Compound A Increases Cell Infiltration in Target Organs of Acute Graft-versus-Host Disease (aGVHD) in a Mouse Model

Systemic steroids are used to treat acute graft-versus-host disease (aGVHD) caused by allogenic bone marrow transplantation (allo-BMT); however, their prolonged use results in complications. Hence, new agents for treating aGVHD are required. Recently, a new compound A (CpdA), with anti-inflammatory activity and reduced side effects compared to steroids, has been identified. Here, we aimed to determine whether CpdA can improve the outcome of aGVHD when administered after transplantation in a mouse model (C57BL/6 in B6D2F1). After conditioning with 9Gy total body irradiation, mice were infused with bone marrow (BM) cells and splenocytes from either syngeneic (B6D2F1) or allogeneic (C57BL/6) donors. The animals were subsequently treated (3 days/week) with 7.5 mg/kg CpdA from day +15 to day +28; the controls received 0.9% NaCl. Thereafter, the incidence and severity of aGVHD in aGVHD target organs were analyzed. Survival and clinical scores did not differ significantly; however, CpdA-treated animals showed high cell infiltration in the target organs. In bulk mixed lymphocyte reactions, CpdA treatment reduced the cell proliferation and expression of inflammatory cytokines and chemokines compared to controls, whereas levels of TNF, IL-23, chemokines, and chemokine receptors increased. CpdA significantly reduced proliferation in vitro but increased T cell infiltration in target organs.     

On Finite and Strong Convergence of a Proximal Method for Equilibrium Problems

We introduce the notions of conditioning and well-posedness for equilibrium problems. Using these concepts, we obtain finite and strong convergence results for the proximal method that improve, develop, and unify several theorems in optimization and nonlinear analysis.     

Well-behaved asymptotical convex-concave functions

Recently Auslender & Crouzeix introduced a well-behaved asymptotical notion for convex functions. The aim of this work is to extend this notion to the saddle case     

A partial complement method for approximating solutions of a primal dual fixed-point problem

We study the convergence of the Mann Iteration applied to the partial complement of a firmly nonexpansive operator with respect to a linear subspace of a Hilbert space. A new concept considered here. A regularized version is also proposed. Furthermore, to motivate this concept, some applications to robust regression procedures and location problems are proposed.     

Synthesis of purine-acridine hybrid molecules related to artificial endonucleases

In the course of a program devoted to the synthesis of artificial endonucleases, we have previously reported a series of hybrid molecules in which a purine is linked to an intercalating drug by a polyamino chain. These molecules recognize and cleave selectively abasic sites in DNA with very high efficiency. In order to get insight into the mechanism of recognition and cleavage, we have prepared a new series of molecules in which the purine is linked to an amino-acridine by an aliphatic chain containing amido or/and amino groups. The key intermediates are -halo-ω-amino polyaza which may be of general use as linkers in bioconjugate chemistry.     

The Synthesis of Natural Acetylenic Compounds from Stereum hirsutum

The regioselective synthesis of two new acetylenic compounds, sterehirsutinal ( 1 ) and sterehirsutinol ( 2 ), isolated recently from culture medium of the fungus Stereum hirsutum, is reported.     

Computational study of sulfur atom-transfer reactions from thiiranes to ER3 (E = As, P; R = CH3, Ph)

Computational estimates have been made for the P=S and As=S bond strengths in triphenylphosphine sulfide and triphenylarsine sulfide, on the basis of G3 calculations for the methyl analogues and isodesmic-exchange reactions. Also, with the performance of the G3 method level for related compounds taken into consideration, the best estimates are 82 and 68 kcal/mol, respectively. While the value for triphenylarsine sulfide is within 2 kcal/mol of the single experimental estimate, that for triphenylphosphine sulfide is lower by 6 kcal/mol. (Capps, K. B.; Wixmerten, B.; Bauer, A.; Hoff, C. D. Inorg. Chem. 1998, 37, 2861-2864.) Despite virtually identical electronegativities of P and As, it is found that there is greater charge separation in the P=S bond. It is found that S atom transfer from thiiranes to arsines is exothermic.     

Chloro(η6‐p‐cymene)(2‐methyl‐5‐oxo‐7‐phenyl‐5,6‐di­hydro‐2H‐1,2,4‐triaz­epine‐3‐thiol­ato‐κ2N4,S)­ruthenium(II)

The novel title ruthenium(II) complex, [RuCl(C₁₀H₁₄)(C₁₀H₁₀N₃OS)], was synthesized from the reaction of 1,2,4‐triazepine, a new class of bidentate ligands, with [Ru(p‐cymene)Cl₂]₂. The 1,2,4‐triazepine ligand is coordinated to the metal centre through the N‐4 and S atoms, forming a four‐membered chelate ring. This is the first structural example of a transition metal complex containing a 1,2,4‐triazepine ligand.     

A posteriori error estimator for finite volume methods

In this paper, first we discuss a technique to compare finite volume method and some well-known finite element methods, namely the dual mixed methods and nonconforming primal methods, for elliptic equations. These both equivalences are exploited to give us a posteriori error estimator for finite volume methods. This estimator is explicitly given, easy to compute and asymptotically exact without any regularity of the solution in unstructured grids.