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Nowlin D Bingham P Berridge A Gribbon P Laflin P Sewing A 《Combinatorial chemistry & high throughput screening》2006,9(5):331-337
From a perspective of process knowledge and enhancement, the analysis of the results of biological screening should not be limited to the outcome of specific projects, but additionally encompass a process centric view. Summarising outcomes across multiple projects is a powerful tool to gain a greater understanding of biological screening that will also enable optimisation of the strategy for specific projects or target classes. We have analysed a set of 73,651 compounds with reproducible (confirmed) results from 63 high-throughput screening (HTS) campaigns to reveal the underlying trends in the population of active compounds. We have focused on the overall physico-chemical profile of compound populations derived from biological screening since the in vivo activity of drug molecules is the result of physico-chemical and structural properties of the compound. 相似文献
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Y. V. Kissin R. I. Mink T. E. Nowlin A. J. Brandolini 《Journal of polymer science. Part A, Polymer chemistry》1999,37(23):4281-4294
Ethylene polymerization reactions with many Ziegler–Natta catalysts exhibit a number of features that differentiate them from polymerization reactions of α olefins: (1) a relatively low ethylene reactivity, (2) markedly higher polymerization rates in the presence of α olefins, (3) a high reaction order with respect to ethylene concentration, and (4) a strong reversible rate depression in the presence of hydrogen. A detailed kinetic analysis of ethylene polymerization reactions1 provided the basis for a new kinetic scheme that postulates the equilibrium formation of Ti C2H5 species with the H atom in the methyl group β-agostically coordinated to the Ti atom in an active center. This mechanism predicts several new features of ethylene polymerization reactions, one being that chain initiation via insertion of any α-olefin molecule into the Ti H bond should proceed with an increased probability compared to that via ethylene insertion into the same bond. As a result, a significant fraction of ethylene/α-olefin copolymer chains should contain α-olefin units as the starting units. This article provides experimental data supporting this prediction on the basis of both a detailed structural analysis of co-oligomers formed in ethylene/1-pentene and ethylene/4-methyl-1-pentene copolymerization reactions and a spectroscopic analysis of chain ends in the copolymers. © 1999 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 37: 4281–4294, 1999 相似文献
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Julia M. Nowlin Brown 《Journal of Geometry》1992,43(1-2):41-52
We construct a class of ovals in all Figueroa planes of characteristic not two. This class coincides with the Ovali di Roma of Cherowitzo in the case the Figueroa plane is finite. We also construct a polarity whose set of absolute points is the set of points of the oval.This research was supported by Grant Number A8027, Natural Sciences and Engineering Research Council of Canada 相似文献
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T. E. Nowlin D. Foss Smith Jr. G. S. Cieloszyk 《Journal of polymer science. Part A, Polymer chemistry》1980,18(7):2103-2119
The air oxidation of poly-p-xylylene films was studied at temperatures between 125 and 200°C. The oxidation kinetics were obtained from neutron activation (NA) oxygen analyses and infrared (IR) Spectroscopy. A correlation between the NA oxygen analyses and mechanical properties indicated that the amount of oxygen incorporated into these polymers before a significant degradation mechanical properties is about 1000 ppm for poly(dichloro-p-xylylene) and 5000 ppm for poly(monochloro-p-xylylene) or poly-p-xylylene. The activation energy for the oxidation of these polymers was about 30 kcal/mole. Long-term-use (100,000 hr) temperatures were also estimated for each of the poly-p-xylylenes studied. The 100,000-hr maximum continuous-use temperature is 112°C for poly(dichloro-p-xylylene), 72°C for poly(monochloro-p-xylylene), and 57°C for poly-p-xylylene. 相似文献
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T. E. Nowlin R. I. Mink F. Y. Lo T. Kumar 《Journal of polymer science. Part A, Polymer chemistry》1991,29(8):1167-1173
The amount of dibutylmagnesium (DBM) or triethylaluminum (TEAL) that reacted with silica at 55–60°C depended on the silica calcining temperature. Lower silica calcining temperatures resulted in more Mg or Al fixed to the silica surface, indicating greater amounts of DBM or TEAL reacting with the silica. The amount of the metal alkyls butyl(octyl) magnesium ethoxide, ethylaluminum dichloride, tri-n-hexylaluminum, and diethyl(ethyldimethylsilanolato) aluminum that reacted with 600°C calcined silica was also determined. The metal alkyl can react with the silica at two sites, a surface hydroxyl group and a siloxane group. The silica surface hydroxyl groups can be chemically converted to trimethylsilyl groups so that only the siloxane groups are available for attack. After the metal alkyl was reacted with silica, the resulting intermediate was treated with titanium tetrachloride to yield an ethylene polymerization catalyst in the presence of TEAL. When no metal alkyl was employed, titanium tetrachloride reacted only with the silica surface hydroxyl groups to yield a weakly active ethylene polymerization catalyst. 相似文献
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T. E. Nowlin Y. V. Kissin K. P. Wagner 《Journal of polymer science. Part A, Polymer chemistry》1988,26(3):755-764
High activity ethylene polymerization catalysts have been prepared by the interaction of ethylmagnesium chloride in tetrahydrofuran with high surface area silica, followed by reaction with excess titanium tetrachloride in heptane. The catalysts were tested in ethylene—hexene copolymerization reactions in the presence of AlEt3 at 80°C. For comparison purposes, the copolymerization properties of a similar catalyst prepared without silica were also evaluated. Preparative conditions were identified which provide catalysts that possess high reactivity towards 1-hexane. The silica and the amount of magnesium used in catalyst preparation strongly affect the copolymerization properties of the catalysts. Generally, catalysts prepared with silica showed much higher sensitivity to 1-hexene (effective reactivity ratio r1 = 25–60) while a similar catalyst prepared without silica exhibited an r1 value of 125. Fractionation of the copolymer with a series of boiling solvents showed that all the catalysts exhibit a wide distribution of active centers with respect to reactivity ratios, with the r1 values varying from 5–7 to ca. 200. The width of a the center distribution depends on catalyst composition—it is the narrowest for the catalyst prepared without silica and is the widest for the catalysts with intermediate Ti : Mg ratios. 相似文献