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61.
62.
近江牡蛎受精细胞学研究 总被引:5,自引:0,他引:5
用醋酸──地衣红染色的方法对近江牡蛎人工授精的卵子减数分裂和受精过程进行了详细的细胞学观察.精子入卵前,卵子处于第一次减数分裂的前期(胚泡期),精子入卵后,胚泡消失,然后进行两次减数分裂,在海水温度为28.8℃的情况下,授精后33min和45min,绝大部分受精卵已排出第一极体和第二极体,雄原核可在第一极体排出后及第二极体排出前任何时期内形成,雌雄原核以联合的方式将两组染色体合并,授精后1h,大部分卵子完成第一次卵裂.在25℃和26℃授精的情况下,观察到了较多的多精入卵的现象.卵子发育的非同步性现象非常明显. 相似文献
63.
Mengxing Cui Ryuichi Murase Yongbing Shen Tetsu Sato Shohei Koyama Kaiji Uchida Tappei Tanabe Shinya Takaishi Masahiro Yamashita Hiroaki Iguchi 《Chemical science》2022,13(17):4902
Electrical conduction among metallocycles has been unexplored because of the difficulty in creating electronic transport pathways. In this work, we present an electrocrystallization strategy for synthesizing an intrinsically electron-conductive metallocycle, [Ni6(NDI-Hpz)6(dma)12(NO3)6]·5DMA·nH2O (PMC-hexagon) (NDI-Hpz = N,N′-di(1H-pyrazol-4-yl)-1,4,5,8-naphthalenetetracarboxdiimide). The hexagonal metallocycle units are assembled into a densely packed ABCABC… sequence (like the fcc geometry) to construct one-dimensional (1D) helical π-stacked columns and 1D pore channels, which were maintained under the liberation of H2O molecules. The NDI cores were partially reduced to form radicals as charge carriers, resulting in a room-temperature conductivity of (1.2–2.1) × 10−4 S cm−1 (pressed pellet), which is superior to that of most NDI-based conductors including metal–organic frameworks and organic crystals. These findings open up the use of metallocycles as building blocks for fabricating conductive porous molecular materials.Intrinsically electron-conductive metallocycle was synthesized. π-Radicals play a key role in constructing π-stacked columns among molecular hexagons and achieving high electrical conductivity over 10−4 S cm−1 in polycrystalline pellet. 相似文献
64.
采用基于平面波基组的Vienna Ab-initio Simulations Package (VASP)程序研究了SO_2和NO_2在γ-Al_2O_3(110)表面和羟基化γ-Al_2O_3(110)表面的吸附,获得了SO_2和NO_2吸附的不同构型和结构参数.对吸附能,电荷转移,差分电荷密度和投影态密度等进行分析和讨论.对比发现,在γ-Al_2O_3(110)表面SO_2的吸附能力强于NO_2.SO_2或NO_2在非羟基化γ-Al_2O_3(110)表面吸附时O原子的2p轨道和Al原子的3s3p轨道作用形成O-Al键,且SO_2吸附时键结强度高于NO_2.NO_2吸附时费米能级以下有部分反键态,削弱了与γ-Al_2O_3(110)表面相互作用.在羟基化γ-Al_2O_3(110)表面SO_2或NO_2的吸附能力会低于非羟基化表面,但是SO_2的吸附能力依旧强于NO_2.计算结果说明SO_2与γ-Al_2O_3(110)表面的相互作用强于NO_2.以上研究,将有助于理解SO_2和NO_2在γ-Al_2O_3的反应性,为进一步研究它们的非均相转化和在灰霾形成中的促进作用奠定基础. 相似文献
65.
Shengnan Xie Li Li Baihe Zhan Xue Shen Xuming Deng Wenxi Tan Tianqi Fang 《Molecules (Basel, Switzerland)》2022,27(9)
The emergence of the plasmid-mediated colistin resistance gene mcr-1 has resulted in the loss of available treatments for certain severe infections. Here we identified a potential inhibitor of MCR-1 for the treatment of infections caused by MCR-1-positive drug-resistant bacteria, especially MCR-1-positive carbapenem-resistant Enterobacteriaceae (CRE). A checkerboard minimum inhibitory concentration (MIC) test, a killing curve test, a growth curve test, bacterial live/dead assays, scanning electron microscope (SEM) analysis, cytotoxicity tests, molecular dynamics simulation analysis, and animal studies were used to confirm the in vivo/in vitro synergistic effects of pogostone and colistin. The results showed that pogostone could restore the bactericidal activity of colistin against all tested MCR-1-positive bacterial strains or MCR-1 mutant–positive bacterial strains (FIC < 0.5). Pogostone does not inhibit the expression of MCR-1. Rather, it inhibits the binding of MCR-1 to substrates by binding to amino acids in the active region of MCR-1, thus inhibiting the biological activity of MCR-1 and its mutants (such as MCR-3). An in vivo mouse systemic infection model, pogostone in combination with colistin resulted in 80.0% (the survival rates after monotherapy with colistin or pogostone alone were 33.3% and 40.0%) survival at 72 h after infection of MCR-1-positve Escherichia coli (E. coli) ZJ487 (blaNDM-1-carrying), and pogostone in combination with colistin led to one or more order of magnitude decreases in the bacterial burdens in the liver, spleen and kidney compared with pogostone or colistin alone. Our results confirm that pogostone is a potential inhibitor of MCR-1 for use in combination with polymyxin for the treatment of severe infections caused by MCR-1-positive Enterobacteriaceae. 相似文献
66.
Feng Xia Yanrong Zhao Meijun Xing Zhenning Sun Yizhou Huang Jianghua Feng Guiping Shen 《Molecules (Basel, Switzerland)》2022,27(9)
The difference of nutrient composition between organic eggs and conventional eggs has always been a concern of people. In this study, 1H nuclear magnetic resonance (NMR) technique combined with multivariate statistical analyses was conducted to identify the metabolite different in egg yolk and egg white in order to reveal the nutritional components information between organic and conventional eggs. The results showed that the nutrient content and composition characteristics were different between organic and conventional eggs, among which the content of glucose, putrescine, amino acids and their derivatives were found higher in the organic eggs yolk, while phospholipids were demonstrated higher in conventional eggs yolk. Organic acid, alcohol, amine, choline and amino acids were higher in conventional eggs white, but glucose and lactate in organic egg were higher. Our study demonstrated that there are more nutritive components and higher nutritional value in organic eggs than conventional eggs, especially for the growth and development of infants and young children, and conventional eggs have more advantages in promoting lipid metabolism, preventing fatty liver, and reducing serum cholesterol. Eggs have important nutritional value to human body, and these two kinds of eggs can be selected according to the actual nutrient needs. 相似文献
67.
Shiou-Shiow Farn Yen-Buo Lai Kuo-Fong Hua Hsiang-Ping Chen Tzu-Yi Yu Sheng-Nan Lo Li-Hsin Shen Rong-Jiun Sheu Chung-Shan Yu 《Molecules (Basel, Switzerland)》2022,27(9)
A small fenbufen library comprising 18 compounds was prepared via Suzuki Miyara coupling. The five-step preparations deliver 9–17% biphenyl compounds in total yield. These fenbufen analogs exert insignificant activity against the IL-1 release as well as inhibiting cyclooxygenase 2 considerably. Both the para-amino and para-hydroxy mono substituents display the most substantial COX-2 inhibition, particularly the latter one showing a comparable activity as celecoxib. The most COX-2 selective and bioactive disubstituted compound encompasses one electron-withdrawing methyl and one electron-donating fluoro groups in one arene. COX-2 is selective but not COX-2 to bioactive compounds that contain both two electron-withdrawing groups; disubstituted analogs with both resonance-formable electron-donating dihydroxy groups display high COX-2 activity but inferior COX-2 selectivity. In silico simulation and modeling for three COX-2 active—p-fluoro, p-hydroxy and p-amino—fenbufens show a preferable docking to COX-2 than COX-1. The most stabilization by the p-hydroxy fenbufen with COX-2 predicted by theoretical simulation is consistent with its prominent COX-2 inhibition resulting from experiments. 相似文献
68.
Mn(Ⅱ),Co(Ⅱ)与HSA相互作用的荧光光谱研究 总被引:5,自引:0,他引:5
用荧光光谱法研究了生理pH和等离子点(pH=5.30)时Mn(Ⅱ)、Co(Ⅱ)与HSA的相互作用。根据Forste非辐射能量转移理论,得到了不同pH时Mn(Ⅱ)、Co(Ⅱ)在HSA中的第一强结合位置与Trp-214残基间的距离。这一结果远大于文献报道值,根据Mn(Ⅱ)、Co(Ⅱ)在HSA中的结合部位及HSA的畴结构对这一显著差异进行了讨论。 相似文献
69.
Shengkai Li Zhaotian Zhu Xinqi Cai Minghui Song Shen Wang Qing Hao Long Chen Zhuo Chen 《中国化学》2021,(6):1491-1497
Main observation and conclusion
Surface-enhanced Raman spectroscopy(SERS)-based bioanalytical technique involves the interaction of SERS-active substrate with c... 相似文献
70.
Jinkun Sun Yingjian Liu Jiayi Huang Jiatian Li Mengmeng Chen Xiaoyu Hu Yatao Liu Run Wang Yanan Shen Jingjing Li Xuecheng Chen Dong Qian Baigang An Zunfeng Liu 《Journal of Energy Chemistry》2021,(12):594-603
Increasing mechanical flexibility without sacrificing electrochemical performance of the electrode mate-rial is highly desired in the design of flexible electro... 相似文献