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151.
A method for analysis of the global stability of dynamic systems with pulse-width modulation that are presented in the form
of Poincaré mappings is suggested. The method has enhanced efficiency from the viewpoint of the required computing time. Results
of this work can be used for automatic analysis and design of these systems. 相似文献
152.
The optimization of supply chain structures considering both economic and environmental performances is nowadays an important research topic. However, enterprises are commonly faced with the competing issues of reduced cost, improved customer service and increased environmental factors as a multi-faceted trade-off problem when designing supply chains. Hence, this paper proposes an environmentally conscious optimization model of a supply chain network with a broader and more comprehensive objective function that considers not just the transportation costs, but also the costs for the amount of greenhouse gas emissions, fuel consumption, transportation times, noise and road roughness. The paper sheds light on the trade-offs between various parameters such as vehicle speed, fuel, time, emissions, noise and their total cost, and offers managerial insights on economies of environmentally conscious supply chain optimization. An integer non-linear programming model is developed to help decision makers find the optimal solution under mentioned considerations. The proposed model is validated through the solution of an example, where its applicability to supply chain problems is demonstrated for managerial insights. 相似文献
153.
Near‐IR Absorbing BODIPY Derivatives as Glutathione‐Activated Photosensitizers for Selective Photodynamic Action 下载免费PDF全文
Ilke Simsek Turan Fatma Pir Cakmak Deniz Cansen Yildirim Rengul Cetin‐Atalay Prof. Dr. Engin U. Akkaya 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(49):16088-16092
Enhanced spatiotemporal selectivity in photonic sensitization of dissolved molecular oxygen is an important target for improving the potential and the practical applications of photodynamic therapy. Considering the high intracellular glutathione concentrations within cancer cells, a series of BODIPY‐based sensitizers that can generate cytotoxic singlet oxygen only after glutathione‐mediated cleavage of the electron‐sink module were designed and synthesized. Cell culture studies not only validate our design, but also suggest an additional role for the relatively hydrophobic quencher module in the internalization of the photosensitizer. 相似文献
154.
Perihan ünak F. Zümrüt Biber Müftüler ?i?dem ??hedef E. ?lker Medine Kübra ?zmen Turan ünak Ayfer Yurt Kil?ar F. Gül Gümü?er Yasemin Parlak Elvan Say?t Bilgin 《Journal of Radioanalytical and Nuclear Chemistry》2012,293(1):57-66
Diethylstilbestrol (DES) is a well known, nonsteroidal estrogen with high affinity for the estrogen receptor (ER). Today DES is used to treat breast and prostate cancers. A phosphate derivative of DES [Diethylstilbestrol diphosphate (DES-P)] which is specific to tumor cells consisting alkaline phosphatase enzyme was synthesized and labeled with 99mTc using tin chloride as reducing agent. In vivo biological activity of 99mTc labeled diethylstilbestrol phosphate compound (99mTc-DES-P) was examined by biodistribution studies on Wistar Albino rats. Statistical evaluation was performed using SPSS 13 program. The percentage (%) radiolabeling yield of 99mTc-DES-P and quality control studies were done by Thin Layer Radio Chromatography (TLRC). Results showed that, 99mTc-DES-P may be proposed as an imaging agent for ER enriched tumors such as uterus and prostate and their metastases in bones. 相似文献
155.
A plate-strip fabricated from the orthotropic material and containing a crack whose edges are parallel to the face planes of the plate is considered. It is assumed that the strip is stretched (or compressed) initially along the crack edges by uniformly distributed external normal forces acting on the simply supported ends of the plate-strip. After this initial stretching (or compression) the crack edges are loaded by additional uniformly distributed normal (opening) forces. As a result of the action of these additional forces the stress concentration characterized by the stress intensity factor (SIF) of mode I or by the energy release rate (ERR) of mixed mode arises at the crack tips. In this paper, the influence of the initial stresses on the SIF or ERR is modelled mathematically by the use of the three-dimensional linearized theory of elasticity. The aim of the present investigations is to study the effect of the mechanical–orthotropic properties of the plate-strip material on this influence by the use of the finite element method (FEM) modelling of the corresponding boundary-value problem. 相似文献
156.
Sergiu C. Dragomir Matthew Sinnott Eren S. Semercigil Özden F. Turan 《Journal of sound and vibration》2012,331(5):963-973
A study on the energy dissipation characteristics of granular materials flowing/sloshing in a rotating container is presented here. The objective is to develop a configuration for control of excessive structural oscillations, similar to those of tuned vibration absorbers and tuned sloshing absorbers. The effectiveness of energy dissipation through granular flow is primarily determined experimentally. A computational model is developed to understand the flow behavior and energy dissipation in this system. A promising kinematic match of the particle behavior is demonstrated between the numerical predictions and the experimental observations. The use of the granular flow in a rotating drum for vibration control is being investigated for the first time. 相似文献
157.
The problem of active shielding of some domain from the effect of the field generated in another domain is considered. The active shielding is implemented via the placement of additional sources in such a way that the total contribution of all sources leads to the desirable effect. The obtained solution does not require either the knowledge of the particular Green's function or any other information on source distribution and the surrounding medium. It is also important that along with undesirable field to be shielded, a desirable field can be admitted in the analysis. The solution of the problem requires only knowledge of the total field on the perimeter of the shielded domain. The active shielding sources are obtained for both the linear and nonlinear formulations of the problem. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
158.
O. Karabulut M. Parlak K. Yilmaz R. Turan B. G. Akinoglu 《Crystal Research and Technology》2003,38(12):1071-1076
GaSe single crystals grown by Bridgman method have been doped by ion implantation technique. The samples were bombarded in the direction parallel to c‐axis by Si ion beam of about 100 keV to doses of 1 × 1016 ions/cm2 at room temperature. The effects of Si implantation with annealing at 500 and 600 °C on the electrical properties have been studied by measuring the temperature dependent conductivity and photoconductivity under different illumination intensities in the temperature range of 100–320 K. It is observed that Si implantation increases the room temperature conductivity 10−7 to 10−3 (Ω‐cm)−1 depending on the post annealing temperature. The analysis of temperature dependent conductivity shows that at high temperature region above 200 K, the transport mechanism is dominated by thermal excitation in the doped and undoped GaSe samples. At lower temperatures, the conduction of carriers is dominated by variable range hopping mechanism in the implanted samples. Annealing of the samples at and above 600 °C weakens the temperature dependence of the conductivity and photoconductivity. This indicates that annealing of the implanted samples activates Si‐atoms and increases structural deformations and stacking faults. The same behavior was observed from photoconductivity measurements. Hence, photocurrent‐illumination intensity dependence in the implanted samples obeys the power low Ipc ∝ Φn with n between 1 and 2 which is an indication of continuous distribution of localized states in the band gap. (© 2003 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
159.
Tugberk Tabak Kerem Kaya Recep Isci Turan Ozturk Yusuf Yagci Baris Kiskan 《Macromolecular rapid communications》2024,45(2):2300455
A novel method based on light-induced fabrication of a poly (3,4-ethylenedioxythiophene)-polycaprolactone (PEDOT-PCL) scaffold using phenacyl bromide (PAB) as a single-component photoinitiator is presented. HBr released from the step-growth polymerization of EDOT is utilized as an in situ catalyst for the chain-growth polymerization of ε-caprolactone. Detailed investigations disclose the formation of a self-assembled nanoporous electroconductive scaffold (1.2 mS cm−1). Fluorescence emission spectra of the fabricated scaffold exhibit a mixed solvatochromic behavior, indicating specific interactions between the self-assembled scaffold and solvents with varying polarities, as evidenced by transmission electron microscopy (TEM). Moreover, the same light-induced technique can also be applied for bulk photopolymerization showcasing the versatility and wide-ranging scope of the originated method. In brief, this study introduces a novel approach for light-induced polymerization reactions that is merging step-growth and chain-growth mechanisms. This innovative approach is promising to facilitate in situ polymerization of monomers possessing diverse functionalities. 相似文献