Transdermal patches of meloxicam (MX) and lornoxicam (LX) were aimed to be prepared in order to overcome their side effects by oral application. The strategy was formulation of optimized films to prepare transdermal patches by determination of physical properties and investigation of drug-excipient compatibility. As the next step, in vitro drug release, assesment of anti-inflammatory effect on Wistar Albino rats, ex vivo skin penetration and investigation of factors on drug release from transdermal patches were studied. Hydroxypropyl methylcellulose (HPMC) was concluded to be suitable polymer for formulation of MX and LX transdermal films indicating pharmaceutical quality required. MX and LX transdermal patches gave satisfactory results regarding to the edema inhibition in the assessment of anti-inflammatory effect. MX was found out to be more effective compared to LX on relieving of edema and swelling. These results were supported by data obtained from ex vivo penetration experiments of drug through rat skin. Indicative parameters like log P, molecular weight and solubility constraint on penetration rate of drugs also indicated good skin penetration. Transdermal patches of MX and LX can be suggested to be used especially for the immediate treatment of inflammated area since it displays anti-inflammatory effect, soon. 相似文献
In the present paper we prove some fixed point theorems for ?iri?-type strong almost contractions on partial metric spaces. We also give an illustrative example. 相似文献
The discrepancies between the published QM/MM studies (Sch?neboom, J. C.; Cohen, S.; Lin, H.; Shaik, S.; Thiel, W. J. Am. Chem. Soc. 2004, 126, 4017; Guallar, V.; Friesner, R. A. J. Am. Chem. Soc. 2004, 126, 8501) on H-abstraction of camphor in P450cam have largely been resolved. The crystallographic water molecule 903 situated near the oxo atom of Compound I acts as a catalyst for H-abstraction, lowering the barrier by about 4 kcal/mol. Spin density at the A-propionate side chain of heme can occur in the case of incomplete screening but has no major effect on the computed barrier. 相似文献
The solute–solvent interactions of some phenol derivatives were investigated potentiometrically in 0–60 % (v/v) ethanol–water mixtures. The acidity constants values were correlated with either macroscopic parameters such as molar fraction, permittivity and the solvating ability or microscopic parameters, such as the Kamlet–Taft solvatochromic parameters. Moreover, it is demonstrated that the pKa values in any ethanol–water mixtures are linearly related to the pKa values of the phenols in pure water. The slope and intercept parameters of the linear correlations are related with the mole fraction of ethanol. These equations permit accurate calculation of the pKa values of the studied phenols at any ethanol–water composition. 相似文献
Photoactivated cross-linking of peptides to proteins is a useful strategy for identifying enzyme-substrate and protein-protein interactions in cell lysates as demonstrated by studies on the human hypoxia inducible factor system. 相似文献
This paper presents the dynamic feedforward control synthesis for linear parameter varying (LPV) systems. It is assumed that all system matrices are dependent on varying parameters, which are measurable with sensor or observable. The parameters have bounded variation rates. Parameter-dependent Lyapunov function is used for the feedforward control synthesis such that the robust stability is assured for all varying parameters at the time of the operation. The method is formulated in terms of linear matrix inequalities for LPV feedforward controller that guarantees the stability of the transfer matrix having \(L_{2}\)-gain. This compensator is designed by adding on the feedback controller in two degrees of freedom control configuration. This controller can be used for the disturbance attenuation or decreasing the tracking error. The numerical examples and simulations are given to provide the applicability of the proposed solution. 相似文献
In this paper, the investigation of the asymptotical stability of linear neutral systems with time-varying delay has been presented. In order to achieve the desired results, the integral inequality approach was used to express relationships between terms of Newton-Leibniz formula technique and was constructed an appropriate Lyapunov-Krasovskii functional. By improving a delay decay approach, the stability criteria for the zero solution of system were formulated as linear matrix inequalities (LMIs) which can be easily solved. Two numerical examples have been given to show the applicability of established assumptions and the effectiveness of proposed method by MATLAB-Simulink. 相似文献
The natural radioactivity levels and some radiological parameters of Turkish Portland cements (PC) originated in various regions were determined in this study. The activity concentration of cement samples for 226Ra, 232Th, and 40K were measured using a gamma-ray spectrometer with high purity germanium radiation detector. The PC samples had activity concentrations of 33.0, 16.7, and 239.5 Bq kg−1 for 226Ra, 232Th, and 40K, respectively. The mean value of radium equivalent value (Raeq) was found to be 75.4 Bq kg−1. The radium equivalent values in the cement samples were lower than the acceptable level of 370 Bq kg−1. The calculated radiological parameters were found to be below the acceptance levels.