%) than in Kapton-H (2.5%). The dielectric constant does not show appreciable variations after ion irradiation; however, a small increase has been noticed. An overall increase in the intensities of some typical bonds and stretching was observed in the FT-IR spectra of the pristine and ion-irradiated polymers.