全文获取类型
收费全文 | 98篇 |
免费 | 6篇 |
专业分类
化学 | 63篇 |
晶体学 | 2篇 |
力学 | 1篇 |
数学 | 20篇 |
物理学 | 18篇 |
出版年
2023年 | 1篇 |
2022年 | 4篇 |
2021年 | 6篇 |
2020年 | 1篇 |
2019年 | 2篇 |
2018年 | 3篇 |
2016年 | 1篇 |
2015年 | 7篇 |
2014年 | 3篇 |
2013年 | 7篇 |
2012年 | 6篇 |
2011年 | 6篇 |
2010年 | 5篇 |
2009年 | 4篇 |
2008年 | 9篇 |
2007年 | 5篇 |
2006年 | 4篇 |
2005年 | 1篇 |
2004年 | 6篇 |
2003年 | 2篇 |
2002年 | 2篇 |
2001年 | 1篇 |
2000年 | 3篇 |
1999年 | 4篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1994年 | 2篇 |
1993年 | 1篇 |
1992年 | 2篇 |
1989年 | 1篇 |
1985年 | 1篇 |
1982年 | 1篇 |
排序方式: 共有104条查询结果,搜索用时 93 毫秒
71.
Eduardo Díaz Hctor Barrios Rubn A. Toscano Francisco Yuste William F. Reynolds Jos Luis Aguilera Efrn Caballero 《Journal of heterocyclic chemistry》1992,29(5):1325-1330
The reaction of dibenzalacetones substituted on the aromatic ring with hydroxylamine hydrochloride and potassium hydroxide in refluxing ethanol affords several compounds. Herein, we report the structures and spectral properties of several oximes of 2-(4,5-dihydro-5-aryl-3-isoxazolyl)-1-arylethanones 6 . Unusual behaviour on its 1H-nmr and mass spectra was observed. Single crystal X-ray diffraction was performed on compound 6d to support our structural considerations abouth the title compounds. 相似文献
72.
Jana Brabcova Alicia Andreu David Aguilera Zaida Cabrera Blanca de las Rivas Rosario Muoz Jose M. Palomo 《Molecules (Basel, Switzerland)》2021,26(10)
Different materials containing carboxylic groups have been functionalized with geranyl-amine molecules by using an EDC/NHS strategy. Chemical modification of the support was confirmed by XRD, UV-spectrophotometer, and FT-IR. This geranyl-functionalized material was successfully applied for four different strategies of site-selective immobilization of proteins at room temperature and aqueous media. A reversible hydrophobic immobilization of proteins (lipases, phosphoglucosidases, or tyrosinase) was performed in neutral pH in yields from 40 to >99%. An increase of the activity in the case of lipases was observed from a range of 2 to 4 times with respect to the initial activity in solution. When chemically or genetically functionalized cysteine enzymes were used, the covalent immobilization, via a selective thiol-alkene reaction, was observed in the presence of geranyl support at pH 8 in lipases in the presence of detergent (to avoid the previous hydrophobic interactions). Covalent attachment was confirmed with no release of protein after immobilization by incubation with hydrophobic molecules. In the case of a selenium-containing enzyme produced by the selenomethionine pathway, the selective immobilization was successfully yielded at acidic pH (pH 5) (89%) much better than at pH 8. In addition, when an azido-enzyme was produced by the azide–homoalanine pathway, the selective immobilization was successful at pH 6 and in the presence of CuI for the click chemistry reaction. 相似文献
73.
New clostebol metabolites in human urine by liquid chromatography time‐of‐flight tandem mass spectrometry and their application for doping control
下载免费PDF全文
![点击此处可从《Journal of mass spectrometry : JMS》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Jianghai Lu María Fernández‐Álvarez Sheng Yang Genye He Youxuan Xu R. Aguilera 《Journal of mass spectrometry : JMS》2015,50(1):191-197
In this study, clostebol metabolic profiles were investigated carefully. Clostebol was administered to one healthy male volunteer. Urinary extracts were analyzed by liquid chromatography quadrupole time‐of‐flight mass spectrometry (MS) using full scan and targeted MS/MS techniques with accurate mass measurement for the first time. Liquid–liquid extraction and direct injection were applied to processing urine samples. Chromatographic peaks for potential metabolites were found by using the theoretical [M–H]? as target ion in full scan experiment, and their actual deprotonated ions were analyzed in targeted MS/MS mode. Fourteen metabolites were found for clostebol, and nine unreported metabolites (two free ones and seven sulfate conjugates) were identified by MS, and their potential structures were proposed based on fragmentation and metabolism pathways. Four glucuronide conjugates were also first reported. All the metabolites were evaluated in terms of how long they could be detected and S1 (4ξ‐chloro‐5ξ‐androst‐3ξ‐ol‐17‐one‐3ξ‐sulfate) was considered to be the long‐term metabolite for clostebol misuse detected up to 25 days by liquid–liquid extraction and 14 days by direct injection analysis after oral administration. Five conjugated metabolites (M2, M5, S2, S6 and S7) could also be the alternative biomarkers for clostebol misuse. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
74.
Ligand‐Assisted Gold‐Catalyzed Cross‐Coupling with Aryldiazonium Salts: Redox Gold Catalysis without an External Oxidant
下载免费PDF全文
![点击此处可从《Angewandte Chemie (International ed. in English)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Rong Cai Mei Lu Ellen Y. Aguilera Yumeng Xi Dr. Novruz G. Akhmedov Dr. Jeffrey L. Petersen Prof. Dr. Hao Chen Prof. Dr. Xiaodong Shi 《Angewandte Chemie (International ed. in English)》2015,54(30):8772-8776
Gold‐catalyzed C(sp)–C(sp2) and C(sp2)–C(sp2) cross‐coupling reactions are accomplished with aryldiazonium salts as the coupling partner. With the assistance of bpy ligand, gold(I) species were oxidized to gold(III) by diazonium without any external oxidants. Monitoring the reaction with NMR and ESI‐MS provided strong evidence for the nitrogen extrusion followed by AuIII reductive elimination as the key step. 相似文献
75.
76.
Michel Angelo Aguilera Francisco Jos Pea Oscar Andrs Negrete Patricio Vargas 《Entropy (Basel, Switzerland)》2022,24(2)
This present work explores the performance of a thermal–magnetic engine of Otto type, considering as a working substance an effective interacting spin model corresponding to the state clock model. We obtain all the thermodynamic quantities for the q = 2, 4, 6, and 8 cases in a small lattice size ( with free boundary conditions) by using the exact partition function calculated from the energies of all the accessible microstates of the system. The extension to bigger lattices was performed using the mean-field approximation. Our results indicate that the total work extraction of the cycle is highest for the case, while the performance for the Ising model () is the lowest of all cases studied. These results are strongly linked with the phase diagram of the working substance and the location of the cycle in the different magnetic phases present, where we find that the transition from a ferromagnetic to a paramagnetic phase extracts more work than one of the Berezinskii–Kosterlitz–Thouless to paramagnetic type. Additionally, as the size of the lattice increases, the extraction work is lower than smaller lattices for all values of q presented in this study. 相似文献
77.
Salomo Dos Santos Costa Juliana Pereira da Silva Matheus Moraes Biondo Edgar Aparecido Sanches Marcos Marques Da Silva Paula Francisco Xavier Nobre Jos Anglada Rivera Yohandys Alexis Zulueta Milton S. Torikachvili David Vieira Sampaio Marcos Vinicius Dias Vermelho tefan lu Lianet Aguilera Dominguez Yurimiler Leyet 《Molecules (Basel, Switzerland)》2022,27(18)
The temperature dependence of the electrical properties of composites formed by biphasic sodium titanate and poly(o-methoxyaniline) (Na2Ti3O7/Na2Ti6O13/POMA) with different concentrations of POMA (0%, 1%, 10%, 15%, 35% and 50%) in the ceramic matrix was determined from measurements of complex impedance. The structural details were studied by means of X-ray diffraction, confirming the formation of the Na2Ti3O7/Na2Ti6O13/POMA composites. The displacement of the (200) reflection from 2θ = 10.45° to 11.15° in the composites with 10 and 15% of POMA suggested the partial replacement of H+ for Na+ in the Na2Ti3O7 structure. The thermal properties were investigated by Thermogravimetry and Differential Thermal Analysis. The Thermogravimetry curves of the composites with POMA content of 1, 10 and 15% presented profiles similar to that of pure sodium titanate sample. The composites with 35 and 50% of POMA showed a process at temperatures around 60–70 °C, which was associated with water absorbed by the polymer. The analysis of the complex impedance spectroscopy measurements revealed that the electrical resistivity of the composites in the range from 0 to 35% increased by two orders of magnitude, with different values for each concentration. This positive temperature coefficient of resistivity was less noticeable in the composite with highest POMA mass content (50%). The rapid increase in resistivity caused an increase in the relaxation time calculated from the time domain. The electrical response of the 50% of POMA compound changes in relation to what was observed in the other compounds, which suggests that there is a saturation limit in the increase in resistivity with POMA content. 相似文献
78.
Aruna Chhikara Praveen K. Roayapalley Hiroshi Sakagami Shigeru Amano Keitaro Satoh Yoshihiro Uesawa Umashankar Das Swagatika Das Edgar A. Borrego Cristina D. Guerena Clare R. Hernandez Renato J. Aguilera Jonathan R. Dimmock 《Molecules (Basel, Switzerland)》2022,27(19)
Two series of novel unsymmetrical 3,5-bis(benzylidene)-4 piperidones 2a–f and 3a–e were designed as candidate antineoplastic agents. These compounds display potent cytotoxicity towards two colon cancers, as well as several oral squamous cell carcinomas. These compounds are less toxic to various non-malignant cells giving rise to large selectivity index (SI) figures. Many of the compounds are also cytotoxic towards CEM lymphoma and HL-60 leukemia cells. Representative compounds induced apoptotic cell death characterized by caspase-3 activation and subG1 accumulation in some OSCC cells, as well as the depolarization of the mitochondrial membrane potential in CEM cells. A further line of inquiry was directed to finding if the SI values are correlated with the atomic charges on the olefinic carbon atoms. The potential of these compounds as antineoplastic agents was enhanced by an ADME (absorption, distribution, metabolism, and excretion) evaluation of five lead molecules, which revealed no violations. 相似文献
79.
Enrique Navarrete- de Gálvez José Aguilera María Victoria de Gálvez Pablo Fonda-Pascual Enrique Herrera-Ceballos Alfonso Gago-Calderón 《Photochemistry and photobiology》2020,96(6):1267-1272
Photodynamic therapy is taking importance as a nonintrusive treatment for nail onychomycosis. Knowledge of true transmittance values across nails could lead to qualitative and quantitative improvements in light-based treatments. We have characterized the spectral transmittance of healthy and fungally infected human fingernails and toenails according to nail thickness, and we propose a surface transmittance model for the small-scale optimization of light-based treatments. Transmittance of fingernails and toenails was analyzed by means of spectroradiometric measurements under solar-simulated visible light radiation (400 nm to 750 nm). The nail thickness was measured by means of microscope measurement. Transmittance was highest at longer wavelengths and decreased gradually as the wavelengths became shorter but with a significant nail transmittance of around 20% in the blue region of the spectrum. In the case of nails affected by onychomycosis, transmittance fell to under 10% because of the thickness of the nails, with no changes in spectral characteristics of transmitted light. Nail thickness is the main variable controlling exponentially light transmission in the visible spectrum and not only red radiation is effective for nail onychomycosis PDT. Blue light, the spectral band more effective for PPIX absorption is also effectively transmitted. 相似文献
80.
C. Aguilera S. Ahmad J. Bartulín H. J. Müller 《Molecular Crystals and Liquid Crystals》2013,570(2):277-282
DSC and microscopic data are presented for a thermotropic twin mesogen series. Deviations from normal trends were observed. 相似文献