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131.
Salgueiriño-Maceira V Hoppe CE Correa-Duarte MA 《The journal of physical chemistry. B》2007,111(2):331-334
Carbon nanotubes (CNTs) based hollow capsules were obtained by degradation under acidic conditions of core-shell nanocomposites build up upon adsorption of multilayers of CNTs (shell) onto melamine-formaldehyde (MF) spheres (core). By evaporation of the dispersions obtained, polymeric fractal patterns from the degradation products of the MF core were formed onto silicon wafers. The proposed mechanism for the formation of these structures is based on the role of the capsules as arrangements of heterogeneities that facilitate the dewetting of the liquid polymeric films. 相似文献
132.
The influence of sodium perfluorooctanoate on the conformational transitions of human immunoglobulin
Messina PV Prieto G Salgado F Varela C Nogueira M Dodero V Ruso JM Sarmiento F 《The journal of physical chemistry. B》2007,111(28):8045-8052
In the field of bioscience, the study of the interactions between blood proteins and fluorinated materials is very important from both theoretical and applied points of view. Fluorinated materials have potential use in drug delivery, as blood substitutes, and in biotechnology. Using a combination of ultraviolet-visible (UV-vis) and ultraviolet-circular dichroism (UV-CD) spectroscopies and ion-selective electrodes, the complete interaction of sodium perfluorooctanoate (SPFO) and the most important immunoglobulin (on a quantitative basis) in human serum, immunoglobulin G (IgG), has been evaluated. The study has been focused on bulk solution. By the application of an SPFO selective electrode, it was determined that there were true specific unions between surfactant molecules and IgG structure. The experimental data were presented as Koltz and Scatchard plots and analyzed on the basis of an empirical Hill equation. The conformational changes at the bulk solution were well characterized by UV-vis and UV-CD spectroscopies. As a consequence of these changes, the protein structure was affected. 相似文献
133.
A Comparative Study of 8‐Hydroxyquinoline and 8‐Hydroxyquinoline‐5‐sulfonic Acid for Antimony(III) Determination by AdSV. Substituent Effect on Sensitivity II
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A sensitive and selective method for the determination of Sb3+ based on the formation of its complexes with 8‐hydroxyquinoline (HQ) and 8‐hydroxyquinoline‐5‐sulfonic acid (HQS) is proposed. The best analytical conditions are: pH 5.4 and 2.2 for HQ and HQS, respectively; CHQ from 15.0 to 25.0 µmol L?1 and CHQS from 70.0 to 200.0 µmol L?1. The detection limits are 100.0 and 14.0 ng L?1 (tacc=30 s) for Sb3+ with HQ and HQS, respectively. The method using HQS as ligand has a 2.2‐fold higher sensitivity than that with HQ and the former was chosen for Sb3+ determination. 相似文献
134.
Guilarte V Fernández-Rodríguez MA García-García P Hernando E Sanz R 《Organic letters》2011,13(19):5100-5103
An efficient synthesis of thiophenes and benzo[b]thiophenes has been developed from easily available bromoenynes and o-alkynylbromobenzene derivatives. This novel one-pot procedure involves a Pd-catalyzed C-S bond formation using a hydrogen sulfide surrogate followed by a heterocyclization reaction. Moreover, in situ functionalization with selected electrophiles further expands the potential of this methodology to the preparation of the corresponding highly substituted sulfur heterocycles. 相似文献
135.
Jessica L��pez-Darias Ver��nica Pino Juan H. Ayala Ana M. Afonso 《Mikrochimica acta》2011,174(3-4):213-222
We have evaluated an in-situ ionic liquid-dispersive liquid-liquid microextraction procedure for the determination of six endocrine disrupting phenols in seawaters and industrial effluents using HPLC. The optimized method requires 38???L of the water-soluble ionic liquid 1-butyl-3-methylimidazolium chloride, and 5?mL of seawater or industrial effluent. After appropriate work-up, a drop (~10???L) of an ionic liquid is formed that contains the analytes of interest. It is diluted with acetonitrile and injected into the HPLC system. This procedure is accomplished without heating or cooling the solutions. The method is characterized by (a) average relative recoveries of 90.2%, (b) enrichment factors ranging from 140 to 989, and (c) precisions (expressed as relative standard deviations) of less than 11% when using a spiking level of 10?ng?mL?1. The limits of detection range from 0.8?ng?mL?1 for 4-cumylphenol to 4.8?ng?mL?1 for bisphenol-A. Figure
Scheme of the in situ IL-DLIME procedure to determine endocrine disrupting phenols in environmental waters. 相似文献
136.
The content of ten phenolic compounds present in four different biomass smoke materials: rock rose (Cistus monpelienisis), prickly pear (Opuntia ficus indica), pine needles (Pinus canariensis), and almonds skin (Prunus dulcis), have been evaluated. The sampling method mainly consisted of a trap alkaline solution to solubilize the phenols, and was optimized by an experimental design. Average sampling efficiencies of 78.1% and an average precision value of 10.6% (as relative standard deviation, RSD), were obtained for the selected group of phenols. The trapped phenolates were further analyzed by a headspace-single drop microextraction (HS-SDME) procedure, in combination with high-performance liquid chromatography (HPLC) with UV detection. The optimum variables for the HS-SDME method were: 1-decanol as extractant solvent, 3.5 μL of microdrop volume, 2 mL of sample volume, a pH value of 2, saturation of NaCl, an extraction temperature of 60 °C, and an extraction time of 25 min. The optimized HS-SDME method presented detection limits ranging from 0.35 to 5.8 μg mL−1, RSD values ranging from 0.7 to 7.4%, and an average relative recovery (RR) of 99.8% and an average standard deviation of 5.2. The average content of phenolic compounds in the biomass materials studied were 70, 161, 206 and 252 mg kg−1 of biomass for prickly pear, almonds skin, rock rose, and pine needles, respectively. The main components of the smokes were vanillin, phenol and methoxyphenols, in all smoking materials studied. 相似文献
137.
Evaluation of various QuEChERS based methods for the analysis of herbicides and other commonly used pesticides in polished rice by LC-MS/MS 总被引:3,自引:0,他引:3
Four different extraction and clean-up protocols based on the QuEChERS method were compared for the development of an optimized sample preparation procedure for the multiresidue analysis of 16 commonly applied herbicides in rice crops using LC-QqQ/MS. Additionally the methods were evaluated for the analysis of 26 insecticides and fungicides currently used in rice crops. The methods comprise, in general, the hydratation of the sample with water followed by the extraction with acetonitrile, phase separation with the addition of different salts and finally a clean-up step with various sorbents.Matrix effects were evaluated for the 4 studied methods using LC-QqQ/MS. Additionally LC-TOF/MS was used to compare the co-extractants obtained with the four assayed methodologies. Thirty-six pesticides presented good performance with recoveries in the range 70-120% and relative standard deviations below 20% using 7.5 g of milled polished rice and the buffered acetate QuEChERS method without clean-up at both fortification levels: 10 and 300 μg kg−1. The other six pesticides presented low recovery rates, nevertheless all these analytes could be analyzed with at least one of the other three studied procedures. 相似文献
138.
Arsequell G Rosa M Mayato C Dorta RL Gonzalez-Nunez V Barreto-Valer K Marcelo F Calle LP Vázquez JT Rodríguez RE Jiménez-Barbero J Valencia G 《Organic & biomolecular chemistry》2011,9(17):6133-6142
To examine if the biological activity of the N/OFQ peptide, which is the native ligand of the pain-related and viable drug target NOP receptor, could be modulated by glycosylation and if such effects could be conformationally related, we have synthesized three N/OFQ glycopeptide analogues, namely: [Thr(5)-O-α-D-GalNAc-N/OFQ] (glycopeptide 1), [Ser(10)-O-α-D-GalNAc]-N/OFQ (glycopeptide 2) and [Ser(10)-O-β-D-GlcNAc]-N/OFQ] (glycopeptide 3). They were tested for biological activity in competition binding assays using the zebrafish animal model in which glycopeptide 2 exhibited a slightly improved binding affinity, whereas glycopeptide 1 showed a remarkably reduced binding affinity compared to the parent compound and glycopeptide 3. The structural analysis of these glycopeptides and the parent N/OFQ peptide by NMR and circular dichroism indicated that their aqueous solutions are mainly populated by random coil conformers. However, in membrane mimic environments a certain proportion of the molecules of all these peptides exist as α-helix structures. Interestingly, under these experimental conditions, glycopeptide 1 (glycosylated at Thr-5) exhibited a population of folded hairpin-like geometries. From these facts it is tempting to speculate that nociceptin analogues showing linear helical structures are more complementary and thus interact more efficiently with the native NOP receptor than folded structures, since glycopeptide 1 showed a significantly reduced binding affinity for the NOP receptor. 相似文献
139.
Migani A Leyva V Feixas F Schmierer T Gilch P Corral I González L Blancafort L 《Chemical communications (Cambridge, England)》2011,47(22):6383-6385
o-Nitrobenzaldehyde is photolabile because of an irreversible phototautomerization, whereas comparable aromatic compounds function as photoprotectors because the tautomerization is reversible. In this experimental and theoretical study we track down the cause of this difference to the electronic changes that occur during the tautomerization. 相似文献
140.
Moore A Celorrio V de Oca MM Plana D Hongthani W Lázaro MJ Fermín DJ 《Chemical communications (Cambridge, England)》2011,47(27):7656-7658
The suitability of insulating highly crystalline diamond particles as support for Pd based electrocatalysts is explored for the first time by evaluating the electrochemical stripping of CO and oxidation of formic acid in acid solutions. 相似文献