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排序方式: 共有506条查询结果,搜索用时 46 毫秒
111.
Yosuke Hisamatsu 《Tetrahedron letters》2007,48(4):617-621
A new macrocyclic host, which contains a 2,6-bis(oxazol-2-yl)pyridine unit and a 2,7-dialkoxynaphthalene unit tethered by the appropriate length of alkyl side chains is prepared. This host undergoes highly selective complex formation with an adenine nucleobase, accompanied by a fluorescence response in CHCl3 by a combination of multiple hydrogen bonding and π-π stacking interactions. 相似文献
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114.
Ayako Oda Yosuke Suzuki Banri Sato Haruki Sato Ryota Tanaka Hiroyuki Ono Tadasuke Ando Toshitaka Shin Hiromitsu Mimata Hiroki Itoh Keiko Ohno 《Journal of separation science》2022,45(10):1672-1682
Indoxyl sulfate and 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid are uremic toxins that accumulate in renal failure and have been reported to decrease the activities of the drug-metabolizing enzyme cytochrome P450 3A and the drug transporter organic anion transporting polypeptides 1B, respectively. In this study, we established and validated an assay for simultaneous quantification of indoxyl sulfate and 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid in human plasma. The samples were pretreated by solid-phase extraction, and measured by ultra-high-performance liquid chromatography–tandem mass spectrometry. The validation results for this assay were within the acceptable limits recommended by the US Food and Drug Administration, with a lower limit of quantitation of 0.05 μg/mL for both indoxyl sulfate and 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid. Recovery rates of indoxyl sulfate and 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid corrected by internal standard were 100.7–101.9 and 100.2–101.3%, respectively. Matrix effects of indoxyl sulfate and 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid corrected by internal standard were 101.1–105.5 and 97.0–103.8%, respectively. The validated assay was used to analyze indoxyl sulfate and 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid concentrations in the plasma samples of healthy volunteers and patients with chronic kidney disease. All the measured plasma indoxyl sulfate and 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid concentrations were within the calibration ranges. This novel method may contribute to predicting the activities of drug-metabolizing enzymes and drug transporters in individual patients. 相似文献
115.
Hanqiao Xu Dr. Takashi Kurohara Reina Takano Dr. Hidetomo Yokoo Dr. Norihito Shibata Dr. Nobumichi Ohoka Dr. Takao Inoue Prof. Mikihiko Naito Dr. Yosuke Demizu 《ChemistryOpen》2022,11(7):e202200131
Optimizing linker design is important for ensuring efficient degradation activity of proteolysis-targeting chimeras (PROTACs). Therefore, developing a straightforward synthetic approach that combines the protein-of-interest ligand (POI ligand) and the ligand for E3 ubiquitin ligase (E3 ligand) in various binding styles through a linker is essential for rapid PROTAC syntheses. Herein, a solid-phase approach for convenient PROTAC synthesis is presented. We designed azide intermediates with different linker lengths to which the E3 ligand, pomalidomide, is attached and performed facile PROTACs synthesis by forming triazole, amide, and urea bonds from the intermediates. 相似文献
116.
Guijun Ma Yohichi Suzuki Rupashree Balia Singh Aki Iwanaga Yosuke Moriya Tsutomu Minegishi Jingyuan Liu Takashi Hisatomi Hiroshi Nishiyama Masao Katayama Kazuhiko Seki Akihiro Furube Taro Yamada Kazunari Domen 《Chemical science》2015,6(8):4513-4518
The particulate semiconductor La5Ti2CuS5O7 (LTC) with a band gap energy of 1.9 eV functioned as either a photocathode or a photoanode when embedded onto Au or Ti metal layers, respectively. By applying an LTC/Au photocathode and LTC/Ti photoanode to, respectively, photoelectrochemical (PEC) water reduction and oxidation concurrently, zero-bias overall water splitting was accomplished under visible light irradiation. The band structures of LTC/Au and LTC/Ti calculated using a semiconductor device simulator (AFORS-HET) confirmed the critical role of the solid/solid junction of the metal back contact in the charge separation and PEC properties of LTC photoelectrodes. The prominently long lifetime of photoexcited charge carriers in LTC, confirmed by transient absorption spectroscopy, allowed the utilization of both photoexcited electrons and holes depending on the band structure at the solid/solid junction. 相似文献
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118.
Munetoshi Seki Masateru Mikami Fujiyuki Iwamoto Yosuke Ono Takamasa Osone Hitoshi Tabata 《Journal of Crystal Growth》2010,312(15):2273-2278
Epitaxial thin films of TmFeCuO4 with a two-dimensional triangular lattice structure were successfully grown on yttria-stabilized-zirconia substrates by pulsed laser deposition and ex situ annealing in air. The films as-deposited below 500 °C showed no TmFeCuO4 phase and the subsequent annealing resulted in the decomposition of film components. On the other hand, as-grown films deposited at 800 °C showed an amorphous nature. Thermal annealing converted the amorphous films into highly (0 0 1)-oriented epitaxial films. The results of scanning electron microscopic analysis suggest that the crystal growth process during thermal annealing is dominated by the regrowth of non-uniformly shaped islands to the distinct uniform islands of hexagonal base. 相似文献
119.
Issei Doi Genichiro Tsuji Kyoko Kawakami Dr. Osamu Nakagawa Dr. Yosuke Taniguchi Prof. Shigeki Sasaki 《Chemistry (Weinheim an der Bergstrasse, Germany)》2010,16(39):11993-11999
DNA containing alternating purine and pyrimidine repeats has the potential to adopt the Z‐DNA structure, one of the well‐studied structures besides A‐ and B‐DNA. Despite a number of molecular models that have been proposed to explain the mechanism for B→Z transition, there is continued discussion on the mechanism and physiological role of this transition. In this study, we have found that the bis(2‐naphthyl)‐maleimide–spermine conjugate ( 3 c ) exhibits a remarkable ability to cause the B→Z transition of d(CGCGCG)2 at low salt concentrations. Using isothermal titration calorimetry (ITC) we show that the B→Z transition induced by 3 c is both enthalpically and entropically favorable. The ligand might effect the dehydration of B‐DNA, which leads to the B→Z transition. Interestingly, an intermediate CD between the B and Z forms was observed in the pH‐dependent transition in the presence of the ligand. The unique structure and characteristics of the ligand designed in this investigation will be useful for the study of Z‐DNA. 相似文献
120.
Kenichi Murata Kazuki Kajiya Megumi Nukaga Yosuke Suga Toshiyuki Watanabe Nobuhumi Nakamura Hiroyuki Ohno 《Electroanalysis》2010,22(2):185-190
A simple method for constructing gold nanoparticle‐modified electrodes with three‐dimensional nanostructures is demonstrated. The electrodes were prepared by casting citrate‐reduced AuNPs onto polycrystalline gold electrodes. The resultant electrodes had a large surface area‐to‐volume ratio, adequate for high protein loading and conferring high stability. The gold nanoparticle electrodes were covered with a self‐assembled monolayer of 11‐mercaptoundecanoic acid for electrostatic immobilization of cytochrome c (cyt c). At the electrode, direct, reversible electron transfer from cyt c was observed with remarkable stability. Moreover, an extremely high surface coverage of electrochemically active cyt c, 167 fully packed monolayers, was obtained through use of the electrode. 相似文献