A note on a single-vendor and multiple-buyers production-inventory policy for a deteriorating item

In this note we examine the total cost function of a single-vendor multiple-buyers production-inventory policy for a deteriorating item by Yang and Wee [P.C. Yang and H.M. Wee, A single-vendor multiple-buyers production-inventory policy for a deteriorating item, European Journal of Operational Research 143 (2002) 570–581]. Two possible flaws in the cost function of Wee and Yang’s model are pointed out. A proposal to eradicate the flaws is given.     

An optimal software debugging model

This paper deals with the question of optimal debugging times for large-scale computer programs, given certain assumptions concerning the distribution of error within the program, the cost that is incurred whenever a fault occurs, and the cost of debugging. Modeling takes place within the framework of independent Poisson processes describing faults caused by errors. The optimization aim is to minimize the long-run total expected discounted cost. Some general results concerning the optimal polity are presented.This research has been supported by NATO Grant No. RG.86/0024, by the Alexander von Humboldt Foundation, and by the University of Passau, Germany.     

The influence of sensitivity for road traffic noise on residential location: does it trigger a process of spatial selection?

People move to another house for different reasons. It is sometimes presumed that a process of self-selection might take place on the basis of noise sensitivity, i.e., sensitive people would either leave high noise areas or not move into these areas in the first place. Thus, a "survivor population" would remain in the high noise areas. This research aims to investigate whether such a process can be observed in the Netherlands. The study does not show evidence of a process of self-selection based on noise sensitivity. Nevertheless, the results suggest that noise-sensitive people are less satisfied with their living environment and are more willing to move than those who are not noise sensitive. Due to the limited sample size, external validity is limited.     

Induction of targeted necrosis with HER2-targeted platinum(iv) anticancer prodrugs

It is well-recognized that the failure of many chemotherapeutics arises due to an inability to induce apoptosis. Most cancers acquire a myriad of pro-survival adaptations, and the vast heterogeneity and accumulation of multiple often unrelated anti-apoptotic signaling pathways have been a major stumbling block towards the development of conventional chemotherapeutics, which can overcome drug resistance. We have developed highly potent and selective HER2-targeted Pt(iv) prodrugs bearing anti-HER2/neu peptides that induce targeted necrosis as a novel strategy to circumvent apoptosis-resistance. These Pt(iv)–peptide conjugates exhibit a unique biphasic mode of cytotoxicity comprising rapid killing of cancer cells via necrosis in the first phase followed by an extended and gradual phase of delayed cell death. We demonstrate that these Pt(iv)–peptide prodrugs are more potent than their Pt(ii) congeners in direct cell-killing and exhibit comparable long-term inhibition of proliferative capacity and with greater selectivity against HER2-positive cancer cells.     

Proteome profile of salt gland‐rich epidermis extracted from a salt‐tolerant tree species

Preparation of proteins from salt‐gland‐rich tissues of mangrove plant is necessary for a systematic study of proteins involved in the plant's unique desalination mechanism. Extraction of high‐quality proteins from the leaves of mangrove tree species, however, is difficult due to the presence of high levels of endogenous phenolic compounds. In our study, preparation of proteins from only a part of the leaf tissues (i.e. salt gland‐rich epidermal layers) was required, rendering extraction even more challenging. By comparing several extraction methods, we developed a reliable procedure for obtaining proteins from salt gland‐rich tissues of the mangrove species Avicennia officinalis. Protein extraction was markedly improved using a phenol‐based extraction method. Greater resolution 1D protein gel profiles could be obtained. More promising proteome profiles could be obtained through 1D‐LC‐MS/MS. The number of proteins detected was twice as much as compared to TUTS extraction method. Focusing on proteins that were solely present in each extraction method, phenol‐based extracts contained nearly ten times more proteins than those in the extracts without using phenol. The approach could thus be applied for downstream high‐throughput proteomic analyses involving LC‐MS/MS or equivalent. The proteomics data presented herein are available via ProteomeXchange with identifier PXD001691.     

Molecular trapping on two-dimensional binary supramolecular networks

Molecular preferential adsorption on molecular patterned surfaces via specific intermolecular interactions provides an efficient route to construct ordered organic nanostructures for future nanodevices. Here, we demonstrate the preferential trapping of second-layer molecules atop two-dimensional binary supramolecular networks, F(16)CuPc on DIP:F(16)CuPc and 6P:F(16)CuPc systems, respectively, through intermolecular π-π interactions. The formation of the second-layer supramolecular nanostructures, individual molecular dots or linear molecular chains, can be controlled by the underlying molecular networks.     

Charge transfer dynamics of 3,4,9,10-perylene-tetracarboxylic-dianhydride molecules on Au(111) probed by resonant photoemission spectroscopy

Charge transfer dynamics across the lying-down 3,4,9,10-perylene-tetracarboxylic-dianhydride (PTCDA) organic semiconductor molecules on Au(111) interface has been investigated using the core-hole clock implementation of resonant photoemission spectroscopy. It is found that the charge transfer time scale at the PTCDA∕Au(111) interface is much larger than the C 1s core-hole lifetime of 6 fs, indicating weak electronic coupling between PTCDA and the gold substrate due to the absence of chemical reaction and∕or bonding.     

Optimal deteriorating items production inventory models with random machine breakdown and stochastic repair time

This study develops deteriorating items production inventory models with random machine breakdown and stochastic repair time. The model assumes the machine repair time is independent of the machine breakdown rate. The classical optimization technique is used to derive an optimal solution. A numerical example and sensitivity analysis are shown to illustrate the models. The stochastic repair models with uniformly distributed repair time tends to have a larger optimal total cost than the fixed repair time model, however the production up time is less than the fixed repair time model. Production and demand rate are the most sensitive parameters for the optimal production up time, and demand rate is the most sensitive parameter to the optimal total cost for the stochastic model with exponential distribution repair time.     

Solving the vendor–buyer integrated inventory system with arithmetic–geometric inequality

In the past, economic order quantity (EOQ) and economic production quantity (EPQ) were treated independently from the viewpoints of the buyer or the vendor. In most cases, the optimal solution for one player was non-optimal to the other player. In today’s competitive markets, close cooperation between the vendor and the buyer is necessary to reduce the joint inventory cost and the response time of the vendor–buyer system. The successful experiences of National Semiconductor, Wal-Mart, and Procter and Gamble have demonstrated that integrating the supply chain has significantly influenced the company’s performance and market share (Simchi-Levi et al. (2000) [1]). Recently, Yang et al. (2007) [2] presented an inventory model to determine the economic lot size for both the vendor and buyer, and the number of deliveries in an integrated two stage supply chain. In this paper, we present an alternative approach to determine the global optimal inventory policy for the vendor–buyer integrated system using arithmetic–geometric inequality.     

Synthesis of fullerene@gold core-shell nanostructures

A "direct encapsulation" method was developed for the synthesis of highly stable water-soluble fullerene@gold core-shell nanostructures, with gold nanoshells showing either closed or porous morphology. This gold nano-shell coating formed a "nano-oven", capable of decomposing encapsulated fullerene molecules rapidly when irradiated by laser. We envisaged this being a useful tool for chemical reactions as well as a novel scaffold for nano-material synthesis.