Preparation of nanometer FeCuP alloy and its application in decomposition of PH3

A new ternary Fe-based alloy catalyst FeCuP applied to decompose PH_3 was prepared with low-cost material by chemical reduction deposition method.The properties of it were characterized by XRD,ICP and SEM.Its catalytic activity on the decomposition of PH_3 and the decomposition conditions were studied.FeCuP alloy exhibits high thermal stabilities and high catalytic activity.Using it as catalyst,the decomposition temperature of phosphine decreases from over 800℃to 400-500℃.The decomposition rate of phosphine achieved 100%.     

16-脱氢孕烯醇酮醋酸酯的环境友好合成法

Instead of environmentally toxic chromium oxidant, singlet oxygen generated photcchemically was used as environmentally friendly and benign oxidizing agent to accomplish the transformation of pseudodiosgenin diacetate to diosone efficiently in a low toxic and less expensive solvent acetone. Accordingly 16-dehydropregnenolone acetate(16-DPA), an important intermediate for preparation of steroidal drugs, was prepared in good yield (75%) when photoreaction was run in acetone/acetic anhydride/pyridine system. The mild reaction condition as well as simple and environmentally friendly process made the method commercially viable and important for production of 16-DPA in industrial scale.     

Influence of organic bases on constructing 3D photoluminescent open metal-organic polymeric frameworks

Four three-dimensional non-interpenetrating open coordination frameworks constructed from the CTC ligand (CTC =cis,cis-1,3,5-cyclohexanetricarboxylate) coordinated to metal ions (Mn(II) and Cd(II)): Mn(3)(CTC)(2)(DMF)(2)(1); Cd(3)(CTC)(2)(H(2)O)(3).H(2)O (2); Cd(3)(CTC)(2)(4,4'-bpy)(2)(EG)(2)(3); Cd(3)(CTC)(2)(mu(2)-hmt)(DMF)(C(2)H(5)OH)(H(2)O).2H(2)O (4)(DMF = dimethylformamide and EG = ethylene glycol) have been synthesized by slow evaporation of DMF-C(2)H(5)OH-H(2)O solutions of M(II)(Mn(II) or Cd(II)) and CTC in the presence of the organic bases TEA (triethylamine), TEA, 4,4'-bpy (4,4'-bipyridine) and hmt (hexamethylenetetramine), respectively, and structurally characterized by X-ray crystallography. The polymer constructed by CTC and Mn(II) exhibits a 3-D architecture with 5 x 9 A channels; the polymer formed by CTC and Cd(II) exists a 3-D extended framework with 9 x 9 A channels; wave-like sheet subunits of the polymer are upheld by 4,4'-bpy ligands resulting in a 3-D framework with 4 x 10 A channels; two-fold alternate sheet subunits of the polymer are interlinked by mu(2)-hmt ligands to form a novel 3-D architecture with 7 x 8 A channels. Polymers exhibit their strongest excitation peaks at 391, 390 and 394 nm, respectively, and their main strong emission peaks are at 543, 460 (with a shoulder peak at about 570 nm) and 557 nm, respectively.     

IR, MS studies on (+/-)-1-[3-(2-methoxyphenoxy)-2-hydroxypropyl]-4-[(2,6-dimethylphenyl)aminocarbonylmethyl]piperazine dihydrochloride salt

The vibration spectrum and FAB mass spectrum of (+/-)-1-[3-(2-methoxyphenoxy)-2-hydroxypropyl]-4-[(2,6-dimethylphenyl)aminocarbonylmethyl]piperazine dihydrochloride salt was studied. By comparing with the spectra of free base, different bands of IR were found in the NH+ stretching, the NH+ deformation motion, the CH2 of NCH2 group symmetric stretching, the CH2 of N-CH2 group twisting and the CN stretching. FAB shows the basic peak is M + H. Other m/e peaks are consistent with the structure.     

Effects of organic solvents on the structure stability of TS-1 for the ammoximation of cyclohexanone

The effects of organic solvents on the ammoximation of cyclohexanone to cyclohexanone oxime with H₂O₂and NH₃ over TS-1 were studied. To investigate the effects of ammonia and organic solvents on the structure stability of the catalyst, TS-1 samples were pretreated under severe conditions in ammonia solution or ammonia solution plus methanol, toluene or t-butanol, respectively, and then characterized bySEM, XRD, FTIR, etc. The results revealed that t-butanol is the best solvent for the ammoximation reaction; ammonia tends to destroy the active sites, -Ti-O-Si- structure in TS-1, but the presence of organic solvents remarkably limits this damaging effect of ammonia.     

聚苯乙烯磺酸掺杂聚苯胺的合成

以苯胺（An）为单体，过硫酸铵（APS）为氧化剂，在聚苯乙烯磺酸（PSSA）的水溶液中，合成了可完全溶于水的PSSA掺杂PAn。研究了An浓度，PSSA浓度，APS浓度，APS的滴加时间，反应时间及温度对An聚合反应及其产物的水溶性，导电性及特性粘度[η]的影响。结果表明：在比较宽的实验条件下，都可以合成出具有良好导电性的可溶于水的PSSA掺杂PAn；其中当An：PSSA:APS的摩尔比为1．7：2．5：1，APS溶液的滴加时间为3h，反应时间为1h，反应温度为14℃时，得到的掺杂PAn导电率最高达0．156S／cm。     

Modulation of the lifespan of C. elegans by the controlled release of nitric oxide

The frontier of nitric oxide biology has gradually shifted from mechanism elucidation to biomanipulation, e.g. cell-proliferation promotion, cell-apoptosis induction, and lifespan modulation. This warrants biocompatible nitric oxide (NO) donating materials, whose NO release is not only controlled by a bioorthogonal trigger, but also self-calibrated allowing real-time monitoring and hence an onset/offset of the NO release. Additionally, the dose of NO release should be facilely adjusted in a large dynamic range; flux and the dose are critical to the biological outcome of NO treatment. Via self-assembly of a PEGylated small-molecule NO donor, we developed novel NO-donating nanoparticles (PEG-NORM), which meet all the aforementioned criteria. We showcased that a low flux of NO induced cell proliferation, while a high flux induced cell oxidative stress and, ultimately, death. Notably, PEG-NORM was capable of efficiently modulating the lifespan of C. elegans. The average lifespan of C. elegans could be fine-tuned to be as short as 15.87 ± 0.29 days with a high dose of NO, or as long as 21.13 ± 0.41 days with a low dose of NO, compared to an average life-span of 18.87 ± 0.46 days. Thus, PEG-NORM has broad potential in cell manipulation and life-span modulation and could drive the advancement of NO biology and medicine.

Schematic illustration of modulating the longevity of the C. elegans by PEG-NORM nanoparticles.     

3－苯氧甲基－6－（2，4－二氟苯基）－7H-1,2,4-三唑并[3,4-b][1,3,4]噻二嗪的合成与晶体结构研究

由苯氧乙酸出发，经多步反应，制得3-苯氧甲基－4－氨基－5－巯基－1，2， 4－三唑，它与2-氯－2'，4'－二氟苯乙酮进行环化反应，生成3-苯氧甲基－6－（ 2,4-二氟苯基）－7H-1,2,4-三唑并[3,4-b][1,3,4]噻二嗪，通过元素分析、红外 光谱、核磁共振氢谱与碳谱、质谱进行表征，并利用单晶X射线衍射法测定其结构 。晶体属单斜晶系、P2_(1/c)空间群，a = 1.339(3) nm, b = 1.4683(4) nm, c = 0.8606(2) nm, β = 108.49(2)°, Z = 4, F(000) = 736, R_1 = 0.0509。还 对均三唑并噻二唑两类稠杂环的晶体结构作了比较。     

On-line nanoliter cycle sequencing reaction with capillary zone electrophoresis purification for DNA sequencing

An integrated system for DNA sequencing based on a nanoreactor for cycle-sequencing reaction coupled with on-line capillary zone electrophoresis (CZE) for purification and capillary gel electrophoresis (CGE) for separation is presented. Less than 100 nl of premixed reagent solution, which includes dye-labeled terminator pre-mix, bovine serum albumin and template, was hydrodynamically injected into a fused-silica capillary (75 microm I.D.) inside a laboratory-made microthermocycler for cycle sequencing reaction. In the same capillary, the reaction products were purified by CZE followed by on-line injection of the DNA fragments into another capillary for CGE. Over 540 base pairs (bp) of DNA can be separated and the bases called for single-standed DNA with 0.9% error rate. The total time was about 3.5 h, or a cycle time of 2 h with staggered operation. For double-stranded DNA, a longer reaction time was required and base calling up to 490 bp with 1.2% error rate was achieved. The whole system is readily adaptable to automated multiplex operation for DNA sequencing or polymerase chain reaction analysis.     

The formation of a compact polymer film on a copper electrode from benzimidazole solution

The effects of the pretreatment of copper in benzimidazole solutions on the anodic reactions have been observed. The structures of the chemisorbed benzimidazole on copper were studied by using the infrared reflection-absorption technique and X-ray photoelectron spectroscopy. It was found that a compact film of benzimidazolato copper(I) was formed on the copper surface when copper was immersed in a stirred benzimidazole solution and cyclic voltammetry applied. This compact polymer film inhibited anodic oxidation effectively.