Copper(I)-mediated preparation of new pyrano[3',4':4,5]imidazo[1,2-a]pyridin-1-one compounds under mild palladium-free conditions

A general and efficient Cu(I)-mediated cross-coupling and heterocyclization reaction of 3-iodoimidazo[1,2-a]pyridine-2-carboxylic acid, and terminal alkynes was developed under very mild conditions. This method allows the introduction in one pot of a third ring fused in positions 2 and 3 of the imidazo[1,2-a]pyridine core with reasonable yields and total regioselectivity. This procedure does not require the use of any expensive supplementary additives, and is palladium-free.     

New semifluorinated dithiols self-assembled monolayers on a copper platform

New alpha,omega-semifluorinated dithiols HS-(CH2)11-(CF2)n-(CH2)11-SH, called DTn, and corresponding dithioacetate molecules CH3COS-(CH2)11-(CF2)n-(CH2)11-SCOCH3, called DTAn ( n = 4, 6, 8), were synthesized and used to create self-assembled monolayers (SAMs) on both untreated copper surfaces and electrochemically reduced ones. The aim of this study is to assess the organization of the resulting SAMs, particularly the effect of the presence of two perhydrogenated segments surrounding the perfluorinated one, and the ability of these difunctional molecules to bind copper substrates by only one end per molecule. In each case, the organization of the SAM is rather poor and only DTA8 molecules seem to adopt an upright position on reduced copper. In addition, the layers have been investigated by cyclic voltammetry (CV) to assess their coverage. DT4 SAMs reveal a covering ratio higher than 99%.     

On the set of <Emphasis Type="Italic">t</Emphasis>-linked overrings of an integral domain

Let R be an integral domain with quotient field L. An overring T of R is t-linked over R if I ⁻¹ = R implies that (T : IT)  =  T for each finitely generated ideal I of R. Let O _t (R) denotes the set of all t-linked overrings of R and O(R) the set of all overrings of R. The purpose of this paper is to study some finiteness conditions on the set O _t (R). Particularly, we prove that if O _t (R) is finite, then so is O(R) and O _t (R) = O(R), and if each chain of t-linked overrings of R is finite, then each chain of overrings of R is finite. This yields that the t-linked approach is more efficient than the Gilmer’s treatment (Proc Am Math Soc 131:2337–2346, 2002). We also examine the finiteness conditions in some Noetherian-like settings such as Mori domain, quasicoherent Mori domain, Krull domain, etc. We establish a connection between O _t (R) and the set of all strongly divisorial ideals of R and we conclude by a characterization of domains R that are t-linked under all their overrings. This work was funded by KFUPM under Project # FT/18-2005.     

A Potentiometric and Spectroscopic Investigation of Copper(II)– and Zinc(II)–Orotate Complex Equilibria Under Physiological Conditions

A quantitative study of zinc(II) and copper(II) complex formation with orotic acid has been performed under physiological conditions (37°C; 0.15 mol-dm^–3 NaCl) using the glass electrode potentiometric technique. Several species have been identified within the pH range 2–10 for the metal-to-ligand concentration ratios investigated. Three mononuclear complexes, ML, ML₂, and ML₂H_–1, have been characterized with both metals. In addition, the polynuclear species M₃L₂H_–2 has been found with copper(II). Formation constants for all these species have been calculated with the help of the SUPERQUAD computer program. UV absorption and IR spectroscopic measurements combined with speciation calculations have been used to confirm corresponding structures.     

Metallodynameric membranes--toward the constitutional transport of gases

The adequate selection of macromonomers, dialdehyde core connectors and of coordinating metal ions makes possible the generation of metallodynameric materials, allowing the fine modulation of the gas transport through rubbery membranes.     

Synthesis of New N-Sulfonyl Monocyclic β-Lactams and the Investigation of Their Antibacterial Activities

New monocyclic β-lactams 4–6 were synthesized by a ketene-imine [2+2] cycloaddition reaction. The prepared monocyclic β-lactams 4–6 were cleaved by ceric ammonium nitrate (CAN) to give NH-β-lactams 7–9. The NH-β-lactams were converted to N-sulfonyl β-lactams 10–21 by treatment with four different sulfonyl chlorides in the presence of Et₃N and 4-N,N-dimethylaminopyridine (DMAP). Some of these monocyclic β-lactams were active against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa.

Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.     

H6P2W18O62·14H2O as an efficient catalyst for the green synthesis of α-aminophosphonates from α-amino acids

Abstract

A simple, efficient and eco-friendly protocol has been described for the synthesis of α-aminophosphonates via Kabachnik-Fields reaction, catalyzed by H₆P₂W₁₈O₆₂·14H₂O as a reusable catalyst. The reaction was realized by condensation of amino acids, various aromatic aldehydes and triethylphosphite under solvent-free conditions, the corresponding α-aminophosphonates were formed in good yields. All the new products were characterized by IR, ¹H, ¹³C and ³¹P-NMR analyses. This method offers advantages such as simplicity workup with the green aspects, good yields and short reaction times.