排序方式: 共有71条查询结果,搜索用时 15 毫秒
41.
Ruoxi Li Dazheng Ling Tongke Tang Zhenghui Huang Manjiong Wang Fei Mao Jin Zhu Lubin Jiang Jian Li Xiaokang Li 《中国化学快报》2021,32(5):1660-1664
Antimalarial chemotherapies endowed with effectiveness against drug-resistant parasites and good safety are urgently required in clinical.Our previous research revealed that clinical phase II antitumor drug Quisinostat was a promising antimalarial prototype by inhibiting the activity of Plasmodium falciparum(P.falciparum) histone deacetylase(PfHDAC).Herein,30 novel spirocyclic linker derivatives were designed and synthesized based on Quisinostat as lead compound,and then their antimalarial activities and cytotoxicity were systematically evaluated.Among them,compounds 8 and 27 could effectively eliminate wild-type and multi-drug resistant P.falciparum parasites,and display weakened cytotoxicity and good metabolic stability.Western blot assay demonstrated that they could inhibit PfHDAC activity like Quisinostat.In addition,both 8 and 27 showed certain antimalarial efficacy in rodent malaria model,and the animal toxicity of 8 was significantly improved compared with Quisinostat.Overall,8 and 27 were structurally novel PfHDAC inhibitors and provided prospective prototype for further antimalarial drug research. 相似文献
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采用逐层涂布、 分层控制固化程度的方法, 利用聚酰胺酸(PAA, 聚酰亚胺前体)溶液和含有氧化石墨烯(GO)的PAA溶液制备了一系列由高绝缘性PI层与GO@PI介电层交替组合而成的界面清晰且紧密衔接的多层复合薄膜. 通过调控介电层中GO含量及分层结构, 使多层复合薄膜兼具高介电常数和高击穿强度特征. 结果表明, 三层复合薄膜PI/1.0GO@PI/PI的击穿强度为261.5 kV/mm, 储能密度达到1.27 J/cm3, 与相同介电层厚度的单层薄膜相比, 击穿强度和储能密度分别提高了97%和144%, 同时, 其介电损耗也保持在较低水平(tanδ=0.0079). 绝缘层和高介电常数层的协同作用提升了氧化石墨烯/聚酰亚胺复合薄膜的储能密度. 这种简单的多层结构设计有利于氧化石墨烯/聚合物复合材料在介质储能领域的应用. 相似文献
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最近,我校进行了自建校以来首次高中化学实验操作竞赛。中学化学教学大纲要求加强演示实验和学生实验,以使学生能更好地理解知识、发展智力和培养能力。 相似文献
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要实现光参量啁啾脉冲放大(OPCPA)系统稳定、高质量输出,需要同时对光参量放大和泵浦光倍频这两个非线性过程进行优化设计。在光参量放大系统优化设计中,建立了描述光参量放大过程的多种简化物理模型;通过模拟泵浦光和信号光口径匹配关系,分析了放大信号光空间两维对称性并提出了优化方法;建立了非线性晶体最佳长度确定及调谐方法,以实现信号光输出高稳定性。在泵浦光倍频系统优化设计过程中,提出应用位相失配法实现稳定倍频输出,研究表明这种方法不仅能实现倍频光能量起伏抖动远远小于基频光能量的起伏抖动,而且能减小泵浦光近场调制度和时间波形调制,极大地改善输出倍频光光束质量,进而提高OPCPA系统输出信号光质量。 相似文献
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Zhendong Luo Hong Li Yanjie Zhou Zhenghui Xie 《Journal of Mathematical Analysis and Applications》2012,385(1):371-383
A proper orthogonal decomposition (POD) method is applied to a usual finite element (FE) formulation for two-dimensional solute transport problems with real practical applied background such that it is reduced into a reduced FE formulation with lower dimensions and high enough accuracy. The error estimates between the reduced POD FE solutions and the usual FE solutions are provided. It is shown by numerical examples that the results of numerical computation are consistent with theoretical conclusions. Moreover, it is also shown that this validates the feasibility and efficiency of POD FE method. 相似文献
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A proper orthogonal decomposition(POD) method was successfully used in the reduced-order modeling of complex systems.In this paper,we extend the applications of POD method,namely,apply POD method to a classical finite element(FE) formulation for second-order hyperbolic equations with real practical applied background,establish a reduced FE formulation with lower dimensions and high enough accuracy,and provide the error estimates between the reduced FE solutions and the classical FE solutions and the implementation of algorithm for solving reduced FE formulation so as to provide scientific theoretic basis for service applications.Some numerical examples illustrate the fact that the results of numerical computation are consistent with theoretical conclusions.Moreover,it is shown that the reduced FE formulation based on POD method is feasible and efficient for solving FE formulation for second-order hyperbolic equations. 相似文献
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Liang Y Liang F Wu D Li Z Xu F Fu R 《Physical chemistry chemical physics : PCCP》2011,13(19):8852-8856
A unique hierarchical architecture is successfully constructed in a wormhole-like mesopore structure via a multiple nanocasting route. This novel type of hierarchical porous carbon (HPC) consists of three-dimensional ordered macropores (ca. 150 nm) with interconnecting pore windows, and the walls of these macropores are rich in wormhole-like mesopores (ca. 2.7 nm) and large spherical mesopores (ca. 10 nm), as well as a significant microporosity, presenting a macro-meso-microporous structure with a three-dimensional interconnectivity. Such a hierarchically porous structure may provide fine diffusion pathways for reaction species, which is demonstrated by the experimental result of an enhanced performance in a supercapacitor. For example, with the introduction of a hierarchical porous structure for fast transport and effective access of ions, the as-prepared HPC exhibits a specific capacitance as high as 247 F g(-1), whereas traditional wormhole-like mesoporous carbon has only a specific capacitance of 176 F g(-1). 相似文献
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Luo Zhenghui Sun Rui Zhong Cheng Liu Tao Zhang Guangye Zou Yang Jiao Xuechen Min Jie Yang Chuluo 《中国科学:化学(英文版)》2020,63(3):361-369
The emergence of the latest generation of small-molecule acceptor(SMA) materials,with Y6 as a typical example,accounts for the surge in device performance for organic solar cells(OSCs).This study proposes two new acceptors named Y6-C2 and Y6-C3,from judicious alteration of alkyl-chains branching positions away from the Y6 backbone.Compared to the Y6,the Y6-C2 exhibits similar optical and electrochemical properties,but better molecular packing and enhanced crystallinity.In contrast,the Y6-C3 shows a significant blue-shift absorption in the solid state relative to the Y6 and Y6-C2.The as-cast PM6:Y6-C2-based OSC yields a higher power conversion efficiency(PCE) of 15.89% than those based on the Y6(15.24%) and Y6-C3(13.76%),representing the highest known value for as-cast nonfullerene OSCs.Prominently,the Y6-C2 displays a good compatibility with the PC_(71)BM.Therefore,a ternary OSC device based on PM6:Y6-C2:PC_(71)BM(1.0:1.0:0.2) was produced,and it exhibits an outstanding PCE of 17.06% and an impressive fill factor(FF) of 0.772.Our results improve understanding of the structureproperty relationship for state-of-the-art SMAs and demonstrate that modulating the structure of SMAs via fine-tuning of alkylchains branching positions is an effective method to enhance their performance. 相似文献
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