全文获取类型
收费全文 | 3525篇 |
免费 | 67篇 |
国内免费 | 1篇 |
专业分类
化学 | 2154篇 |
晶体学 | 38篇 |
力学 | 153篇 |
数学 | 432篇 |
物理学 | 816篇 |
出版年
2022年 | 73篇 |
2021年 | 81篇 |
2020年 | 69篇 |
2019年 | 72篇 |
2018年 | 54篇 |
2017年 | 45篇 |
2016年 | 98篇 |
2015年 | 78篇 |
2014年 | 92篇 |
2013年 | 236篇 |
2012年 | 168篇 |
2011年 | 178篇 |
2010年 | 112篇 |
2009年 | 117篇 |
2008年 | 158篇 |
2007年 | 123篇 |
2006年 | 121篇 |
2005年 | 93篇 |
2004年 | 78篇 |
2003年 | 50篇 |
2002年 | 77篇 |
2001年 | 41篇 |
2000年 | 55篇 |
1999年 | 39篇 |
1998年 | 42篇 |
1997年 | 34篇 |
1996年 | 53篇 |
1994年 | 40篇 |
1993年 | 34篇 |
1992年 | 38篇 |
1991年 | 36篇 |
1990年 | 28篇 |
1989年 | 31篇 |
1988年 | 39篇 |
1987年 | 27篇 |
1985年 | 29篇 |
1984年 | 36篇 |
1983年 | 32篇 |
1982年 | 36篇 |
1981年 | 28篇 |
1979年 | 36篇 |
1978年 | 34篇 |
1977年 | 34篇 |
1976年 | 50篇 |
1975年 | 44篇 |
1974年 | 48篇 |
1973年 | 61篇 |
1972年 | 39篇 |
1971年 | 39篇 |
1970年 | 29篇 |
排序方式: 共有3593条查询结果,搜索用时 3 毫秒
951.
Synthesis of a new catechin-pyrylium derived pigment 总被引:1,自引:0,他引:1
A new catechin-pyrylium derived pigment compound was synthesised from the reaction of catechin with sinapaldehyde in acidic conditions and its structure has been characterised by UV-vis, MS and NMR spectroscopy. Similar compounds could be expected to be formed in wines and contribute to changes in colour and astringency during ageing. 相似文献
952.
Irede Dalmolin Marcio A. Mazutti Eduardo A.C. Batista M. Angela A. Meireles J. Vladimir Oliveira 《The Journal of chemical thermodynamics》2010,42(6):797-801
The aim of this work is to report phase equilibrium experimental results for the systems grape oil/carbon dioxide and (grape oil/carbon dioxide + ethanol). The oil was obtained by supercritical extraction from the grape seed residue from wine production. The static synthetic method using a variable-volume view cell was employed for obtaining the experimental bubble and dew (cloud) points transition data over the temperature range of (313.15 to 343.15) K and pressures up to 20.6 MPa. The experiments were carried out using (ethanol + CO2) overall mass fractions ranging from 0.50 to 0.99, keeping a fixed ethanol to carbon dioxide molar ratio at 1:3. Results indicate the existence of complex phase behaviour for all temperatures investigated with the occurrence of vapour–liquid, liquid–liquid and vapour–liquid–liquid phase transitions observed. 相似文献
953.
T. V. Chernenko N. T. Ul'chenko A. I. Glushenkova U. P. Pratov E. M. Érkenovab 《Chemistry of Natural Compounds》1995,31(1):29-32
The composition and amounts of various classes of lipids of the seeds of Hibiscus sp. have been investigated. Seven classes of neutral lipids, five of phospholipids, and five of glycolipids have been identified and their fatty-acid and triglyceride compositions have been established. The presence has been shown of 16 main types of triacylglycerols and 25 types of epoxyacyldiacylglycerols. An epoxy-18.0 and an epoxy-18:1 acid in a combined amount of 1.4% have been detected among the acids of the free lipids, together with 8.1% of cyclopropenoid acids.Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 40–44, January–February, 1995. Original article submitted October 24, 1994. 相似文献
954.
SD de Souza AM de Souza AC de Sousa AC Sodero LM Cabral MG Albuquerque HC Castro CR Rodrigues 《Molecules (Basel, Switzerland)》2012,17(8):9529-9539
Hologram QSAR models were developed for a series of 36 inhibitors (29 training set and seven test set compounds) of acetyl/butyrylcholinesterase (AChE/BChE) enzymes, an attractive molecular target for Alzheimer's disease (AD) treatment. The HQSAR models (N = 29) exhibited significant cross-validated (AChE, q2 = 0.787; BChE, q2 = 0. 904) and non-cross-validated (AChE, r2 = 0.965; BChE, r2 = 0.952) correlation coefficients. The models were used to predict the inhibitory potencies of the test set compounds, and agreement between the experimental and predicted values was verified, exhibiting a powerful predictive capability. Contribution maps show that structural fragments containing aromatic moieties and long side chains increase potency. Both the HQSAR models and the contribution maps should be useful for the further design of novel, structurally related cholinesterase inhibitors. 相似文献
955.
Scotti L Tullius Scotti M de Oliveira Lima E Sobral da Silva M do Carmo Alves de Lima M da Rocha Pitta I Olímpio de Moura R Gonzaga Batista de Oliveira J Duarte da Cruz RM Bezerra Mendonça Junior FJ 《Molecules (Basel, Switzerland)》2012,17(3):2298-2315
Fifty 2-[(arylidene)amino]-4,5-cycloalkyl[b]thiophene-3-carbonitrile derivatives were screened for their in vitro antifungal activities against Candida krusei and Cryptococcus neoformans. Based on experimentally determined minimum inhibitory concentration (MIC) values, we conducted computer-aided drug design studies [molecular modelling, chemometric tools (CPCA, PCA, PLS) and QSAR-3D] that enable the prediction of three-dimensional structural characteristics that influence the antifungal activities of these derivatives. These predictions provide direction with regard to the syntheses of new derivatives with improved biological activities, which can be used as therapeutic alternatives for the treatment of fungal infections. 相似文献
956.
Hydroethanolic extracts of C. langsdorffii leaves have therapeutic potential. This work reports a validated chromatographic method for the quantification of polar compounds in the hydroethanolic extract of C. langsdorffii leaves. A reliable HPLC method was developed using two monolithic columns linked in series (100 x 4.6 mm - C18), with nonlinear gradient elution, and UV detection set at 257 nm. A procedure for the extraction of flavonols was also developed, which involved the use of 70% aqueous ethanol and the addition of benzophenone as the internal standard. The developed method led to a good detection response as the values for linearity were between 10.3 and 1000 microg/mL, and those for recovery between 84.2 and 111.1%. The detection limit ranged from 0.02 to 1.70 microg/mL and the quantitation limit from 0.07 to 5.1 microg/mL, with a maximum RSD of 5.24%. Five compounds, rutin, quercetin-3-O-alpha-L-rhamnopyranoside, kaempferol-3-O-alpha-L-rhamnopyranoside, quercetin and kaempferol, were quantified. This method could, therefore, be used for the quality control of hydroethanolic extracts of Copaifera leaves and their cosmetic and pharmaceutical products. 相似文献
957.
The solid-fluid coexistence properties of the n - 6 Lennard-Jones system, n from 7 to 12, are reported. The procedure relies on determining Helmholtz free energy curves as a function of volume for each phase independently, from several NVT simulations, and then connecting it to points of known absolute free energy. For n = 12 this requires connecting the simulated points to states of very low densities on the liquid phase, and to a harmonic crystal for the solid phase, which involves many extra simulations for each temperature. For the reference points of the remaining systems, however, the free energy at a given density and temperature can be calculated relative to the n = 12 system. The method presented here involves a generalization of the multiple histogram method to combine simulations performed with different potentials, provided they visit overlapping regions of the phase space, and allows for a precise calculation of relative free energies. The densities, free energies, average potential energies, pressure, and chemical potential at coexistence are presented for up to T? = 5.0 and new estimations of the triple points are given for the n - 6 Lennard-Jones system. 相似文献
958.
959.
Daiane Cristina Sass Vladimir Constantino Gomes Heleno Jader da Silva Barbosa Gustavo Oliveira Morais Fernando Batista Da Costa Mauricio Gomes Constantino 《Tetrahedron letters》2013,54(7):625-627
The conversion of a germacranolide structure (tagitinin C) into a furanoheliangolide one (diversifolin) was achieved by hydride conjugate addition using Stryker’s reagent. 相似文献
960.
Santiago PS Neto Dde S Gandini SC Tabak M 《Colloids and surfaces. B, Biointerfaces》2008,65(2):247-256
Fluorescence quenching of meso-tetrakis-4-sulfonatophenyl (TPPS(4)) and meso-tetrakis-4-N-methylpyridil (TMPyP) porphyrins is studied in aqueous solution and upon addition of micelles of sodium dodecylsulfate (SDS), cetyltrimethylammonium chloride (CTAC), N-hexadecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate (HPS) and t-octylphenoxypolyethoxyethanol (Triton X-100). Potassium iodide (KI) was used as quencher. Steady-state Stern-Volmer plots were best fitted by a quadratic equation, including dynamic (K(D)) and static (K(S)) quenching. K(S) was significantly smaller than K(D). Frequency-domain fluorescence lifetimes allowed estimating bimolecular quenching constants, k(q). At 25 degrees C, in aqueous solution, TMPyP shows k(q) values a factor of 2-3 higher than the diffusional limit. TPPS(4) shows collisional quenching with pH dependent k(q) values. For TMPyP quenching results are consistent with reported binding constants: a significant reduction of quenching takes place for SDS, a moderate reduction is observed for HPS and almost no change is seen for Triton X-100. Similar data were obtained at 50 degrees C. For CTAC-TPPS(4) system an enhancement of quenching was observed as compared to pure buffer. This is probably associated to accumulation of iodide at the cationic micellar interface. The attraction between CTAC headgroups and I(-), and repulsion between SDS and I(-), enhances and reduces the fluorescence quenching, respectively, of porphyrins located at the micellar interface. The small quenching of TPPS(4) in Triton X-100 is consistent with strong binding as reported in the literature. 相似文献