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61.
As a global health problem, liver fibrosis still does not have approved treatment. It was proved that N-(3,4,5-trichlorophenyl)-2(3-nitrobenzenesulfonamide) benzamide (IMB16-4) has anti-hepatic fibrosis activity. However, IMB16-4 displays poor water solubility and poor bioavailability. We are devoted to developing biodegraded liposome-coated polymeric nanoparticles (LNPs) as IMB16-4 delivery systems for improving aqueous solubility, cellular uptake, and anti-fibrotic effects. The physical states of IMB16-4−LNPs were analyzed using a transmission electron microscope (TEM), high-performance liquid chromatography (HPLC), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and differential scanning calorimeter (DSC). The results show that IMB16-4−LNPs increased the drug loading compared to liposomes and enhanced cellular uptake behavior compared with IMB16-4−NPs. In addition, IMB16-4−LNPs could repress the expression of hepatic fibrogenesis-associated proteins, indicating that IMB16-4−LNPs exhibited evident anti-fibrotic effects. 相似文献
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Rui Zhang Leng Ni Xiao Di Baitao Ma Shuai Niu Zhihua Rong Changwei Liu 《Molecules (Basel, Switzerland)》2021,26(4)
Carotid artery stenosis (CAS) is an atherosclerotic disease characterized by a narrowing of the artery lumen and a high risk of ischemic stroke. Risk factors of atherosclerosis, including smoking, hypertension, hyperglycemia, hyperlipidemia, aging, and disrupted circadian rhythm, may potentiate atherosclerosis in the carotid artery and further reduce the arterial lumen. Ischemic stroke due to severe CAS and cerebral ischemic/reperfusion (I/R) injury after the revascularization of CAS also adversely affect clinical outcomes. Melatonin is a pluripotent agent with potent anti-inflammatory, anti-oxidative, and neuroprotective properties. Although there is a shortage of direct clinical evidence demonstrating the benefits of melatonin in CAS patients, previous studies have shown that melatonin may be beneficial for patients with CAS in terms of reducing endothelial damage, stabilizing arterial plaque, mitigating the harm from CAS-related ischemic stroke and cerebral I/R injury, and alleviating the adverse effects of the related risk factors. Additional pre-clinical and clinical are required to confirm this speculation. 相似文献
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针对蛇形圆波导变换器尺寸大和带宽窄的不足,提出了变周期蛇形圆波导模式变换器,以实现TE01到TE11模式的高效率转换。根据耦合波方程,编制了优化计算程序,对工作于30.5 GHz、半径为16 mm的变周期以及传统蛇形变换器几何结构分别进行了优化计算,得到了可实现最高模式变换效率的几何参量。计算结果表明:传统结构变换器最优长度长达1 056.97 mm,转换效率98.1%,90%以上转换带宽也仅为3.3%;变周期变换器最优长度为769.53 mm,转换效率为99.3%,90%以上转换带宽为5.9%。变周期结构相对于传统结构的模式变换器具有尺寸小和带宽宽的明显优势。测试表明所提出的模式变换器具有良好的模式变换性能。 相似文献
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A Phosphorescent Platinum(II) Bipyridyl Supramolecular Polymer Based on Quadruple Hydrogen Bonds 下载免费PDF全文
Fang‐Wei Liu Dr. Li‐Ya Niu Prof. Yong Chen Prof. Vaidhyanathan Ramamurthy Prof. Li‐Zhu Wu Prof. Chen‐Ho Tung Prof. Yu‐Zhe Chen Prof. Qing‐Zheng Yang 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(50):18132-18139
A platinum(II) bipyridyl complex bearing bis‐ureidopyrimidinone (Pt‐bisUPy) has been designed and its self‐assembling behavior has been thoroughly investigated by 1H NMR, DOSY NMR, Ubbelohde viscometry analysis, UV/Vis, and emission spectroscopies. Pt‐bisUPy underwent concentration‐dependent ring‐chain polymerization in apolar solvents. Hydrogen‐bonding interactions play an important role during the formation of the supramolecular polymers. Hydrogen‐bonded supramolecular polymers were transformed to nanoparticles in water through the miniemulsion method. These nanoparticles showed strong π–π excimeric emission. Metal‐metal‐to‐ligand charge transfer (MMLCT) from Pt–Pt interactions was not significant in the emission spectrum. The phosphorescence of the nanoparticle persisted even under aerobic conditions. The triplet state of these phosphorescent nanomaterials were long‐lived and possessed moderate emission quantum yields. Furthermore, the low toxicity of these materials promises a place for them in in vitro and in vivo bioimaging. 相似文献
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