Search for new phenomena in tt events with large missing transverse momentum in proton-proton collisions at sqrt[s] = 7 TeV with the ATLAS detector

A search for new phenomena in tt events with large missing transverse momentum in proton-proton collisions at a center-of-mass energy of 7 TeV is presented. The measurement is based on 1.04 fb(-1) of data collected with the ATLAS detector at the LHC. Contributions to this final state may arise from a number of standard model extensions. The results are interpreted in terms of a model where new top-quark partners are pair produced and each decay to an on-shell top (or antitop) quark and a long-lived undetected neutral particle. The data are found to be consistent with standard model expectations. A limit at 95% confidence level is set excluding a cross section times branching ratio of 1.1 pb for a top-partner mass of 420 GeV and a neutral particle mass less than 10 GeV. In a model of exotic fourth generation quarks, top-partner masses are excluded up to 420 GeV and neutral particle masses up to 140 GeV.     

On the Consistency between the Assumption of a Special System of Reference and Special Relativity

In a previous work, we have shown that the null result of the Michelson–Morley experiment in vacuum is deeply connected with the notion of time. The same is true for the postulate of constancy of the two-way speed of light in vacuum in all frames independently of the state of motion of the emitting body. The argumentation formerly given is very general and has to be true not only within Special Relativity and its “equivalence” of all inertial frames, but as well as in Lorentz-Poincaré scenario of a preferred reference frame. This paper is the second of a trilogy intending to revisit the foundations of Special Relativity, and addresses the question of the constancy of the one-way speed of light and of the differences and similarities between both scenarios. Although they manifestly differ in philosophy, it is debated why and how the assumption of a “special system of reference experimentally inaccessible” is indeed compatible with Einstein’s Special Relativity, as beautifully outlined and discussed by Bell [Speakable and Unspeakable in Quantum Mechanics (Cambridge University Press, Cambridge, 1988)]. This rather trivial statement is still astonishing nowadays to a big majority of scientists. The purpose of this work is to bring such assertion into perspective, widening the somewhat narrow view of Special Relativity often presented in textbooks and scientific papers.     

A novel type of bis-quinolizidine alkaloid from the sponge: Petrosia seriata

The structure of petrosin, the major alkaloid isolated from the sponge Petrosia seriata, has been determined by X-ray diffraction analysis. Petrosin is the first member of a new class of bis-quinolizidine alkaloids containing a C-16 macrocycle.     

Search for dilepton resonances in pp collisions at √s=7 TeV with the ATLAS detector

This Letter reports on a search for narrow high-mass resonances decaying into dilepton final states. The data were recorded by the ATLAS experiment in pp collisions at √s=7 TeV at the Large Hadron Collider and correspond to a total integrated luminosity of 1.08 (1.21) fb(-1) in the e(+)e(-) (μ(+)μ(-)) channel. No statistically significant excess above the standard model expectation is observed and upper limits are set at the 95% C.L. on the cross section times branching fraction of Z' resonances and Randall-Sundrum gravitons decaying into dileptons as a function of the resonance mass. A lower mass limit of 1.83 TeV on the sequential standard model Z' boson is set. A Randall-Sundrum graviton with coupling k/M(Pl)=0.1 is excluded at 95% C.L. for masses below 1.63 TeV.     

Chemoselective Synthesis of Mannich Adducts from 1,4-Naphthoquinones and Profile as Autophagic Inducers in Oral Squamous Cell Carcinoma

Oral squamous cell carcinoma (OSCC) is a worldwide public health problem, accounting for approximately 90% of all oral cancers, and is the eighth most common cancer in men. Cisplatin and carboplatin are the main chemotherapy drugs used in the clinic. However, in addition to their serious side effects, such as damage to the nervous system and kidneys, there is also drug resistance. Thus, the development of new drugs becomes of great importance. Naphthoquinones have been described with antitumor activity. Some of them are found in nature, but semi synthesis has been used as strategy to find new chemical entities for the treatment of cancer. In the present study, we promote a multiple component reaction (MCR) among lawsone, arylaldehydes, and benzylamine to produce sixteen chemoselectively derivated Mannich adducts of 1,4-naphthoquinones in good yield (up to 97%). The antitumor activities and molecular mechanisms of action of these compounds were investigated in OSCC models and the compound 6a induced cytotoxicity in three different tumor cell lines (OSCC4, OSCC9, and OSCC25) and was more selective (IS > 2) for tumor cells than the chemotropic drug carboplatin and the controls lapachol and shikonin, which are chemically similar compounds with cytotoxic effects. The 6a selectively and significantly reduced the amount of cell colony growth, was not hemolytic, and tolerable in mice with no serious side effects at a concentration of 100 mg/kg with a LD₅₀ of 150 mg/kg. The new compound is biologically stable with a profile similar to carboplatin. Morphologically, 6a does not induce cell retraction or membrane blebs, but it does induce intense vesicle formation and late emergence of membrane bubbles. Exploring the mechanism of cell death induction, compound 6a does not induce ROS formation, and cell viability was not affected by inhibitors of apoptosis (ZVAD) and necroptosis (necrostatin 1). Autophagy followed by a late apoptosis process appears to be the death-inducing pathway of 6a, as observed by increased viability by the autophagy inhibitor (3-MA) and by the appearance of autophagosomes, later triggering a process of late apoptosis with the presence of caspase 3/7 and DNA fragmentation. Molecular modeling suggests the ability of the compound to bind to topoisomerase I and II and with greater affinity to hPKM2 enzyme than controls, which could explain the mechanism of cell death by autophagy. Finally, the in-silico prediction of drug-relevant properties showed that compound 6a has a good pharmacokinetic profile when compared to carboplatin and doxorubicin. Among the sixteen naphthoquinones tested, compound 6a was the most effective and is highly selective and well tolerated in animals. The induction of cell death in OSCC through autophagy followed by late apoptosis possibly via inhibition of the PKM2 enzyme points to a promising potential of 6a as a new preclinical anticancer candidate.     

Theoretical characterization of the BN and BP coronenes by IR, Raman, and UV-VIS spectra

Boron-nitrogen coronene (BNC) and boron-phosphorous coronene (BPC), not yet synthesized molecules and of possible interest for material science, are composed of six condensed rings of borazine and boraphosphabenzene molecules, respectively. They are similar to the carbon coronene molecule (CC). Moreover, CC and BNC are isoelectronic and the BPC is formally isoelectronic with respect to other coronenes, if only the valence electrons are considered. In this work, the BNC and BPC were theoretically characterized using IR, Raman, and UV-VIS spectroscopies. The coronenes studied have D(6h) and D(3h) symmetries for carbon and boron compounds, respectively. The calculated vibrational and electronic spectra for the CC are in good agreement with the experimental data, indicating that the calculations for BNC and BPC will be useful to identify these compounds, when synthesized. The main vibrational modes of the CC, BNC, and BPC are correlated. However, the BPC vibrational frequencies are substantially lower than the CC and BNC ones. The electronic ground state studies showed that the BPC has intermediate characteristics between the CC and BNC.     

Synthesis of pure stereoisomers of benzo[b]thienyl dehydrophenylalanines by Suzuki cross-coupling. Preliminary studies of antimicrobial activity

Several benzo[b]thienyldehydrophenylalanines were synthesized from pure stereoisomers of the methyl ester of N-(tert-butoxycarbonyl)-β-bromodehydrophenylalanine as an extension of our previously reported method for the synthesis of dehydrotryptophan analogues to dehydrophenylalanine derivatives. The latter were obtained in high yields by N-deprotection and bromination of N,N-bis-(tert-butoxycarbonyl)-(Z)-dehydrophenylalanine using TFA and NBS. This was carried out in two steps or in a one pot procedure resulting in different E/Z ratios. These compounds were coupled under Suzuki cross-coupling conditions [Pd(PPh₃)₄, Na₂CO₃, DME/H₂O] with several boronic benzo[b]thienyl acids in good to high yields maintaining the stereochemistry of the starting materials. The best yields were obtained when the boronic acid was in position 7 of the benzo[b]thiophene and with the E isomer of the brominated dehydrophenylalanine. In some cases it was possible to increase the lower yields by changing the Pd source to PdCl₂(PPh₃)₂. A model dipeptide was prepared coupling a benzo[b]thienyldehydrophenylalanine with the methyl ester of alanine. Preliminary antimicrobial studies were performed with both isomers of one of the β, β-diaryldehydroalanines obtained. The results show that the compounds are selective and very active (very low MICs) against Gram positive bacteria (B. cereus and B. subtilis) the Z-isomer being more active. The compounds are also active against Candida albicans presenting similar MICs.