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81.
Ignacio H. Sánchez María Isabel Larraza Fernande Basurto Ricardo Yaf?ez Salvador Avila Ricardo Tovar Pedro Joseph-Nathan 《Tetrahedron》1985,41(12):2355-2359
(±)--methylperezone () was obtained by selective oxidative demethylation of (±)-leucoperezone trimethyl ether (). Compound () was prepared by condensation of 2,3,5-trimethoxytoluene () with 6-methyl-5-hepten-2-one, followed by reductive removal of the tertiary alcohol. The aromatic precursor was prepared in four steps from 2,3-dimethoxytoluene () and, alternatively, in three steps from 5-bromoveratraldehyde (). Racemic and were directly compared with the optically active molecules prepared from natural R(-)-perezone (). 相似文献
82.
Ana Cristina Gmez-Herrero Carlos Snchez-Snchez Frdric Chrioux Jose Ignacio Martínez Jos Abad Luca Floreano Alberto Verdini Albano Cossaro Estelle Mazaleyrat Valrie Guisset Philippe David Simone Lisi Jos Angel Martín Gago Johann Coraux 《Chemical science》2021,12(6):2257
Catechols are ubiquitous substances often acting as antioxidants, thus of importance in a variety of biological processes. The Fenton and Haber–Weiss processes are thought to transform these molecules into aggressive reactive oxygen species (ROS), a source of oxidative stress and possibly inducing degenerative diseases. Here, using model conditions (ultrahigh vacuum and single crystals), we unveil another process capable of converting catechols into ROSs, namely an intramolecular redox reaction catalysed by a Cu surface. We focus on a tri-catechol, the hexahydroxytriphenylene molecule, and show that this antioxidant is thereby transformed into a semiquinone, as an intermediate product, and then into an even stronger oxidant, a quinone, as final product. We argue that the transformations occur via two intramolecular redox reactions: since the Cu surface cannot oxidise the molecules, the starting catechol and the semiquinone forms each are, at the same time, self-oxidised and self-reduced. Thanks to these reactions, the quinone and semiquinone are able to interact with the substrate by readily accepting electrons donated by the substrate. Our combined experimental surface science and ab initio analysis highlights the key role played by metal nanoparticles in the development of degenerative diseases.An antioxidant catechol transforms following intramolecular redox reactions into highly reactive oxygen species, a semiquinone and a quinone, on copper. 相似文献
83.
J. Hidalgo E. Roldan D. Gonzlez-Arjona M. Snchez 《Journal of photochemistry and photobiology. A, Chemistry》1987,41(1)
Quantum yields and lifetimes of several derivatives of the Peganum Harmala and Rauwolfia alkaloids have been measured. The natural lifetimes of these alkaloids have been calculated from a modified form of the Strickler—Berg equation and the results are compared with the observed lifetimes. 相似文献
84.
Sanchiz J Esparza P Villagra D Domínguez S Mederos A Brito F Araujo L Sánchez A Arrieta JM 《Inorganic chemistry》2002,41(23):6048-6055
The coordinating ability of the ligands 3,4-toluenediamine-N,N,N',N'-tetraacetate (3,4-TDTA), o-phenylenediamine-N,N,N',N'-tetraacetate (o-PhDTA), and 4-chloro-1,2-phenylenediamine-N,N,N',N'-tetraacetate (4-Cl-o-PhDTA) (H4L acids) toward lead(II) is studied by potentiometry (25 degrees C, I = 0.5 mol x dm(-3) in NaClO4), UV-vis spectrophotometry, and 207Pb NMR spectrometry. The stability constants of the complex species formed were determined. X-ray diffraction structural analysis of the complex [Pb4(mu-3,4-TDTA)4(H2O)2]*4H2O (1) revealed that 1 has a 2-D structure. The layers are built up by the polymerization of centrosymmetric [Pb4L2(H2O)2] tetranuclear units. The neutral layers have the aromatic rings of the ligands pointing to the periphery, whereas the metallic ions are located in the central part of the layers. In compound 1, two types of six-coordinate lead(II) environments are produced. The Pb(1) is coordinated to two nitrogen atoms and four carboxylate oxygens from the ligand, whereas Pb(2) has an O6 trigonally distorted octahedral surrounding. The lead(II) ion is surrounded by five carboxylate oxygens and a water molecule. The carboxylate oxygens belong to four different ligands that are also joined to four other Pb(1) ions. The selective uptake of lead(II) was analyzed by means of chemical speciation diagrams as well as the so-called conditional or effective formation constants K(Pb)eff. The results indicate that, in competition with other ligands that are strong complexing agents for lead(II), our ligands are better sequestering agents in acidic media. 相似文献
85.
Poly[(2,2'-bipyridine)tetrakis(imidazolato)diiron(II)] was synthesized by the reaction of ferrocene with imidazole in an excess of 2,2'- bipyridine in a Carius tube at 130 degrees C. Dc magnetic susceptibility studies at an applied field of 1000 G reveal that on cooling from room temperature, the material undergoes two structural phase transitions designated alpha --> beta and beta --> gamma at 151 and 133 K, respectively. On warming, the gamma --> beta and beta --> alpha transitions are observed at 137 and 151 K, respectively; a 4 K thermal hysteresis clearly detectable in the lower temperature beta <--> gamma transition. These structural phase transitions have also been studied by detailed, variable-temperature, ac susceptibility and M?ssbauer spectroscopy techniques. Single-crystal X-ray diffraction studies done at 294, 143, and 113 K reveal 2, 12, and 6 unique iron centers in the alpha-, beta-, and gamma-forms, respectively. All three forms have the same basic structure involving 2D extended double layer sheets (bilayers) of alternating tetrahedral and octahedral irons singly bridged by imidazolate ligands, with the octahedral centers additionally coordinated by 2,2'-bipyridine ligands that occupy positions between the sheets. Magnetic susceptibility and bond length data reveal that in the gamma-phase one in three six-coordinate sites corresponds to spin singlet ground-state iron(II); i.e., the overall alpha --> gamma process involves a spin-crossover transition such that at least 1/6 of the iron sites in the gamma-phase correspond to S = 0. This is supported by the low-temperature M?ssbauer spectra of the gamma-phase, which reveal the simultaneous presence of both S = 2 and S = 0 iron(II) centers. The compound magnetically orders, with a resultant small remnant magnetization, at low temperatures. The magnetic phase transition, studied by a combination of dc and ac susceptibility and M?ssbauer techniques, occurs at T(c) approximately 6.5 K. 相似文献
86.
A polypyrrole electrode modified with a tetrasulfonated nickel(II) phthalocyanine complex (GCE/PPy/NiPcTs) was used as amperometric electrochemical detector in a flow injection system, in order to determine some antioxidants in foods. The lather were separated by HPLC and detected at the modified electrode. Previous investigations carried out in our laboratory employed this electrode and cyclic voltammetry (CV), obtaining excellent results, due to an electrocatalytic effect on the oxidation of certain alimentary antioxidants, such tert-butylhydroquinone (TBHQ), 3-tert-butyl-4-hydroxyanisole (BHA) and propylgallate (PG). In order to obtain good separation, the chromatographic conditions were optimised. The geometry of the flow injection analysis (FIA) circuit and the reproducibility of the results were also optimised and, finally, the linear relationship between the signal and the concentration was verified. The proposed procedure is more precise and accurate than the conventional voltammetry methods. These results offer new analytical possibilities to this type of modified electrodes. The developed methods were applied to the determination of these antioxidants in commercial food. 相似文献
87.
Carballo R Casas JS García-Martínez E Pereiras-Gabián G Sánchez A Sordo J Vázquez-López EM 《Inorganic chemistry》2003,42(20):6395-6403
The reactions of methylacetoacetate and ethyl 2-methylacetoacetate thiosemicarbazones (H(2)L(A) and H(2)L(B), respectively) with [ReX(CO)(5)] and [ReX(CO)(3)(CH(3)CN)(2)] (X = Cl, Br) were explored under various experimental conditions. Besides the adducts fac-[ReX(CO)(3)(H(2)L)], in which the rhenium is coordinated to three carbonyl groups, the X anion, and the N,S-bidentate thiosemicarbazone ligand, the following complexes were also isolated: fac-[ReBr(CO)(3)(Hpyz(B))], the tetrameric complexes fac-[Re(pyz(A))(CO)(3)](4) and fac-[Re(pyz(B))(CO)(3)](4), and fac-[Re(pyz(B))(CO)(3)(H(2)O)] (where Hpyz(A) and Hpyz(B) are pyrazolones derived by cyclization of H(2)L(A) and H(2)L(B), respectively). The cyclization reactions were monitored by (1)H NMR spectroscopy and the complexes isolated were identified by elemental analysis, mass spectrometry, IR and (1)H NMR spectroscopy, and in some cases by X-ray diffractometry. The isolation and the full structural identification of the rather unusual fac-[ReBr(CO)(3)(Hpyz(B))], which contains the enol form of the pyrazolone ligand, affords new insight into the cyclization of thiosemicarbazones derived from beta-keto esters. 相似文献
88.
Five new representatives of the cembrane class of marine natural products have been isolated as minor metabolites from an undescribed species of Eunicea, a sea whip collected near the Colombian Southwestern Caribbean Sea. The structure of the crystalline metabolite 1 was solved by single-crystal X-ray diffraction analysis. Structures could then be proposed for cembradienes 2-5 by comprehensive spectral analyses involving 2D NMR, IR, UV, and high-resolution mass spectrometry, as well as chemical interconversion studies. Compound 1 exhibited weak cytotoxicity in the NCI 3-cell line panel human cancer screening program, whereas compounds 1, 2 and 4 displayed significant antiplasmodial activity against Plasmodium falciparum. 相似文献
89.
Maria Luisa Moyá Antonio Barrios Maria del Mar Graciani Rafael Jiménez Ernestina Muñoz Francisco Sánchez John Burgess 《Transition Metal Chemistry》1991,16(2):165-168
Summary The kinetics of replacement of 4,4-bipyridine, (4,4-bipy), and 4-cyanopyridine, (4-CNpy), by cyanide in [Fe(CN)5-(4,4-bipy)]3-. at 298 K have been studied in binary aqueous mixtures containing different amounts of t-butanol, methanol, glycerol, ethyleneglycol and sucrose. The plots of logarithms of the limiting rate constantsversus the mole fraction of water are linear over the entire composition range studied, showing the importance of solvation phenomena. A different straight line of log (kL/s–1)versus XH2O is obtained for each mixture, indicating the influence of other solvent parameters on the reaction rate. A multiparameter regression of G
exp
with A (acidity vector), B (basicity vector) and GE is used for both reactions; plots of G
calc
versus G
exp
are linear with slopes of near unity. 相似文献
90.
Philippe Quevauviller Gemma Rauret Allan Ure Roser Rubio José-Fírmin López-Sánchez Haidé Fiedler Herbert Muntau 《Mikrochimica acta》1995,120(1-4):289-300
The determination of extractable trace metal contents in soil using single extraction procedures is currently performed in many laboratories to assess the bioavailable metal fraction (and related phytotoxic effects) and the accessability to the environment (e.g. contamination of ground waters). Owing to the need for validation of the extraction schemes used and of the analytical techniques, the EC Measurements and Testing Programme (formerly BCR) has organized a project for improving the quality of determination of extractable trace metal contents in soil, the first step being an interlaboratory study to adopt common extraction procedures and the second being a certification campaign to certify two soils for their extractable trace element contents following these procedures. This paper gives a brief overview of the project organisation and describes the preparation, homogeneity and stability studies of two soil candidate reference materials (sewage sludge-amended and terra rossa soils). 相似文献