全文获取类型
收费全文 | 734篇 |
免费 | 12篇 |
国内免费 | 2篇 |
专业分类
化学 | 392篇 |
力学 | 16篇 |
数学 | 220篇 |
物理学 | 120篇 |
出版年
2020年 | 6篇 |
2017年 | 7篇 |
2016年 | 13篇 |
2015年 | 14篇 |
2014年 | 10篇 |
2013年 | 27篇 |
2012年 | 39篇 |
2011年 | 23篇 |
2010年 | 25篇 |
2009年 | 22篇 |
2008年 | 18篇 |
2007年 | 23篇 |
2006年 | 19篇 |
2005年 | 26篇 |
2004年 | 25篇 |
2003年 | 16篇 |
2002年 | 9篇 |
2001年 | 5篇 |
2000年 | 12篇 |
1999年 | 10篇 |
1998年 | 13篇 |
1997年 | 7篇 |
1996年 | 11篇 |
1995年 | 14篇 |
1994年 | 19篇 |
1993年 | 15篇 |
1992年 | 20篇 |
1991年 | 14篇 |
1990年 | 13篇 |
1989年 | 12篇 |
1988年 | 16篇 |
1987年 | 15篇 |
1986年 | 12篇 |
1985年 | 11篇 |
1984年 | 16篇 |
1983年 | 10篇 |
1982年 | 13篇 |
1981年 | 12篇 |
1980年 | 7篇 |
1979年 | 21篇 |
1978年 | 9篇 |
1977年 | 9篇 |
1976年 | 7篇 |
1975年 | 10篇 |
1974年 | 5篇 |
1971年 | 6篇 |
1969年 | 7篇 |
1966年 | 5篇 |
1965年 | 8篇 |
1960年 | 6篇 |
排序方式: 共有748条查询结果,搜索用时 31 毫秒
741.
David Falck Nils Helge Schebb Setyo Prihatiningtyas Jiawen Zhang Ferry Heus Christophe Morisseau Jeroen Kool Bruce D. Hammock Wilfried M. A. Niessen 《Chromatographia》2013,76(1-2):13-21
In this study, an end-point-based fluorescence assay for soluble epoxide hydrolase (sEH) was transformed into an on-line continuous-flow format. The on-line biochemical detection system (BCD) was coupled on-line to liquid chromatography (LC) to allow mixture analysis. The on-line BCD was based on a flow system wherein sEH activity was detected by competition of analytes with the substrate hydrolysis. The reaction product was measured by fluorescence detection. In parallel to the BCD data, UV and MS data were obtained through post-column splitting of the LC effluent. The buffer system and reagent concentrations were optimized resulting in a stable on-line BCD with a good assay window and good sensitivity (S/N > 60). The potency of known sEH inhibitors (sEHis) obtained by LC–BCD correlates well with published values. The LC–BCD system was applied to test how oxidative microsomal metabolism affects the potency of three sEHis. After incubation with pig liver microsomes, several metabolites of sEHis were characterized by MS, while their individual potencies were measured by BCD. For all compounds tested, active metabolites were observed. The developed method allows for the first time the detection of sEHis in mixtures providing new opportunities in the development of drug candidates. 相似文献
742.
de Vlieger JS Giezen MJ Falck D Tump C van Heuveln F Giera M Kool J Lingeman H Wieling J Honing M Irth H Niessen WM 《Analytica chimica acta》2011,698(1-2):69-76
In this paper we describe the hyphenation of high temperature liquid chromatography with ICP-MS and ESI-MS for the characterization of halogen containing drug metabolites. The use of temperature gradients up to 200°C enabled the separation of metabolites with low organic modifier content. This specific property allowed the use of detection methods that suffer from (significant) changes in analyte response factors as a function of the organic modifier content such as ICP-MS. Metabolites of two kinase inhibitors (SB-203580-Iodo and MAPK inhibitor VIII) produced by bacterial cytochrome P450 BM3 mutants and human liver microsomes were identified based on high resolution MS(n) data. Quantification was done using their normalized and elemental specific response in the ICP-MS. The importance of these kinds of quantification strategies is stressed by the observation that the difference of the position of one oxygen atom in a structure can greatly affect its response in ESI-MS and UV detection. 相似文献
743.
An application of the finite fracture mechanics concept to open-hole plates subject to combined tensile and bending loading is presented. In finite fracture mechanics, the simultaneous satisfaction of both, a stress and an energy criterion, is enforced as a condition for crack initiation. Efficient modeling and closed-form expressions for the dependence of the stress and energy quantities on governing structural and material parameters allow for a comprehensive numerical analysis of the onset of asymmetric crack patterns. The obtained failure load predictions are found to agree well with a cohesive zone model and experimental data from literature. (© 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
744.
745.
746.
747.
748.
Wilfried Hatke Horst-Tore Land Hans-Werner Schmidt Walter Heitz 《Macromolecular rapid communications》1991,12(4):235-243
The substitution of poly(p-phenylene terephthalate) and poly(p-phenylene terephthalamide) with phenyl and biphenylyl substituents (4-biphenylyl and 2-biphenylyl) in the terephthalic acid unit lowers the melting temperatures and crystallization tendency and increases the solubility. The melting temperatures of the polyesters are in the range of 285–350°C. Melting of the polyamides occurs between 440–490°C. The polyamides begin to decompose in the same temperature range. In polyesters as well as in polyamides the 2-biphenylyl substituent was found to be more effective in decreasing the crystallinity, lowering the melt transition temperatures and increasing the solubility. 相似文献