Synthèse Et Cyclisation De Carboxylsulfamides Dérivés D'amines Et D'α-Hydroxyesters. Éavaluation De L'Activité Bactéeriostatique

Abstract

Les carboxylsulfamides sont obtenus à partir de l'isocyanate de chlorosulfonyle, d'amines primaires et d'α-hydroxyesters. Après réduction alcaline, ces carboxylsulfamides sont cyclisés dans les conditions de la réaction de Mitsunobu pour conduire aux N-sulfamoyloxazolidinones chides avec des rendements élevés.

The synthesis of carboxylsulfamides was carried out starting from chlorosulfonyl isocyanate, primary amines and α-hydroxyesters. After reduction, the carboxylsulfamides were cyclised under Mitsunobu conditions giving N-sulfamoyloxazolidinones in good yields.     

A conductometric immunosensor based on functionalized magnetite nanoparticles for E. coli detection

We report a new approach for immunoassays based on magnetite nanoparticles for Escherichia coli (E. coli) detection using conductometric measurements. Biotinylated antibodies, anti-E. coli, were immobilized on streptavidin modified magnetite nanoparticles by biotin–streptavidin interaction. A layer of functionalized nanoparticles were directly immobilized on the conductometric electrode using glutaraldehyde cross-linking.The specific test with E. coli cells and the non specific test using Staphylococcus epidermidis (S. epidermidis) were investigated by conductometric measurements. Results show a good response as a function of antigen additions. The detection of 1 CFU/ml of E. coli induces a conductivity variation of 35 μS. The negative test shows good selectivity using the conductometric immunosensor. Conductometric measurements allow to detect 500 CFU/l.     

Impulsive stochastic functional differential inclusions driven by a fractional Brownian motion with infinite delay

In this paper, we prove the existence of mild solutions for a first‐order impulsive semilinear stochastic functional differential inclusions driven by a fractional Brownian motion with infinite delay. We consider the cases in which the right hand side is convex or nonconvex valued. The results are obtained by using two different fixed point theorems for multivalued mappings. Copyright © 2015 John Wiley & Sons, Ltd.     

Preparation of biotinylated glyconanoparticles via a photochemical process and study of their bioconjugation to streptavidin

We report here the preparation of novel biotinylated glyconanoparticles from well-defined biotinylated glycopolymers and poly(N-isopropylacrylamide) (PNIPAAm) synthesized via the reversible addition fragmentation chain transfer (RAFT) polymerization process. The in situ reduction of the biotinylated glycopolymers, PNIPAAm, poly(ethylene glycol), and HAuCl4 via a photochemical process resulted in the formation of biotinylated gold nanoparticles. The multifunctional biotinylated glyconanoparticles were then evaluated for their bioconjugation toward streptavidin using UV-vis spectroscopy and surface plasmon resonance (SPR). The biotinylated nanoparticles underwent aggregation in the presence of streptavidin as revealed by spectrophotometry, which indicates the accessibility of the biotin for conjugation. These results were further confirmed by surface plasmon resonance even in the case of surface-immobilized streptavidin.     

Pharmacological Evaluation of Novel Organoiron Dendrimers as Antimicrobial and Anti‐Inflammatory Agents

The synthesis of a novel and attractive class of nonsteroidal anti‐inflammatory and antimicrobial organoiron dendrimers attached to the well‐known drug ibuprofen is achieved. The structures of these dendrimers are established by spectroscopic and analytical techniques. The antimicrobial activity of these dendrimers is investigated and tested against five human pathogenic Gram‐positive and Gram‐negative bacteria, and minimum inhibitory concentrations are reported. Some of these synthesized dendrimers exhibit higher inhibitory activity against methicillin‐resistant Staphylococcus aureus, vancomycin‐resistant Enterococcus faecium, and Staphylococcus warneri compare to the reference drugs. As well, the in vitro and in vivo anti‐inflammatory activities of these dendrimers are evaluated. The results of in vivo anti‐inflammatory activity and histopathology of inflamed paws show that all dendrimers display considerable anti‐inflammatory activity; however, second‐generation dendrimer ( G2‐D6 ) shows the best anti‐inflammatory activity, which is more potent than the commercial drug ibuprofen at the same tested dose. Results of the toxicity study reveal that G2‐D6  is the safest drug on biological tissues.     

One-pot green synthesis,study of fluorescence properties,and biological activity of pyrano[3,2-c]chromenes derivatives via mesoporous materials MgO/SBA-15

This current work describes the preparation of MgO-SBA-15 catalysts by ultrasonic method, and it is characterized by the different analysis techniques of XRD, BET, SEM, and IRTF. In order to find out an application for this mesoporous material, MgO/SBA-15 was used as a heterogeneous catalyst in the one-pot synthesis of pyrano[3,2-c]chromenes derivatives isolated at room temperature reaction according to green chemistry criteria. To enhance these derivatives, a spectroscopic study of molecular fluorescence properties was carried out as well as an identification analysis by nuclear magnetic resonance and FTIR was used. Furthermore, biological activity experiment is also carried out, from where the obtained test results were satisfactory for AC09 , AC05 , and AC10 compounds and they are checked after computation by molecular modeling.     

Topological structure of solution sets for impulsive differential inclusions in Fréchet spaces

In this paper, we consider the existence of solutions as well as the topological and geometric structure of solution sets for first-order impulsive differential inclusions in some Fréchet spaces. Both the initial and terminal problems are considered. Using ingredients from topology and homology, the topological structures of solution sets (closedness and compactness) as well as some geometric properties (contractibility, acyclicity, AR and R_δ) are investigated. Some of our existence results are obtained via the method of taking the inverse system limit on noncompact intervals.     

A Filippov’s Theorem, Some Existence Results and the Compactness of Solution Sets of Impulsive Fractional Order Differential Inclusions

In this paper, we first present an impulsive version of Filippov's Theorem for fractional differential inclusions of the form, $$\begin{array}{lll} \quad \qquad D^{\alpha}_{*}y(t) & \in & F(t, y(t)), \quad\; {\rm a.e.}\ t\, \in \, J{\backslash} \{t_{1}, \ldots, t_{m}\}, \ \alpha\, \in \, (0,1], \\ y(t^{+}_{k}) - y(t^{-}_{k}) & = & I_{k}(y(t^{-}_{k})), \quad k = 1, \ldots, m, \\ \qquad \qquad y(0) & = & a,\end{array}$$ where J = [0, b], ${D^{\alpha}_{*}}$ denotes the Caputo fractional derivative and F is a set-valued map. The functions I _k characterize the jump of the solutions at impulse points t _k ( ${k = 1, \ldots , m}$ ). In addition, several existence results are established, under both convexity and nonconvexity conditions on the multivalued right-hand side. The proofs rely on a nonlinear alternative of Leray-Schauder type and on Covitz and Nadler??s fixed point theorem for multivalued contractions. The compactness of solution sets is also investigated.     

Random solutions to a system of fractional differential equations via the Hadamard fractional derivative

In this work, we use a new random fixed point theorem in vector metric spaces due to Sinacer et al. [M.L. Sinacer et al., Random Oper. Stoch. Equ. 24, 93 (2016)] to prove the existence of solutions and the compactness of solution sets of a random system of fractional differential equations via the Hadamard-type derivative. The existence, modification and stochastically continuity of an M²-solution are also proved.