A Comprehensive Review of Rosmarinic Acid: From Phytochemistry to Pharmacology and Its New Insight

Polyphenolic acids are the widely occurring natural products in almost each herbal plant, among which rosmarinic acid (RA, C₁₈H₁₆O₈) is well-known, and is present in over 160 species belonging to many families, especially the Lamiaceae. Aside from this herbal ingredient, dozens of its natural derivatives have also been isolated and characterized from many natural plants. In recent years, with the increasing focus on the natural products as alternative treatments, a large number of pharmacological studies have been carried out to demonstrate the various biological activities of RA such as anti-inflammation, anti-oxidation, anti-diabetes, anti-virus, anti-tumor, neuroprotection, hepatoprotection, etc. In addition, investigations concerning its biosynthesis, extraction, analysis, clinical applications, and pharmacokinetics have also been performed. Although many achievements have been made in various research aspects, there still exist some problems or issues to be answered, especially its toxicity and bioavailability. Thus, we hope that in the case of natural products, the present review can not only provide a comprehensive understanding on RA covering its miscellaneous research fields, but also highlight some of the present issues and future perspectives worth investigating later, in order to help us utilize this polyphenolic acid more efficiently, widely, and safely.     

Syntheses,Structures and Photocatalytic Degradation Properties of Two Copper(Ⅱ)Coordination Polymers with Flexible Bis(imidazole)Ligand

Two copper(Ⅱ)coordination polymers{[Cu(bib)(nip)]·1.5H2O}n(1)and[Cu2(bib)(glu)2]n(2)(bib= 1,4-bis(2-methyl-imidazol-1-yl)butane,H2nip = 5-nitroisophthalic acid,...     

铜电路板缝腐蚀过程缝隙中pH、Cl-浓度分布的测量

根据铜电路板缝腐蚀特征,研制了阵列式Ag/AgCl、IrO2电极,设计缝隙腐蚀模拟装置,在0.5mol.L-1的NaCl溶液中分别同时原位检测电子线路板缝隙腐蚀过程,缝隙内的氯离子浓度分布、pH分布及其随时间的变化.研究表明,在电子线路板发生缝隙腐蚀的过程中,缝隙内部不同深度的Cl-及H+浓度逐渐增大,且随着与缝口距离的增大而增大,从而导致缝隙腐蚀不断向纵深方向发展.     

A DIFFUSIVE SVEIR EPIDEMIC MODEL WITH TIME DELAY AND GENERAL INCIDENCE

In this paper,we consider a delayed diffusive SVEIR model with general inci-dence.We first establish the threshold dynamics of this model.Using a Nonstandard Fi...     

Weak Graph Map Homotopy and Its Applications∗

The authors introduce a notion of a weak graph map homotopy (they call it M-homotopy), discuss its properties and applications. They prove that the weak graph map homotopy equivalence between graphs coincides with the graph homotopy equivalence defined by Yau et al in 2001. The difference between them is that the weak graph map homotopy transformation is defined in terms of maps, while the graph homotopy transformation is defined by means of combinatorial operations. They discuss its advantages over the graph homotopy transformation. As its applications, they investigate the mapping class group of a graph and the 1-order MP-homotopy group of a pointed simple graph. Moreover, they show that the 1-order MP-homotopy group of a pointed simple graph is invariant up to the weak graph map homotopy equivalence.     

复数星图与单路的多染色拉姆齐数

对给定的简单图$H_1,H_2,\ldots,H_c$, 我们将使完全图$K_n$的任意边分解$\{G_i\}^c_{i=1}$都存在至少一个$G_i$有子图同构于$H_i$的最小正整数$n$称为多染色拉姆齐数 $R(H_1,H_2,\ldots,$ $H_c)$. 对正整数$m,n_1,n_2,\ldots,n_c$, 令$\Sigma=\sum_{i=1}^{c}(n_i-1)$. 在文献中,我们已经获得了$R(K_{1,n_1},\ldots,K_{1,n_c},P_m)$ 的一些界和精确值.Wang推测若$\Sigma\not\equiv 0\pmod{m-1}$且$\Sigma+1\ge (m-3)^2$, 则有$R(K_{1,n_1},\ldots, K_{1,n_c}, P_m)=\Sigma+m-1.$ 本文中, 我们给出了一个新的下界并给出$R(K_{1,n_1},\ldots,K_{1,n_c},P_m)$在$m\leq\Sigma$, $\Sigma\equiv k\pmod{m-1}$且$2\leq k \leq m-2$情况下的部分精确值. 这些结果部分证实了Wang的猜想.     

埋地热油管道正常运行的数值模拟研究

对高凝原油管道输送的水力热力问题进行分析研究,掌握管线运行规律,保证管线安全经济运行有着重要意义.本文建立了埋地热油管道正常运行的数学模型,采用非结构化网格和有限容积法对该问题进行了研究,计算结果与实验测量值吻合良好.     

流动注射停流-催化光度法测定环境水样中痕量Mn(Ⅱ)的研究

在碱性介质中,Mn(Ⅱ)对催化KIO4氧化镁试剂Ⅰ(对硝基苯偶氮间苯二酚)的褪色反应有显著作用。据此建立了测定痕量Mn(Ⅱ)的流动注射停流-催化光度法。优化了流动注射条件,Mn(Ⅱ)在2~10μg/L,10~160μg/L,160~1000μg/L范围内符合比尔定律,采样频率6样/h,检出限0.12μg/L,相对标准偏差(RSD)4.9%(n=6)。用于环境水样中Mn(Ⅱ)的检测,回收率为95.5%~102%。     

α-氨基膦酸酯的合成方法研究进展

从Lewis催化剂合成法、非Lewis催化剂合成法、绿色合成法3个方面综述了近年来国内外在α-氨基膦酸酯合成研究领域的最新进展.参考文献33篇.     

Variable Separation and Exact Separable Solutions for Equations of Type uxt=A(u,ux)uxx+B(u,ux)

The generalized conditional symmetry is developed to study the variable separation for equations of type u_xt=A(u,u_x)u_xx+B(u,u_x). Complete classification of those equations which admit derivative-dependent functional separable solutions is obtained and some of their exact separable solutions are constructed.