Pd-Catalyzed Ortho-Directed C-H Glycosylation of Arenes Using N-linked Bidentate Auxiliaries

A set of Pd-catalyzed ortho-directed C-H glycosylation reactions with glycosyl chloride donors using various N-linked bidentate auxiliaries has been developed f...     

精神发育迟滞儿童致病原因的初步调查

本文对杭州市三所特殊教育学校的110名精神发育迟滞儿童进行了初步调查,了解了导致他们智力发展迟滞的原因.我们把精神发育迟滞的原因分为出生前的、出生时的和出生后的三类.由于出生前的因素而导致精神发育迟滞的,占被调查总人数的51.89％;由于出生时的因素而导致精神发育迟滞的占被凋查总人数的14.15％;由于出生后的因素(?)而导致精神发育迟滞的占被调查总人数的27.36％;另外还有6.6％属原因不明的.除了对每一个儿童的主要致病原因作了归类统计外,还把造成精神发育迟滞的各种致病因素的频次进行了统计. 本文还讨论了判别精神发育迟滞儿童的指标问题、病原学问题以及早期教育的问题. 最后,在预防和矫治方面,提出了建议.对轻度精神发育迟滞的儿童,可采用特殊教育的方法,通过系统教育和适当训练,激发他们的潜能,使他们成为对社会有用的成员.     

电子背散衍射花样的数学特征

电子背散衍射(EBSD)花样揭示了材料的物相成分、晶体结构、晶粒取向、晶粒大小和晶界的信息。EBSD花样非常复杂,通常需要借助专门的计算软件才能解析。本文系统地研究了EBSD花样的数学特征,建立了任意晶体取向与EBSD花样之间的数理关系,推导了面心立方、体心立方和六方晶体的基本晶带轴的理论EBSD花样的数学特征,以及面心立方晶体的(001)<110>取向和(001)<100>取向的理论菊池(Kikuchi)花样特征。在实测EBSD花样的分析中与各晶系各点阵的基本晶带轴的理论EBSD花样特征比较,即通过图像特征对比,就可以直接确定实测EBSD花样所属的晶系、点阵和Kikuchi线交点对应的晶带轴[uvw],再由基本晶带轴的坐标计算出晶体取向,还能提供基本晶面信息,如原子密排晶面在样品中的空间分布,这有利于晶体的变形或生长机理研究。EBSD为单晶芯片质量检验提供了新方法。     

Thermal decomposition and kinetics studies on poly(BDFAO/THF), poly(DFAMO/THF), and poly(BDFAO/DFAMO/THF)

The thermal behavior of kaolinite–urea intercalation complex was investigated by thermogravimetry–differential scanning calorimetry (TG–DSC), X-ray diffraction (XRD), and fourier transform infrared spectroscopy (FTIR). In addition, the interaction mode of urea molecules intercalated into the kaolinite gallery was studied by means of molecular dynamics simulation. Three main mass losses were observed at 136 °C, in the range of 210–270 °C, and at 500 °C in the TG–DSC curves, which were, respectively, attributed to (1) melting of the surface-adsorbed urea, (2) removal of the intercalated urea, and (3) dehydroxylation of the deintercalated kaolinite. The three DSC endothermic peaks at 218, 250, and 261 °C were related to the successive removals of intercalated urea with three different distribution structures. Based on the angle between the dipole moment vector of urea and the basal surface of kaolinite, the three urea models could be described as follows: (1) Type A, the dipole moment vector is nearly parallel to the basal surface of kaolinite; (2) Type B, the dipole moment vector points to the silica tetrahedron with the angle between it and the basal surface of kaolinite ranging from 20°to 40°; and (3) Type C, the dipole moment vector is nearly perpendicular to the basal surface of kaolinite. The three distribution structures of urea molecules were validated by the results of the molecular dynamics simulation. Furthermore, the thermal behavior of the kaolinite–urea intercalation complex investigated by TG–DSC was also supported by FTIR and XRD analyses.     

基于微纳米压入法的高熵合金柏氏矢量研究

采用微纳米压入法对CoCrFeNiMn高熵合金进行多种应变率下的压入测试研究,实验获得了材料硬度与压深之间的关系并通过计算分析得到了其不同工况下的柏氏矢量值,探究了压入深度和应变率对柏氏矢量的影响．实验结果表明,所测材料柏氏矢量值在一定范围内呈现出一定的波动性,随着压深的增大,柏氏矢量表现出尺寸效应,即柏氏矢量随压深呈增加趋势;并且在同等压深下,柏氏矢量存在率效应,随着应变率的增加,柏氏矢量值先减小后增加,柏氏矢量从滑移主导向原子失配主导的转变是其率效应转变的主要原因．     

A pH-responsive soluble polymer-based homogeneous system for fast and highly efficient N-glycoprotein/glycopeptide enrichment and identification by mass spectrometry

Liquid phase homogeneous reactions using soluble polymer supports have found numerous applications in homogeneous catalysis and organic synthesis because of their advantages of no interface mass transfer limitation and a high conversion rate. However, their application in analytical separation is limited by the inefficient/inconvenient recovery of the target molecules from the extremely complex biological samples. Here, we report a stimuli-responsive polymer system for facile and efficient enrichment of trace amounts of biomolecules from complex biological samples. The soluble polymer supports provide a homogeneous reaction system with fast mass transfer and facilitate interactions between the supports and the target molecules. More importantly, the stimuli-responsive polymers exhibit reversible self-assembly and phase separation under pH variations, which leads to facial sample recovery with a high yield of the target biomolecules. The stimuli-responsive polymer is successfully applied to the enrichment of low abundant N-glycoproteins/glycopeptides, which play crucial roles in various key biological processes in mammals and are closely correlated with the occurrence, progression and metastasis of cancer. N-Glycoprotein is coupled to the stimuli-responsive polymer using the reported hydrazide chemistry with pre-oxidation of the oligosaccharide structure. Highly efficient enrichment of N-glycoproteins/N-glycopeptides with >95% conversion rate is achieved within 1 h, which is eight times faster than using solid/insoluble hydrazide enrichment materials. Mass spectrometry analysis achieves low femtomolar identification sensitivity and obtained 1317 N-glycopeptides corresponding to 458 N-glycoproteins in mouse brain, which is more than twice the amount obtained after enrichment using commercial solid/insoluble materials. These results demonstrate the capability of this “smart” polymer system to combine stimuli-responsive and target-enrichment moieties to achieve improved identification of key biological and disease related biomolecules.     

一种黄土高边坡设计的新方法

根据黄土高边坡破坏面的实际特征,假定最危险滑动面为抛物线型,对高边坡进行可靠度分析,应用数学原理,建立了黄土高边坡的设计模型,并对铜黄一级公路黄土高边坡进行分析验证,结果表明,该方法计算的结果与实际较接近。该方法物理意义明确,易操作,可供设计人员参考。     

光纤耦合二极管端泵2 μm CW双掺)Tm,Ho∶GdVO4激光器

同YLF和YAG 基质相比,在Tm-Ho∶GdVO₄晶体中Tm³⁺离子在800 nm附近有非常强的和宽的吸收带,所以该晶体非常适合商品化的GaAlAs激光二极管泵浦.在液氮制冷晶体条件下,利用光纤耦合激光二极管及消色差光学耦合系统端面泵浦双掺5％Tm,0.5％Ho∶GdVO₄晶体,在泵浦功率14 W、泵浦波长794 nm时,实现了2.048 μm激光输出,连续运转输出功率3.6 W,相应的光光转换效率为25.7％,斜率效率26.6%.相对于吸收的泵浦功率,光光转换效率为35%.由于Tm³⁺离子间的交叉弛豫效应,泵浦量子效率达到1.3.