一种香豆素荧光标记多肽的合成及应用

Sirtuin蛋白是一类称为依赖烟酰胺腺嘌呤二核苷酸（NAD）的组蛋白去乙酰化酶,共有7个成员,均是潜在的疾病治疗靶点。 然而,目前的荧光筛选方法,只适用于SIRT1~SIRT3。 因此,根据SIRT5的新酶活,设计、合成了针对SIRT5的荧光标记多肽（ISGASE(SuK) AMC）,并通过LC-MS和荧光检测证明了该荧光标记多肽能应用于SIRT5的活性筛选。     

核磁共振技术在核材料及其湿度检测中的应用研究

核磁共振技术对核材料贮存环境的改善、核废料的长期安全管理具有非常重要的意义。在分析环境因素对铀、钚核材料贮存期间品质变化影响的基础上。探讨了核磁共振方法对核材料进行探测的技术,研究了核材料贮存中湿度的测量和水分子的迁移规律。Nuclear magnetic resonance（NMR） technology play an import role in improving nuclear material stockpile circumstances and long-term security management of nuclear waste materials. Based on analyzing the circumstance factor that influence the qualitative change of the nuclear material of uranium and plutonium during their stockpile, nuclear materials detection technology with NMR method was discussed, and at the same time, moisture measurement and the water molecule moving rule in nuclear materials during their stockpile were also studied with the same method in this paper.     

用MC方法计算铅玻璃对核材料γ射线的屏蔽作用(已撤稿)

核材料辐射出的γ射线对人体有很强的辐射损伤, 实际工作中多用铅玻璃对其进行屏蔽。 以甲状腺为研究对象, 应用蒙特卡罗方法通用软件MCNP4B程序建立模型, 模拟计算了操作人员在操作核弹头时, 弹头中产生的γ射线透过各种厚度的铅玻璃时人体甲状腺吸收剂量率。 结果表明, 铅玻璃确有良好的降低γ射线吸收剂量率的作用。
The γ ray which is radiated from a nuclear material can cause serious radiation damage to human organs, so lead glass are often used as a shielding material. In this paper, thyroid was the subject investigated. A mathematical model was established by using the general software code MCNP4B. We have calculated a series of thyroid’s absorbed dose rate when the γ ray which was generated from the warhead penetrated the various depths of the lead glass via the model. The results indicate that lead glass work well as a protector against γ rays.     

Track reconstruction based on Hough-transform for nTPC

A GEM-TPC prototype, which will be used as a fast neutron spectrometer based on the recoil proton method, is designed and being constructed in Tsinghua University. In order to derive the recoil angle of the recoil proton, tracks of recoil proton in the TPC sensitive volume must be reconstructed. An algorithm based on Hough-transform for track finding and least square method for track fitting was developed in this paper. Based on the Monte Carlo simulation data given by Geant4, a detailed track reconstruction process was introduced and the spectrum of induced fast neutron was derived here. The results show that the algorithm was effective and high-performance. With the recoil angle of the proton less than 30°, a 4.4% FWHM neutron energy resolution was derived for 5 MeV induced fast neutron, and the detection efficiency was about 2×10^-4.     

基于星地测量和辐射传输模式的特定地域大气中分辨力光谱辐射特征

 利用中分辨力成像光谱仪数据,采用星地测量并结合中分辨力辐射传输模式,以巢湖流域及周边为实验区,计算得到该地区夏季实际大气层结下沿观测路径整层大气透过率、大气辐射、大气热辐射和大气散射的太阳辐射在中分辨力光谱上的特征,以及整层大气廓线。研究结果表明：受能见度影响,实验区两地点水体像元处的整层大气透过率数值略高于植被像元处;两地卫星入瞳处的程辐射和卫星探测器探测到的程辐射谱分布相似;在可见至近红外波段,大气程辐射和散射的太阳辐射谱分布相似性较强,且随着波长增加而数值均逐渐减小,而大气热辐射数值很小;两个地点在短波范围内路径热辐射很低且接近,随着波长的增加,热辐射明显增强,波长越长,两地点热辐射差别越明显;当日天气晴好,气溶胶含量较低,而且两地距离很近,因此两地的大气廓线数据基本相似。     

铀的原子模型

在U价电子采用(5s4p3d4f)/[3s3p2d2f]收缩基函数,原子实采用相对论原子实势进行处理的条件下,通过B3LYP杂化交换-相关泛函对U₂分子的电子态和势能数据进行了第一性原理计算．结果表明U₂分子的基态电子态为X⁹∑⁺_g ．同时用Murrell-Sorbie解析势能函数对对势数据进行拟合．在自旋极化水平和广义梯度近似下,采用密度泛函理论(DFT)和Perdew-Burke