大环多胺配体BDBPH的设计合成及其晶体结构

用Pb(SN)₂作模板,2,6-二甲酰基对甲苯酚与二亚乙基三胺通过[2+2]缩合反应,经NaBH₄还原、脱Pb²⁺、酸化等操作,得晶体BDBPH·6HBr·4H₂O.晶体属单斜晶系,P2_1/c空间群,晶体学参数:a=1.4441(5)nm,b=1.1482(4)nm,c=1.2090(6)nm,α=90°,β=96.92°,γ=90°,V=1.9900nm³大环分子采取椅式构型,6个Br-和4个H₂O分子对称分布于大环两侧.该大环配体结构新颖,可用于多种金属配合物的研究,对进一步了解金属酶活性中心的结构及其催化作用机理具有重要价值.     

β—（酚酯基）乙基锗倍半氧化物的合成及对体外培养细胞的作用

β-羧基乙基锗倍半氧化物(即Ge-132)是一种无毒和具较强抗癌活性的有机锗化合物。为了进一步提高其抗癌活性。已对Ge-132进行了化学结构修饰。本文介绍8种未见报导的Ge-132衍生物,β-酚酯基乙基锗倍半氧化物的合成和体外培养细胞实验结果。     

含非紧值映射广义拟-似变分包含组解的存在性

引进一类新的具有非紧值映射的广义拟-似变分包含组.使用η-近似映射技巧,证明一个新的N-步迭代算法的收敛性和解的存在性.结果改进和推广了近期一些熟知的结果.     

β-羧乙基(或α-甲基乙基)锗三氯化物晶体和分子结构及其质谱分析

有机锗化合物的抗癌等广泛生物活性已引起人们对其研究的兴趣。β-羰乙基锗倍半氧化物(Ge-132)的生物活性已有广泛研究,对其衍生物合成及性质研究亦受到重视。作为合成这类衍生物的中间体,β-羧烃基锗三氯化物的结构和性质报道较少。我们制备了两种β-羧烷基锗三氯化物晶体,测定了其晶体和分子结构,研究了质谱裂解机理,讨论了结构和性质问的关系。     

超高效液相色谱-串联质谱结合内标法快速检测毛发中15种毒品及代谢物

建立了毛发中15种毒品及其代谢物的超高效液相色谱-串联质谱(UPLC-MS/MS)快速确证与内标定量分析方法.向洗净的毛发样品中加入甲醇研磨提取,研磨液经过滤后,以5 mmol/L NH4 Ac-0.1％甲酸水溶液及甲醇作为流动相,经Phenomenex Kinetex Biphenyl色谱柱(100 mm×3.0 m...     

两个渐近非扩张映射公共不动点的迭代程序

在一致凸Banach空间中,研究了迭代序列逼近收敛于两个渐近非扩张映射的公共不动点。所得结果推广了已有的一些结果。     

自反Banach空间中一类广义集值强

在自反Banach空间中引进并研究一类具有集值映射的广义强非线性变分不等式问题,并且证明了这类变分不等式解的存在性定理.结果修正、改进和推广了文献Cho Y.J等人的主要结果.     

关于广义集值混合变分不等式解的存在性及算法

在Hilbert空间中研究一类新的广义集值混合变分不等式，利用算子的豫解技巧在广义集值混合变分不等式与不动点问题之间建立等价关系，并给出了此类变分不等式解的存在性和算法的收敛性。     

Theoretical Study on the Reaction of Thymine with Iodomehane in the Water Phase

The reaction mechanisms of carcinogenic methylating agent iodomethane (MeI) with keto and enol tautomers of thymine (K- and E-thymine) were studied by using the B3LYP/6-311+G (d, p) method in water phase. The solvent effects were examined using the polarizable continuum model (PCM). Specifically, PCM single-point calculations at the same level of theory were performed in acetone and CCl4 that represent a range in nonpolarity. The calculated results show that the reaction of K-thymine with MeI is a two-step mechanism, whereas that of E-thymine is a one-step mechanism. Our calculations reveal that K-thymine is appreciably more stable than the enol form in the water phase or in the two solvents. The K- and E-form reaction barriers are 135.6 and 222.1 kJ/mol, respectively in water phase. These findings indicate that the reactions mentioned above could not occur efficiently in biological media in the absence of catalyst. Our conclusions are in agreement with the previous studies on the reactions of guanine with methyl chloride and methyl bromide.     

From Rosochatius System to KdV Equation

The Rosochatius system on the sphere, an integrable mechanical system discovered in the nineteenth century, is investigated in a suitably chosen framework with the sphere as an invariant set, to avoid the complicated constraint presentations. Higher order Rosochatius flows are defined and straightened out in the Jacobi variety of the associated hyperelliptic curve. A relation is found between these flows and the KdV equation, whose finite genus solution is calculated in the context of the Rosoehatius hierarchy.