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31.
A new series of 6,8-dibromo-2-(4-chlorophenyl)quinazolin-4(3H)-one derivatives VI–XIII were synthesized. Their chemical structures were confirmed by spectral and elemental analysis. The cytotoxic effect of the newly synthesized compounds was tested in vitro against human breast cancer cell line (MCF-7). Most of the tested compounds have shown promising cytotoxic activity. Compounds X and XIIIb exerted a powerful cytotoxic effect against MCF-7 with a very low IC50 (0.0015 and 0.0047 µmol/ml), while compounds VI, VII, VIII, XIIb, XI, XIIIc and IX exerted a moderate cytotoxic effect (IC50 0.01523, 0.0213, 0.031, 0.0478, 0.049, 0.068 and 0.079 µmol/ml respectively), compared to doxorubicin (0.0025 µmol/ml). Exploring their apoptotic effect; interestingly,all compounds activated apoptotic cascade in MCF-7. Compounds VI, XIIIb, XIIb, XI, XIIa, VII, V and VIII showed potent effect even much more than doxorubicin by 12.87–5.91 folds, while compounds XIIIc, IX, XIIIa, XIIc and X showed moderate increase in CASP3 activity by 4.96–3.22 folds relative to untreated cells more or less similar to doxorubicin (5.57 folds). 相似文献
32.
Obliquely propagating altra-low-frequency dust-electromagnetic waves in a self-gravitating, warm, magnetized, two fluid dusty
plasma system have been investigated. Two special cases, namely, dust-Alfvén mode propagating parallel to the external magnetic
field and dustmagnetosonic mode propagating perpendicular to the external magnetic field have also been considered. It has
been shown that effects of self-gravitational field, dust fluid temperature, and obliqueness significantly modify the dispersion
properties of these ultra-low-frequency dust-electromagnetic modes. It is also found that in parallel propagating dust-Alfvén
mode these effects play no role, but in obliquely propagating dust-Alfvén mode or perpendicular propagating dust-magnetosonic
mode the effect of self-gravitational field plays destabilizing role whereas the effect of dust/ion fluid temperature plays
stabilizing role. 相似文献
33.
V. V. Perevozchikov A. A. Yukhimchuk Yu. I. Vinogradov M. D. Vikharev N. S. Ganchuk A. N. Golubkov S. K. Grishechkin A. M. Demin D. L. Demin A. A. Kononenko V. N. Lobanov I. L. Malkov S. A. Yukhimchuk V. G. Zinov 《Hyperfine Interactions》2001,138(1-4):417-420
The design of deuterium high-pressure target of 76 cm3 volume developed to study muon catalyzed fusion in diffusion-pure deuterium over an 80–800 K temperature range at up to 150
MPa pressure is presented.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献
34.
B. S. Neganov V. N. Trofimov A. A. Yukhimchuk L. N. Bogdanova 《Physics of Atomic Nuclei》2001,64(2):261-265
Some technical and technological aspects of development, design, and safe operation of an artificial tritium source with an antineutrino activity of 40 MCi for experiments to measure the neutrino magnetic momentum are considered. 相似文献
35.
It is shown how one can transform scalar first-order ordinarydifferential equations which admit non-local symmetries of theexponential type to integrable equations admitting canonicalexponential non-local symmetries. As examples we invoke theAbel equation of the second kind, the Riccati equation and naturalgeneralizations of these. Moreover, our method describes howa double reduction of order for a second-order ordinary differentialequation which admits a two-dimensional Lie algebra of generatorsof point symmetries can be affected if the second-order equationis first reduced in order once by a symmetry which does notspan an ideal of the two-dimensional Lie algebra. 相似文献
36.
37.
E. A. Denisov T. N. Kompaniets A. A. Yukhimchuk I. E. Boitsov I. L. Malkov 《Technical Physics》2013,58(6):779-786
A brief review of data for the influence of helium on the hydrogen sorption and mechanical properties of nickel and 12Kh18N10T steel is presented. When in the metallic matrix, helium considerably deteriorates the ductility of these metals. It is shown that 3He present in 12Kh18N10T steel generates high-energy hydrogen traps. 相似文献
38.
A. S. Fomichev L. V. Grigorenko M. S. Golovkov G. M. Ter-Akopian Yu. Ts. Oganessian V. A. Gorshkov S. A. Krupko A. M. Rodin S. I. Sidorchuk R. S. Slepnev S. V. Stepantsov R. Wolski V. Chudoba A. A. Korsheninnikov E. A. Kuzmin E. Yu. Nikolskii B. G. Novatskii D. N. Stepanov P. Roussel-Chomaz W. Mittig D. Pang A. Ninane F. Hanappe L. Stuttge A. A. Yukhimchuk V. V. Perevozchikov Yu. I. Vinogradov S. K. Grishechkin S. V. Zlatoustovskiy 《The European Physical Journal A - Hadrons and Nuclei》2009,42(3):465-469
Low-energy spectra of the 8, 10He nuclei were investigated in the (t, p) -type reactions at small centre-of-mass angles using ~ 25 AMeV beams of 6He and 8He nuclei. The 0+ ground state (g.s.) of 8He and excited states, 2+ at 3.6-3.9MeV and (1+) at 5.3-5.5MeV, were populated with cross-sections of 200, 100-250, and 90-125μb/sr, respectively. To account for a near-threshold anomaly observed in the 8He spectrum the population of a 1- continuum (soft dipole excitation) was considered. The lowest-energy group of events in the 10He spectrum was observed at ~ 3 MeV with a cross-section of ~ 140 μb/sr. This result is consistent with the previously reported observation of 10He providing a new g.s. position for 10He at about 3MeV. 相似文献
39.
Piezoelectricity is usually expressed as an interaction between mechanical and electrical variables. The physics involved is hence governed by a coupling between Maxwell's equations of electromagnetism and the equations of elasticity. Such a coupling takes us through the piezoelectric constitutive relations. In this work, the second order anisotropic constitutive equations are treated, and in particular, the number of independent material constants is computed for all the 32 crystallographic classes.Paper presented, in reduced version, at the 12th Italian National Congress of Theoretical and Applied Mechanics (AIMETA '95), October 1995, Naples, Italy. 相似文献
40.
The transition process from steady convection to chaos is experimentally studied in thermocapillary convections of floating half zone. The onset of temperature oscillations in the liquid bridge of floating half zone and further transitions of the temporal convective behaviour are detected by measuring the temperature in the liquid bridge. The fast Fourier transform reveals the frequency and amplitude characteristics of the flow transition. The experimental results indicate the existence of a sequence of period-doubling bifurcations that culminate in chaos. The measured Feigenbaum numbers are δ2 =4.69 and δ4 = 4.6, which are comparable with the theoretical asymptotic value δ=4.669. 相似文献