Puckering behavior in six new phosphoric triamides containing aliphatic six- and seven-membered ring groups and a database survey of analogous ring-containing structures

The influence of a N heteroatom on the ring conformations of six- and seven-membered aliphatic rings in six new C(O)NHP(O)-based phosphoric triamide structures (analysed by X-ray crystallography) is investigated. Additionally the influence of steric and crystal packing effects is also studied by the analysis of Hirshfeld surfaces. The results are compared to analogous structures with three- to seven- aliphatic membered rings deposited in the Cambridge Structural Database. In the newly determined structures, the six-membered rings only show the near-chair conformation with a maximum deviation of the θ puckering parameter of 4.4° from the ideal chair value of 0°/180°, while the seven-membered rings are found in different conformations such as near-chair, twist chair and twist sofa.     

"Competitive quenching": a mechanism by which perihydroxylated perylenequinone photosensitizers can prevent adverse phototoxic damage caused by verteporfin during photodynamic therapy

Incorporation of photodynamic therapy into clinical practice for induction of vascular photo-occlusion highlights the need to prevent adverse phototoxicity to sensitive juxtaposed tissues, particularly in the retina. We developed a system termed "competitive quenching" to prevent adverse phototoxic damage. It involves differential compartmentalization of a photoactivator to the intravascular compartment for photoexcitation and delivery of phototoxicity to targeted vessels. A different photodynamic agent is partitioned to the extravascular retinal space to quench reactive oxygen species generated by photosensitization, thereby protecting the adjacent retinal tissues from adverse phototoxicity. The absorption spectra of quenchers must span wavelengths that are shorter and excluded from the spectral range of photoexcitation light to prevent photoactivation of the quencher. Perihydroxylated perylenequinones were found to be suitable to function as "competitive quenchers" with the prototype hypericin identified as a potent quencher. Here we examined the mechanisms operative in competitive quenching and suggest that hypericin forms a complex with verteporfin, thereby quenching singlet oxygen formation. Furthermore, we show that hypericin, with six phenolic hydroxyls, protects retinal and endothelial hybridoma cells from phototoxicity more effectively than the dimethyl tetrahydroxy helianthrone structural analog with only four such phenolic hydroxyls. The findings suggest that hydroxyl numbers contribute to the efficacy of competitive quenching.     

Unpredicted electron injection in CdS/CdSe quantum dot sensitized ZrO2 solar cells

A quantum dot sensitized solar cell based on a porous ZrO(2) film, sensitized with CdSe quantum dots using CdS as an intermediate layer is presented. We observe electron injection from photo-excited quantum dots into the ZrO(2), which is unexpected due to the much higher conduction band edge (closer to the vacuum level) of bulk ZrO(2) compared to TiO(2).     

Quantification of water compartmentation in cell suspensions by diffusion-weighted and T(2)-weighted MRI

When studying water diffusion in biological systems, any specific signal attenuation curve may be reproduced by a broad range of mathematical functions. Our goals were to quantify the diffusion and T₂ relaxation properties of water in a simple biological system and to study the changes that occur in osmotically stressed cells.     

Output power and spectrum of optical parametric generator in the superfluorescent regime

Explicit expressions for the irradiance and signal spectrum of an optical parametric generator were derived. The calculation is in quantitative agreement with measurements of parametric generators with three different lengths of crystals operating in the superfluorescent regime. The measured spectrum was predicted for the entire measured range up to a gain-length product of 16, and the measured signal power was accurately derived up to a gain-length product of 10.     

Coulomb blockade as a probe for non-Abelian statistics in Read-Rezayi states

We consider a quantum dot in the regime of the quantum Hall effect, particularly in Laughlin states and non-Abelian Read-Rezayi states. We find the location of the Coulomb blockade peaks in the conductance as a function of the area of the dot and the magnetic field. When the magnetic field is fixed and the area of the dot is varied, the peaks are equally spaced for the Laughlin states. In contrast, non-Abelian statistics is reflected in modulations of the spacing which depend on the magnetic field.     

Bulk-edge coupling in the non-Abelian nu=5/2 quantum hall interferometer

Recent schemes for probing non-Abelian statistics in the quantum Hall effect are based on geometries where current-carrying quasiparticles flow along edges that encircle bulk quasiparticles, which are localized. Here we consider one such scheme, the Fabry-Perot interferometer, and analyze how its interference patterns are affected by a coupling that allows tunneling of neutral Majorana fermions between the bulk and edge. While at weak coupling this tunneling degrades the interference signal, we find that at strong coupling, the bulk quasiparticle becomes essentially absorbed by the edge and the intereference signal is fully restored. Furthermore, we find that the strength of the coupling can be tuned by the source-drain voltage.