Nitropyrazoles

The double Vilsmeier formylation of theC-methyl group in pyrazole derivatives has been shown to occur when a nitro-group is in the adjacent position of the ring. A method for the synthesis ofC-(diformylmethyl)nitropyrazoles based on this reaction has been developed.For the previous communication, see Ref. 1; for Part 2, see Ref.2 Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1273–1276, July, 1993.     

Synthesis, band structure, and optical properties of Ba2ZnV2O8

A novel compound Ba₂ZnV₂O₈ has been synthesized in high temperature solution reaction and its crystal structure has been characterized by means of single crystal X-ray diffraction analysis. It crystallizes in monoclinic system and belongs to space group P2₁/c with a=7.9050(16), b=16.149(3), , β=90.49(3). It builds up from 1-D branchy chains of [ZnV₂O₈⁴⁻]_∞, and the Ba²⁺ cations are located in the space among these chains. The IR spectrum, ultraviolet-visible diffuse reflection integral spectrum and fluorescent spectra of this compound have been investigated. The calculated results of energy band structure by the density functional theory method show that the solid-state compound of Ba₂ZnV₂O₈ is an insulator with direct band gap of 3.48 eV. The calculated total and partial density of states indicate that the top valence bands are contributions from the mixings of O-2p, V-3d, and Zn-3d states and low conduction bands mostly originate from unoccupied antibonding states between the V-3d and O-2p states. The V-O bonds are mostly covalence characters and Zn-O bonds are mostly ionic interactions, and the ionic interaction strength is stronger between the Ba-O than between the Zn-O. The refractive index of n_x, n_y, and n_z is estimated to be 1.7453, 1.7469, and 1.7126, respectively, at wavelength of 1060 nm for Ba₂ZnV₂O₈ crystal.     

Determination of nanogram amounts of boron in some antimony compounds

Summary A method has been developed for determining boron in antimony compounds in the range 10^–7–10^–6%. The method comprises the isolation of the boron by distillation as methyl borate and its determination fluorimetrically with dibenzoylmethane. For the three materials analysed, SbCl₃, Sb₂O₃, and SbCl₅, individual procedures of dissolution as well as distillation were developed. The results obtained are reproducible, the mean deviation being about 12% at boron concentrations of 10^–7–10^–6%.

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Zusammenfassung Ein Verfahren zur Bestimmung von 10^–7 bis 10^–6% Bor in Antimon-verbindungen wurde ausgearbeitet. Es umfaßt die Abtrennung des Bors durch Destillation als Methylborat und dessen fluorimetrische Messung mit Dibenzoylmethan. Für SbCl₃, Sb₂O₃ und SbCl₅ wurden jeweils eigene Arbeitsweisen der Auflösung und Destillation angegeben. Die Analysenergebnisse sind reproduzierbar; die mittlere Abweichung beträgt etwa 12% für Borkonzentrationen von 10^–7 bis 10^–6%.

     

Integral intensities of the absorption bands of the skeletal vibrations of substituted furocoumarins

Conclusions The IR spectra of 5- and 8-hydroxyfurocoumarins and their esters, 5,8-disubstituted furocoumarins containing hydroxyl, methoxyl, and alkoxyl groups, and 4,5-dihydrofurocoumarins differ with respect to the intensity and number of the bands in the 1630–1500 cm^–1 region of the spectrum. The integral intensities of the absorption bands in this frequency region differ markedly in the derivatives mentioned.Khimiya Prirodnykh Soedinenii, Vol. 5, No. 5, pp. 355–359, 1969     

Template synthesis in the nickel(II)–thiocarbohydrazide–propanone triple system

The complexing process proceeding in the Ni^II–thiocarbohydrazide (H₂N–H–NC(=S)–NH–NH₂)–propanone triple system in EtOH solution and nickel(II)hexacyanoferrate(II) gelatin-immobilized matrix has been studied. It has been found that in the first case, template synthesis leading, as a minimum, to formation of three coordination compounds of Ni^II with (N,N,S,S)-donor tetradentate ligands having NiL¹, NiL² and NiL³compositions where L¹ is 4,6,6-trimethyl-2,3,7,8-tetraazanonen-3-di(thiohydrazide)-1,9, L² is 4,6,6,12-tetrametyl-1,9-dithio-2,3,7,8,10,11-hexaazatridekadien-3,11-hydrazide-1 and L³ is 2,8,10,10,16-pentamethyl-5,13-dithio-3,4,6,7,11,12,14,15-octaazaheptadekatrien-2,7,15 is observed, whereas in the gelatin-immobilized matrix, a complexing process in the system considered does not occur.     

Characterization of nickel loaded mordenite catalysts by temperature programmed reduction

Temperature programmed reduction (TPR) has been used to study the redox behavior of Ni(II) ions in nickel sodium mordenite (NiNaM) and decationated nickel mordenite (NiHM). The TPR profiles suggest that Ni(II) ions occupy nonequivalent sites with different cooridination states in the mordenite. The reducibility of Ni(II) depends strongly on the zeolite acidity.

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() Ni^II NiNaM NiHM. . .

     

High-throughput cytochrome P450 inhibition screening via cassette probe-dosing strategy. IV. Validation of a direct injection on-line guard cartridge extraction/tandem mass spectrometry method for simultaneous CYP3A4, 2D6 and 2E1 inhibition assessment

A highly efficient direct injection on-line guard cartridge extraction/tandem mass spectrometry (DI-GCE/MS/MS) method has been validated for high-throughput evaluation of cytochrome P450 (CYP) 3A4, 2D6 and 2E1 inhibition potential via cassette dosing of midazolam, dextromethorphan and chlorzoxazone using human hepatic microsomes and 96-well microtiter plates. Microsomal incubations were terminated with formic acid, centrifuged, and the resulting supernatants were injected for analysis by DI-GCE/MS/MS. Due to the novel use of an extremely short C(18) guard cartridge (4 mm in length), this method exhibits several advantages such as no sample preparation, excellent on-line extraction, short run time (2.5 min), and minimized source contamination and performance deterioration. The DI-GCE/MS/MS method demonstrates acceptable accuracy and precision for the simultaneous quantification of 1'-hydroxymidazolam, dextrorphan and 6-hydroxychlorzoxazone in microsomal incubations. The inhibition potential of CYP3A4, 2D6 and 2E1 has been evaluated using their known selective inhibitors. The IC(50) values measured by the cassette dosing approach (high-throughput) are consistent with those observed by an individual dosing regimen (conventional) and are all in good agreement with the literature values. The results suggest that the cassette probe-dosing strategy may provide an in vitro approach to minimize cost while maximizing throughput of CYP inhibition evaluation of new chemical entities in support of drug discovery and development.     

Synthesis of thieno[3.2-<Emphasis Type="Italic">b</Emphasis>]pyrrolenine derivatives under the Fischer reaction conditions

The reaction of alkyl 4-(2-acetylhydrazino)-2-methyl-3-thiophenecarboxylates with 3-methylbutan-2-one was carried out under the Fischer reaction conditions. The influence of Lewis acids and solvents on the process was studied. A convenient method for the synthesis of thieno [3.2-b]pyrrolenine derivatives was proposed.__________Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 725–729, March, 2005.     

Comparative theoretical study of intramolecular proton transfer in the photochemical cycles of 2-(2′-hydroxyphenyl)benzoxazole and 5,8-dimethyl-1-tetralone

We present a comparative golden rule analysis of the dynamics of the intramolecur (IM) hydrogen atom and proton transfer in the photochemical cycles of 2-(2′-hydroxyphenyl)benzoxazole (HBO) and 5,8-dimehtyl-1-tetralone (DMT). Two major effects are taken into consideration: the promoting effect of the IM vibrations which are symmetrically coupled to the reaction coordinate,and the suppressing effect resulting from the reorganization of both the molecule and solvent.

Semiempirical quantum-chemical calculations at the AM1 level were carried out to study the energy levels of all states involved in the photochemical cycles, including the effects of solvation in a polar protic solvent in the case of DMT. Two rotamers E_I and E_II for the enol form of DMT were located corresponding to different positions of the H atom in the hydroxyl group. In the group state the first is more stable both in the gas phase and in polar protic solvents such as diethyl ether—isopentane—ethanol (5:2:5 by volume). Therefore the reketonization reaction is treated as one-step tunneling from the rotamer E_I to the keto form, i.e. without the activated rotational equilibrium E_I↔E_II proposed by Grellmann and coworkers in an earlier study. The steep slope of the kinetic curve of this reaction is attributed to the additional activation energy resulting from the final reorganization of the low frequency oscillators, both intramolecular and solvent. For the dynamic calculations, the standard AM1 output (structural and force field data) was used as the input, and good agreement with the available kinetic experiments was reached for both compounds. No special reasons were found for the similarity of the kinetic curves for triplet excited-state intramolecular proton transfer in HBO and DMT.