Photoaffinity Probe Candidates for Gamma-aminobutyric Acid （GABAA）-Gated Chloride Channel

New photoaffinity ligand candidates were synthesized based on 5-t-buty1-2-(4-(substituted-ethyny1)phenyl)-1, 3-dithiane for the noncompetitive blocker site on the gammaaminobutyric acid-gated chloride channel. Their half-maximal inhibition concentrations ranged from 4 to 32 nmol/L as measured by 4‘-ethyny1-4-n-[2,3-3^H2]-propylbicycloorthobenzoate (3^H EBOB) assay.     

Measured local heat transport in turbulent Rayleigh-Bénard convection

Local convective heat flux in turbulent thermal convection is obtained from simultaneous velocity and temperature measurements in an aspect-ratio-one convection cell filled with water. It is found that fluctuations of the vertical heat flux are highly intermittent and are determined primarily by the thermal plumes in the system. The experiment reveals a unique mechanism for the heat transport in turbulent convection.     

The post-polyketide synthase modification steps in the biosynthesis of the antitumor agent ansamitocin by Actinosynnema pretiosum

The functions of six genes in the ansamitocin biosynthetic gene cluster of Actinosynnema pretiosum have been investigated by gene inactivation and chemical analysis of the mutants. They encode a halogenase (asm12), a carbamoyltransferase (asm21), a 20-O-methyltransferase (asm7), a 3-O-acyltransferase (asm19), an epoxidase (asm11), and an N-methyltransferase (asm10), respectively, and are responsible for the six post-PKS modification steps in ansamitocin formation. Several of the enzymes have relaxed substrate specificities, resulting in multiple parallel pathways in a metabolic grid, albeit with a preferred sequence of reactions as listed above.     

Quantitative enantiomeric analysis of chlorcyclizine,hydroxyzine, and meclizine by capillary electrophoresis

A simple capillary zone electrophoresis method was developed for the quantitative enantiomeric analysis of piperazine antihistamines with teratogenic suspicion in animals. Enantioseparation of chlorcyclizine, hydroxyzine, and meclizine was performed in glycine buffer (0.6 mol L^-1; pH 3.00) with sulfated -cyclodextrin (5 mg mL^-1) as a chiral selector; and the separated drugs were monitored by ultra-violet detector. The lower quantitation of the individual enantiomer is attainable at 10 µmol L^-1, using an achiral piperazine drug (cyclizine) as internal standard. The method is simple and rapid with a short run time (<5 min) for the analysis of chlorcyclizine, hydroxyzine or meclizine enantiomers.     

A Note on the KAM Theorem for Symplectic Mappings

The mapping version of Pöschel's theory on differentiable foliation structures of invariant tori is presented and the relevant estimates explicitly in terms of the diophantine constant and the nondegeneracy parameters of frequency maps are given. As a direct application of the main result, a generalization of Moser's small twist theorem to high dimensions is given.     

基于元胞传输模型的可变信息标志选址问题研究

随着智能交通技术的发展，可变信息标志(VMS)被广泛应用于动态交通管理中.元胞传输模型(CTM)可以较好地模拟交通流激波、排队形成与消散等交通流动力学特性.应用CTM对VMS选址问题进行了研究.数值模拟结果表明，合适的VMS位置可以减少系统内所有车辆的行驶时间.还分析了路径选择概率变化与VMS位置之间的关系.在一定范围内，交通事故越严重，VMS应设置在距离事故地点越远的地方. 关键词： 可变信息标志 选址问题 元胞传输模型 数值模拟     

利用偏振控制器连续调节光纤环镜的反射率

研究了一种新型光纤环镜(FLM)的原理与特性，这种FLM由在普通光纤环镜中插入光纤型偏振控制器(PC)构成.通过等效光路分析建立了该FLM的理论模型，并对其反射特性进行了数值模拟.研究表明，通过改变PC的状态，即改变其双折射效应的快轴取向或强度，可连续调节FLM的反射率，反射率谱具有宽带特性，主要受光纤耦合器工作带宽的影响.此外，对FLM的反射特性还进行了实验研究.实验结果也证实，通过调节PC状态，FLM反射率可在其最大和最小值之间连续调节，实验测得FLM最大和最小反射率分别可达93%和2%.根据PC双折 关键词： 光纤环镜 偏振控制器 光纤耦合器 反射率     

在玻璃转变温度及其以上温区聚苯乙烯/聚氧化乙烯共混物的动力学弛豫行为

用熔融共混法制备了不同组分的聚苯乙烯(PS)与聚氧化乙烯(PEO)共混物(PS/PEO).在玻璃转变温度T_g及其以上温区,利用相对能量耗散技术研究了该共混物的动力学行为.结果发现,在能量耗散-温度曲线上出现了两个弛豫型的耗散峰(α峰和α′峰).分析表明,α峰是与PS玻璃转变有关的特征耗散峰; α′峰则对应于一种“液-液转变”.两者的弛豫时间τ都不满足Arrhenius关系.此外,还研究了组分对这两个弛豫型耗散峰的影响,并给予了定性的解释. 关键词： 相对能量耗散 玻璃转变 力学弛豫     

立方结构Fe基磁性材料弹性系数第一性原理计算

通过赝势平面波法(CASTEP)及全电势线性缀加平面波法(FLAPW)，以bcc-Fe为对象，研究第一性原理计算立方结构Fe基磁性材料弹性系数的方法，分析影响计算立方结构Fe基磁性材料弹性系数准确度的各项因素. 结果表明，在第一性原理弹性系数计算中，晶格常数是决定弹性系数计算准确度的关键因素；势函数的选择也会影响计算准确度. 使用全电势基矢的FLAPW法可以得到更为精准的弹性系数计算结果. 计算得到bcc-Fe的弹性系数C₁₁，C₁₂，C₄₄分别为246 GPa，121 GPa，113 GPa，与实验值基本一致. 利用本方法，计算了新型Fe-Ga磁致伸缩材料的弹性系数C₁₁，C₁₂，C₄₄分别为207 GPa，166 GPa及108 GPa. 关键词： 弹性系数 磁致伸缩材料 赝势平面波法 全电势线性缀加平面波法     

“Positive” and “negative” electric-pulse-induced reversible resistance switching effect in Pr<Subscript>0.7</Subscript>Ca<Subscript>0.3</Subscript>MnO<Subscript>3</Subscript> films

“Negative” electric-pulse-induced reversible resistance (EPIR) switching phenomenon was found in In/PCMO/Pt sandwich, in which the high resistance can be written with positive voltage pulses, and the low resistance can be reset using negative voltage pulses (the positive voltage direction is defined as going from the top electrode to the bottom electrode). This is just the opposite from the “positive” EPIR effect in Ag/PCMO/Pt sandwich, in which the high resistance can be written only with negative voltage pulses, and the low resistance can be reset using positive voltage pulses. The I–V hysteresis curves of In/PCMO/Pt and Ag/PCMO/Pt sandwiches also show opposite directions, i.e., counterclockwise and clockwise under a negative voltage region for indium and Ag electrode systems, respectively. C–V characteristics show that the barrier does not exist in Ag/PCMO/Pt sandwich, while In/PCMO/Pt sandwich exhibits an obvious Schottky-like barrier. We suggest that in the negative EPIR behavior in In/PCMO/Pt structure, the resistance states are mainly controlled changing the Schottky-like barrier at the interface with the weak effect of carrier trapping process, while the positive EPIR behavior in Ag/PCMO/Pt sandwich mainly depends on the carrier trapping process at the interface. PACS 72.80.-r; 73.40.-C; 75.70.-i