Dielectric Properties of GaN in THz Frequencies

The complex refractive indices and the dielectric function of GaN for frequencies ranging from 0.25 to 1.22THz are obtained using THz time-domain spectroscopy. The real part of the dielectric function first decreases from 0.25 to 0.42THz and then oscillates from 0.42 to 1.22THz, whereas the imaginary part of the dielectric function is oscillating within the whole range of frequency. The simple Drude model is extended to take into account the effect of defects on the dielectric function. The extended model is in agreement with the experimental data.     

Growth of β-Ga_2O_3 Films on Sapphire by Hydride Vapor Phase Epitaxy

Two-inch Ga_2O_3 films with(ˉ201)-orientation are grown on c-sapphire at 850–1050°C by hydride vapor phase epitaxy. High-resolution x-ray diffraction shows that pure β-Ga_2O_3 with a smooth surface has a higher crystal quality, and the Raman spectra reveal a very small residual strain in β-Ga_2O_3 grown by hydride vapor phase epitaxy compared with bulk single crystal. The optical transmittance is higher than 80% in the visible and near-UV regions, and the optical bandgap energy is calculated to be 4.9 e V.     

Ac36deoGlcNAz could selectively label O-GlcNAc modified proteins with minimal S-glyco-modification

A novel metabolic chemical reporter of Ac36deo Glc NAz was developed and confirmed as an effective probe for O-Glc NAc modification. Ac36deo Glc NAz labeling predominantly occurs in intracellular OGlc NAcylated proteins rather than cell-surface glycoproteins. Of note, it could reduce the artificial S-glycomodification compared to Ac4Gal NAz and Ac4Glc NAz. This new reporter allows to be widely used in the field of proteomic identification of O-Glc NAcylation.     

Tumor-Penetrating and Mitochondria-Targeted Drug Delivery Overcomes Doxorubicin Resistance in Lung Cancer

As one of the major challenges in tumor chemotherapy, multidrug resistance typically correlates with the poor drug penetration within tumor tissues and drug efflux by the ATP-driven efflux pumps in tumor cells. Herein, we design a kind of near-infrared(NIR) light-and acidity-activated micellar i PUTDN nanoparticle for mitochondria-targeting doxorubicin(DOX) delivery to combat DOX resistance in small-cell lung cancer. While the PEGylated i PUTDN nanoparticles can keep stealth in blood circulation...