Rotaxanated conjugated sensory polymers

Two highly emissive conjugated polymers with tethered rotaxane repeat units are reported. Hydrogen bonding between acidic alcohols and the N-heteroaromatic groups in the rotaxanes attenuates polymer fluorescence. In addition, the rotaxane groups create precise three-dimensional pockets for metal binding, which results in fluorescence quenching. Exposing thin films of Zn-doped polymers to alcohol vapors reverses the quenching by up to 25%.     

Functionalized nanoparticles for liquid atmospheric pressure matrix-assisted laser desorption/ionization peptide analysis

Nanoparticles for the extraction of peptides and subsequent analysis using atmospheric pressure matrix-assisted laser desorption/ionization (APMALDI) have been evaluated. The atmospheric pressure source allows for particles to be directly introduced in the liquid matrix, minimizing sample loss and analysis time. Described in this work are two sample preparation procedures for liquid APMALDI analysis: a C18 functionalized silica nanoparticle for hydrophobic extractions, and an aptamer functionalized magnetite core nanoparticle for rapid, affinity extractions. The C18 particles provide a non-selective support for rapid profiling applications, while the aptamer particles are directed towards reducing the complexity in biological samples. The aptamer functionalized particles provide a more selective analyte-nanoparticle interaction whereby the tertiary structure of the analyte becomes more critical to the extraction. In both cases, the liquid APMALDI matrix provides a support for ionization, and acts as the releasing agent for the analyte-particle interaction. Additionally, analyte enrichment was possible due to the large surface-to-volume ratio of the particles. The experiments conducted with functionalized nanoparticles, in an atmospheric pressure liquid matrix, present a basis for further methodologies and utilities of silica nanoparticles to be developed.     

Solvation largely accounts for the effect of N-alkylation on the properties of nickel(II/I) and chromium(III/II) cyclam complexes

The source of the effect of N-alkylation on the redox properties of Ni(II/I) and Cr(III/II) cyclam complexes has been investigated using DFT calculations. The structures of the anhydrous and hydrated complexes were optimized in the gas phase, and single point calculations were performed in a polarized continuum. The main results are the following: the decrease in outer sphere solvation upon N-alkylation is the major source of the relative stabilization of the lower oxidation state complexes by the tertiary amine ligands; tertiary amine nitrogen donors are stronger sigma-donors than the secondary amines, as predicted from the inductive effect of alkyls; steric strain elongates the metal-nitrogen bonds in the tertiary complexes and decreases the ligand strain energies; and the site of water binding to the complexes differs because of their different electronic structures (i.e., in the Ni complexes, the water molecules bind to the M[bond]N[bond]H sites, whereas in the Cr complexes they bind to the central metal cation). Outer sphere hydrogen bonding of water to the ligands in the coordination sphere lowers the ionization potentials by charge delocalization.     

Triazene proton affinities: A comparison between density functional,Hartree–Fock,and post-Hartree–Fock methods

The consistency of three density functional computational implementations (DMol, DGauss, and deMon) are compared with high-level Hartree–Fock and Møller–Plesset (MP) calculations for triazene (HN?NNH₂) and formyl triazene (HN?NNHCOH). Proton affinities on all electronegative sites are investigated as well as the geometries of the neutral and protonated species. Density functional calculations employing the nonlocal gradient corrections show agreement with MP calculations for both proton affinities and geometries of neutral and protonated triazenes. Local spin density approximation DMol calculations using numerical basis sets must employ an extended basis to agree with other density functional codes using analytic Gaussian basis sets. The lowest energy conformation of triazene was found to be nonplanar; however, the degree of nonplanarity, as well as some bond lengths, is dependent on the basis set, electron correlation treatment, and methods used for the calculation. © 1994 by John Wiley & Sons, Inc.

1 This article is a U.S. Government work and, as such, is in the public domain in the United States of America.

     

Modulated potential electrogenerated chemiluminescence of luminol and Ru(bpy) 3 2+

Chemiluminescence emission intensity is modulated by modulating the potential of a working electrode which is used to generate a key species in the electrogenerated Chemiluminescence (ECL) reaction. The emission is monitored synchronously using a lock-in amplifier. The reactions used in the characterization are luminol with hydrogen peroxide and tris(2,2-bipyridyl)ruthenium (II) (or Ru(bpy) ₃ ²⁺ ) with oxalate. Modulation widths of ± 50 mV yield maximum signals for luminol when centered at 0.45 V (vs Ag/AgCl) and for Ru(bpy) ₃ ²⁺ when centered at 1.05 V. The resulting signal decreases with increasing modulation frequency and shows that luminol/H₂O₂ is a faster ECL system than Ru(bpy) ₃ ²⁺ /oxalate. Working curves for luminol and for oxalate have essentially the same linear range and slope with the modulated potential approach as with a DC electrode potential. This approach provides capability for differentiating the analytical signal from constant background emission or stray light.     

Greenhouse gas abatement — toward Pareto-optimal decisions under uncertainty

This paper examines the economic logic of integrated assessment — balancing the costs against the benefits of greenhouse gas abatement. Stylized facts are employed in a multiregion computable general equilibrium model with a public good. The percentage shares of global emissions are determined outside the model — based upon some form of international agreement — and emission rights are tradeable between regions. The analysis is confined to Pareto-optimal (cooperative) solutions. We focus on the sensitivity of initial decisions to low-probability, high-consequence scenarios associated with cumulative emissions. For simplicity, there are only two regions, two tradeable goods, two time periods, and two states-of-world. With the particular form of public good model adopted here (production rather than utility function impacts), it turns out that a Pareto-optimal hedging strategy is indepedent of the emission shares allocated to each region. Equity issues may be separated from those of economic efficiency. Similar results extend to cases in which there are additional regions, tradeable goods, time periods, and states-of-world.Presented at the Conference on the Economics of Global Environmental Change, Birmingham University, May 9–11, 1994. This research was funded by the Electric Power Research Institute (EPRI). The views presented here are solely those of the individual authors, and do not necessarily represent the views of EPRI or its members.     

Development of Molecular Mechanics Torsion Parameters for alpha,beta-Cyclopropyl Ketones and Conformational Analysis of Bicyclo[m.1.0]alkan-2-ones

Conformations of cyclopropyl methyl ketone have been studied using ab initio methods in an effort to quantify the effects of conjugative overlap between the cyclopropane ring and an adjacent ketone carbonyl. Results were comparable with previous experimental and theoretical studies. Cyclopropyl methyl ketone exhibits a global energy minimum in the s-cis conformer and a local energy minimum near the s-trans conformer. The potential energy curve obtained was used to derive torsion parameters which were employed in molecular mechanics studies of the conformations of the set of bicyclo[m.1.0]alkan-2-ones having larger ring sizes from five- to 16-membered. Similar conformations for the cyclopropyl ketone substructure are observed for all the medium and large ring systems examined. Possible synthetic ramifications of local conformational anchoring by this functional group array are discussed.