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221.
煤焦在燃烧过程中孔隙结构变化的模拟 总被引:4,自引:1,他引:4
煤焦在燃烧过程中的物理特性,如比表面积和孔径分布会发生连续变化,直接测量煤焦在燃烧过程中的孔隙结构变化很困难,但可以通过合适的数学模型来观察,二维的圆柱孔模型已大量用来对煤焦气化与燃烧过程中表面积和孔隙结构的变化进行模拟,这个模型把孔隙分成两大部分--大孔与小孔,因为小孔构成比表面的绝大部分,所以在反应过程中比表面积的变化可以由单一小孔模型来拟合,本文采用了用Tseng和Edgar提出的孔模型对几 相似文献
222.
Jun Liu Kelton A. Schleyer Tyrel L. Bryan Changjian Xie Gustavo Seabra Yongmei Xu Arjun Kafle Chao Cui Ying Wang Kunlun Yin Benjamin Fetrow Paul K. P. Henderson Peter Z. Fatland Jian Liu Chenglong Li Hua Guo Lina Cui 《Chemical science》2021,12(1):239
Heparanase (HPA) is a critical enzyme involved in the remodeling of the extracellular matrix (ECM), and its elevated expression has been linked with diseases such as various types of cancer and inflammation. The detection of heparanase enzymatic activity holds tremendous value in the study of the cellular microenvironment, and search of molecular therapeutics targeting heparanase, however, no structurally defined probes are available for the detection of heparanase activity. Here we present the development of the first ultrasensitive fluorogenic small-molecule probe for heparanase enzymatic activity via tuning the electronic effect of the substrate. The probe exhibits a 756-fold fluorescence turn-on response in the presence of human heparanase, allowing one-step detection of heparanase activity in real-time with a picomolar detection limit. The high sensitivity and robustness of the probe are exemplified in a high-throughput screening assay for heparanase inhibitors.Heparanase, a critical enzyme involved in the remodeling of the extracellular matrix, activates a disaccharide probe HADP to give a strong fluorescence signal. 相似文献
223.
羰基铑催化剂由于其加氢性能较弱,在羰基化反应的研究中,通常仅作为烯烃氢甲酰化制醛的催化剂。产物中得不到醇。本文则报道了以Rh_2(AcO)_4和Rh_6(CO)_16为催化剂,在一个反应器内进行烯烃氢甲酰化,加氢制醇的研究。系统考察了Rh/Pbu_3/EtOH催化体系受各种反应条件的影响。在最佳反应条件下,烯烃转化率达100%。对醇选择性亦在99.5%以上,正异构比在2以上.为烯烃一步制醇建立了铑系催化新体系。文中并利用红外光谱测定了反应过程的催化剂物种.实验证明,由烯烃一步制醇是由烯烃首先进行氢甲酰化反应,然后由生成的醛进一步加氢成醇的一个串联反应过程。前一步骤反应速度较快,2h内可使95%以上的烯烃转化为醛,后面由醛加氢成醇则进行缓慢,在100—120℃下,至少22h,才能使醛全部转化为醇。 相似文献
224.
本文以二茂镍为母体化合物,以氧化铝和氧化硅为担体制备了担载镍催化剂。为了表征其结构特点,对这些催化剂热分解处理前后的样品在日本筑波高能物理研究所(Photon-Factory)的同步辐射加速器BL—10B EXAFS实验站进行了外延x-光精细结构谱测定(透射法)。以单散射球面波理论对实验结果进行了多参数拟合,同时对母体化合物也进行了平行测定和拟合,以验证数据及拟合方法的可靠性。研究结果表明,母体化合物的EXAFS结果与文献XRD相一致;母体化合物与担体表面发生了强烈的化学作用;镍组分在催化剂表面高度分散,氧化铝与Ni(C_5H_5)_2有更强的相互作用形成。Ni[(O)_s]_n(n≈4),近一半的镍原子周围有0.30 nm处的镍原子散射;氧化硅上除Ni[(CO)_s]_n(n≈3)外,在0.30 nm处有配位数为2的非成键Ni原子。 相似文献
225.
Liping Zhao Shengfu Ji Fengxiang Yin Zexiang Lu Hui Liu Chengyue Li 《天然气化学杂志》2006,15(4):287-296
A series of CoxMgxO/Al2O3/FeCrAl catalysts (x=0-1) were prepared. The structures of the catalysts were characterized using XRD, SEM, and TPR analyses. The catalytic activity of the catalysts for methane combustion was evaluated in a continuous flow microreactor. The results indicated that the active washcoats adhered well on the FeCrAl foils. The phases in the catalysts were Co--xMgxO solid solutions, α-Al2O3, and γ-Al2O3. The surface particle size of the catalysts varied with variations in the molar ratios of Co to Mg. The Co component of the Co1_xMgxO/Al2O3/FeCrAl catalysts played an important role in the catalytic activity for methane combustion. In the Co1-xMgxO/AluO3/FeCrAl series catalyst (x=0.2-0.8), the catalytic activity in terms of x was in the order of 0.5〉0.2〉0.8 under the experimental conditions. The presence of Mg in these catalysts could promote the thermal stability to a large extent. There were strong interactions between the Co1-xMgxO oxides and the AluO3/FeCrAl supports. 相似文献
226.
High performance liquid chromatography (HPLC) and electrospray ionization mass spectrometry (ESI-MS) have been utilized to analyze the synthesized 2-(2-arylaminomethylphenoxy)pyrimidine derivatives, which are a new kind of environmentally benign herbicides and have passed the temporary pesticide registration. The identification of main product and impurities has been achieved according to the UV and mass spectra. Moreover, one impurity, introduced by the raw material in the last step of the synthetic route, was identified by GC-MS analysis. It can be concluded that the combination of chromatography and mass spectrometry, including LC-MS and GC-MS, provided a vital tool of the pesticide science. 相似文献
227.
Yanfang Wu Yin Yao Soshan Cheong Richard D. Tilley J. Justin Gooding 《Chemical science》2020,11(46):12570
Disease diagnosis at earlier stages requires the development of ultrasensitive biosensors for detecting low-abundance biomarkers in complex biological fluids within a reasonable time frame. Here, we demonstrate the development of an ultrasensitive nanopore blockade biosensor that can rapidly diagnose a model protein biomarker, prostate-specific antigen (PSA) with high selectivity. The solid-state nanopores have gold located only along the length of the nanopore whilst the rest of the membrane is silicon nitride. The orthogonal use of materials allows nanopore arrays with a different surface chemistry inside the nanopore relative to the rest of the membrane to be fabricated. The importance of this differential surface chemistry is it can improve the detection limit of nanopore blockade sensors in quantitative analysis. Based on such functionalized nanopore devices, nanopore blockade sensors lower the limit of detection by an order of magnitude and enable ultrasensitive detection of PSA as low as 80 aM. The findings from this study open new opportunities for nanopore sensors in further developments including optical detection and ultralow detection limit biosensing at complex biological fluids.Selective detection of attomolar proteins was achieved using gold lined nanopores in a nanopore blockade sensor. 相似文献
228.
Venkateshrao S Yin J Jarzecki AA Schultz PG Spiro TG 《Journal of the American Chemical Society》2004,126(50):16361-16367
Resonance Raman (RR) spectra are reported for mesoporphyrin IX bound to the Fab fragment of the ferrochelatase antibody 7G12. Binding induces activation of a Raman band at 680 cm(-1), which is assigned to an out-of-plane porphyrin vibration, gamma15. This is exactly the predicted effect of distorting mesoporphyrin to the geometry of N-methylmesoporphyrin IX, the 7G12 hapten, based on DFT/CIS modeling of the RR spectrum. The modeling also shows that the pyrrole ring that is tilted out of the porphyrin plane bears a nitrogen lone pair, which is therefore available for coordination by an incoming metal ion. The 680 cm(-1) band intensity is approximately 3 times higher for the affinity-matured antibody than for the germline precursor antibody, while intermediate values are found for variants in which germline residues are mutated to mature residues or vice versa. Thus, RR spectroscopy reveals an evolution from weak substrate distortion in the germline antibody to strong substrate distortion in the affinity-matured antibody, and supports the view that catalysis involves a substrate strain mechanism. 相似文献
229.
Synthesis of lipid A derivatives and their interactions with polymyxin B and polymyxin B nonapeptide 总被引:5,自引:0,他引:5
Yin N Marshall RL Matheson S Savage PB 《Journal of the American Chemical Society》2003,125(9):2426-2435
Lipid A is the causative agent of Gram-negative sepsis, a leading cause of mortality among hospitalized patients. Compounds that bind lipid A can limit its detrimental effects. Polymyxin B, a cationic peptide antibiotic, is one of the simplest molecules capable of selectively binding lipid A and may serve as a model for further development of lipid A binding agents. However, association of polymyxin B with lipid A is not fully understood, primarily due to the low solubility of lipid A in water and inhomogeneity of lipid A preparations. To better understand lipid A-polymyxin B interaction, pure lipid A derivatives were prepared with incrementally varied lipid chain lengths. These compounds proved to be more soluble in water than lipid A, with higher aggregation concentrations. Isothermal titration calorimetric studies of these lipid A derivatives with polymyxin B and polymyxin B nonapeptide indicate that binding stoichiometries (peptide to lipid A derivative) are less than 1 and that affinities of these binding partners correlate with the aggregation states of the lipid A derivatives. These studies also suggest that cooperative ionic interactions dominate association of polymyxin B and polymyxin B nonapeptide with lipid A. 相似文献
230.
PVA/PVP共混物的聚集态结构 总被引:2,自引:0,他引:2
热处理前后不同组份比二元共混物聚乙烯醇(PVA)和聚乙烯吡咯烷酮(PVP)的聚集态结构研究表明,热处理可明显提高共混物的结晶性。热处理前样品仅观察到(101)晶面衍射,热处理后可观察到4个以上衍射晶面。结晶度和微晶大小随共混物中PVP含量增加而降低。第二类晶格畸变则随PVP含量增加而增大。 相似文献