Synthesis and Crystal Structure of a Mixed Cu - Cd Bim etallic Com plex ｛〔 Cu Cd(pba)( H_2 O)_3〕·2 H_2 O｝ _n

１　ＩＮＴＲＯＤＵＣＴＩＯＮＨｅｔｅｒｏｍｅｔａｌｐｏｌｙｎｕｃｌｅａｒｃｏｍｐｌｅｘｅｓｈａｖｅｂｅｅｎｔｈｅｓｕｂｊｅｃｔｏｆｍａｎｙｒｅｃｅｎｔｓｔｕｄｉｅｓｔｏｅｌｕｃｉｄａｔｅｔｈｅｍｅｃｈａｎｉｓｍｏｆｓｐｉｎｃｏｕｐｌｉｎｇｂｅｔｗｅｅｎｔｈｅｍｅｔａｌｉｏｎｓ〔１,２〕,ｍｉｍｉｃｋｉｎｇｔｈｅａｃｔｉｖｅｓｉｔｅｏｆｓｏｍｅｍｅｔａｌｅｎｚｙｍｅｓｃｏｎｔａｉｎｉｎｇｄｉｓｓｉｍｉｌａｒｍｅｔａｌｉｏｎｓ,ｓｕｃｈａｓｃｙｔｏｃｈｒｏｍｅｏｘｉｄａｓｅａｎｄｓｕｐｅｒｏｘｉ…     

Nanjiols D and E, Two New Uncommon Steroids from the Chinese Soft Coral Nephthea bayeri

Marine organisms have been found to be a storehouse of steroids, particularly in term ofunique side-chain structures and unusual functionalization. Marine steroids are oftenfound in highly oxygenated forms and possessing various biological activities1.Previously, we reported the isolation and structural elucidation of three new marinesteroids, nanjiols A-C, which showed cytotoxicity against HL-60 and BEL 7402 celllines, from a soft coral Nephthea bayeri in East China Sea2. In continuation …     

Polystyrene-supported Benzyl Selenide: An Efficient Reagent for Highly Stereocontrolled Synthesis of Substituted Olefins

Solid-phase methodology has been rapidly and extensively applied to the preparation of small organic molecules recently1. It might be argued that selenoxide syn-elimination provided the principal impetus for the development of organoselenium chemistry. In addition, the required selenoxides are readily available from the oxidation of the corresponding selenides, which in turn can be prepared by the reaction of selenium-stabilized carbanions with various electrophilic substrates2. However, or…     

单分子结的构筑及分子电导性质的测试

分子电子学已成为21世纪研究的热点. 通过将具有特定功能的分子连接在纳米尺度金属电极之间从而构筑包括分子导线、开关、整流器在内的各种分子尺度电子器件, 这引起了科学家们广泛的研究兴趣. 在分子电子学研究中, 构筑金属/分子/金属(MMM)分子结是研究分子器件中电子传输性质的关键. 尽管已经取得了很大的进展, 目前在纳米尺度下构筑稳定可靠的MMM分子结并测试单个分子的电学性质仍然面临很多挑战. 本文着重对单分子电学性质的测试技术和相关理论研究的最新进展以及存在的挑战做了概述.     

反应性模板法合成硫化银中空球-银纳米粒子异质结构

以Cu₂S中空球为反应性模板, 通过在水溶液中与银离子的阳离子交换和氧化还原反应制备了大小均匀的Ag₂S中空球-Ag纳米粒子异质结构, 即Ag₂S-Ag异质中空球. 该异质结构中每个Ag₂S中空球的直径约为600 nm, 壁厚约20–30 nm, 其表面均附着一个Ag纳米粒子. 采用扫描电子显微镜(SEM)、透射电子显微镜(TEM)、X射线衍射(XRD)和能量色散X射线谱(EDS)对所得Ag₂S-Ag异质中空球的结构和组成进行了表征. 若以CuS中空球为反应性模板, 在相似转化条件下则主要得到不含Ag粒子的Ag₂S中空球. 该结果表明, Cu₂S中的Cu(I)的还原性在Ag₂S-Ag异质中空球的形成中发挥了重要作用. 通过对所制备的Ag₂S-Ag异质中空球进行二次生长, 还可以得到Ag₂S中空球的半球表面均被Ag膜所包覆的Ag₂S-Ag异质中空球.     

The Synthesis of N-Morphine Hapten and Production of Monoclonal Antibody

The drug overdose and addiction is a serious international problem. Therefore developing a rapid, accurate, convenient and cheap method for detecting morphine in urea is useful and necessary, especially for investigation of epidemiology, identification of medical jurisprudence and determination of drug addict etc. There are many compounds that are similar to morphine in chemical structure and tend to have cross-reaction with the anti-morphine antibody. In order to reduce the cross reaction a…     

One-Pot Synthesis of N-Boc-2, 5-bis(trimethylsilyl)pyrrolidine

Since Daly reported the structure of epibatidine and its potent analgesic activity in 19921, study on the synthesis of epibatidine and its derivatives and relationships between the structure and activity of epibatidine has received much attention2. During the course of our research for the synthesis of epibatidine derivatives, N-boc-2, 5-bis(trimethylsilyl)pyrrolidine 4 was used as the key intermediate to construct the skeleton of epibatidine via the 1, 3-dipolar cycloaddition (Scheme 1). Ac…     

Ni-B/TiO_2 Amorphous Catalyst Used in Heavy Arenes of Petrochemicals Hydrogenation

The various distillation of petroleum contains arenes. For environmental protection, the hydrogenation of arenes becomes important. The amorphous alloy is a new class of material with special catalytic properties for reduction arenes1-4. In this paper, we prepared the Ni-B/TiO2 and Ni-B/Al2O3 amorphous catalysts by impregnation and reduction by KBH4 solution. Their catalytic activities for hydrogenation arenes were tested by the hydrogenation of 1,3,5-trimethylbenzene (TMB) in the co…     

New diterpenoid glucosides from Siegesbeckia pubescens

Plants of the genus Siegesbeckia are annual herbs widely distributed in tropical and temperate zones and they are used as a traditional medicine to treat rheumatic arthritis, hypertension, malaria, neurasthenia and snake-bite in China. In previous papers, we reported on five new ent-kaurane and ent-pimarane diterpenoids, siegesbeckioside, siegesbeckiol and siegesbeckic acid1, orientalin A and B, and eight know compounds2,3. The present paper describes the isolation and structural elucidation …     

Concise Synthesis of(±)-epi-Chrysotricine

Chrysotricine 1 was isolated from the Chinese herb medicine Hedyotis Chrysotricha and was shown to possess antitumor activity1. Its structure has been elucidated as a novel zwitterionic (-carboline alkaloid containing a 2,2,5-trisubstituted tetrahydrofuranyl group. The (-carboline compounds have attracted considerable attraction in recent years because of their promising and intriguing biological activities2. Recently, we have established the absolute configuration of chrysotricine by the fir…