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111.
A series of 5-trichloro-Δ4-1,2,4-oxadiazolines have been synthesised by 1,3-dipolar cycloaddition of nitrones to trichloroacetonitrile. These oxadiazolines rearrange into formamidine derivatives, via ring opening and a 1,2-aryl shift from carbon to the adjacent amino nitrogen. Both cycloaddition and rearrangement are facilitated when electron deficient nitriles and electron rich nitrones are used. 相似文献
112.
113.
Clarissa Müller Tim Ortmann Akram Abi Dave Hartig Stephan Scholl Hans-Joachim Jördening 《Applied biochemistry and biotechnology》2017,182(1):197-215
Immobilization methods and carriers were screened for immobilization of Euglena gracilis extract with laminaribiose phosphorylase activity. The extract was successfully immobilized on three different carriers via covalent linkage. Suitable immobilization carriers were Sepabeads EC-EP/S and ECR 8209M with epoxy groups and ECR 8309M with amino groups as functional units. Immobilization on Sepabeads EC-EP/S resulted in highest retained activity (65%). The immobilizates were characterized for pH, temperature, and buffer molarity preferences. The immobilized enzyme lost 48% of its activity when used seven times. Together with sucrose phosphorylase, laminaribiose phosphorylase was successfully applied for bienzymatic production of laminaribiose from sucrose and glucose with a final laminaribiose concentration of 14.3 ± 2.1 g/L (20% yield). 相似文献
114.
Tavorite‐structured oxyphosphates, fluorophosphates, oxysulfates, and fluorosulfates are evaluated for use as cathode materials in lithium ion batteries and activation energies for lithium diffusion through LiVO(PO4), LiV(PO4)F, and LiFe(SO4)F are calculated. 相似文献
115.
Hans J. Breunig Tim Koehne Ana Maria Preda Cristian Silvestru Luis F. Piedra-Garza 《Journal of organometallic chemistry》2010,695(9):1307-1313
The syntheses and spectroscopic (NMR, MS) investigations of the antimonates [Ph4P]+[Me2SbCl4]− (1), [Me4Sb]+[Me2SbCl4]− (2), [Et4N]+[Ph2SbCl4]− (3), [Bu4N]+[Ph2SbCl4]− (4), [Me4Sb]+[Ph2SbCl4]− (5), [Et3MeSb]+[Ph2SbCl4]− (6), [Et4N]+[Ph2SbF4]− (7) and [Et4N]+[Ph2SbBr4]− (8) are reported. Halogen scrambling reactions of Et4NBr or Ph4EBr (E = P, Sb) with R2SbCl3 (R = Me, Ph) produce mixtures of compounds from which crystals of [Et4N]+[Ph2SbBr1.24Cl2.76]− (9), [Et4N]+[Ph2SbBr2.92Cl1.08]− (10) or [Ph4Sb]+[Me2SbCl4]− (11) were isolated. The crystal and molecular structures of 1 and 3-11 are reported. 相似文献
116.
Vladimir Strezov Artur Ziolkowski Tim J. Evans Peter F. Nelson 《Journal of Thermal Analysis and Calorimetry》2010,100(3):901-907
Ironmaking involves reduction of iron ores to metallic iron using coke, coal or gas as reductants. Although different iron ore reduction processes exist, prior to each reduction type, commonly, the hydroxyl and clay materials present in the iron ores undergo decomposition as a first stage. The mass loss during decomposition of these materials is termed as Loss on Ignition (LOI). The aim of this work is to apply a computer aided thermoanalytical technique to evaluate five different iron ore types during decomposition of the LOI matter and determine associated decomposition temperature ranges and heats of reactions. Fourier Transform Infrared (FTIR) spectroscopy and thermogravimetric analysis (TG) were also incorporated to support the analysis interpretation. Three distinctive temperature ranges of decomposition of iron ore LOI matter were detected. The first region was associated with dehydration of the hygroscopic moisture at a temperature range between 100 and 150 °C. The second region occurred at a temperature range between 260 and 425 °C during which strongly bonded water was released and the OH groups associated with primarily iron oxyhydroxides were fractured. The third range, which occurred at a temperature range of 530 and 605 °C, was related to decomposition of the aluminosilicate clay materials. 相似文献
117.
Tim Desmet T. Billiet Elke Berneel Ria Cornelissen David Schaubroeck Etienne Schacht Peter Dubruel 《Macromolecular bioscience》2010,10(12):1484-1494
In the last decade, substantial research in the field of post‐plasma grafting surface modification has focussed on the introduction of carboxylic acids on surfaces by grafting acrylic acid (AAc). In the present work, we report on an alternative approach for biomaterial surface functionalisation. Thin poly‐ε‐caprolactone (PCL) films were subjected to a dielectric barrier discharge Ar‐plasma followed by the grafting of 2‐aminoethyl methacrylate (AEMA) under UV‐irradiation. X‐ray photoelectron spectroscopy (XPS) confirmed the presence of nitrogen. The ninhydrin assay demonstrated, both quantitatively and qualitatively, the presence of free amines on the surface. Confocal fluorescence microscopy (CFM), atomic force microscopy (AFM) and scanning electron microscopy (SEM) were used to visualise the grafted surfaces, indicating the presence of pAEMA. Static contact angle (SCA) measurements indicated a permanent increase in hydrophilicity. Furthermore, the AEMA grafted surfaces were applied for comparing the physisorption and covalent immobilisation of gelatin. CFM demonstrated that only the covalent immobilisation lead to a complete coverage of the surface. Those gelatin‐coated surfaces obtained were further coated using fibronectin. Osteosarcoma cells demonstrated better cell‐adhesion and cell‐viability on the modified surfaces, compared to the pure PCL films.
118.
Tim De Meyer Davy Sinnaeve Bjorn Van Gasse Ernst-R Rietzschel Marc L. De Buyzere Michel R. Langlois Sofie Bekaert José C. Martins Wim Van Criekinge 《Analytical and bioanalytical chemistry》2010,398(4):1781-1790
Proton nuclear magnetic resonance (1H-NMR)-based metabolomics enables the high-resolution and high-throughput assessment of a broad spectrum of metabolites in
biofluids. Despite the straightforward character of the experimental methodology, the analysis of spectral profiles is rather
complex, particularly due to the requirement of numerous data preprocessing steps. Here, we evaluate how several of the most
common preprocessing procedures affect the subsequent univariate analyses of blood serum spectra, with a particular focus
on how the standard methods perform compared to more advanced examples. Carr–Purcell–Meiboom–Gill 1D 1H spectra were obtained for 240 serum samples from healthy subjects of the Asklepios study. We studied the impact of different
preprocessing steps—integral (standard method) and probabilistic quotient normalization; no, equidistant (standard), and adaptive-intelligent
binning; mean (standard) and maximum bin intensity data summation—on the resonance intensities of three different types of
metabolites: triglycerides, glucose, and creatinine. The effects were evaluated by correlating the differently preprocessed
NMR data with the independently measured metabolite concentrations. The analyses revealed that the standard methods performed
inferiorly and that a combination of probabilistic quotient normalization after adaptive-intelligent binning and maximum intensity
variable definition yielded the best overall results (triglycerides, R = 0.98; glucose, R = 0.76; creatinine, R = 0.70). Therefore, at least in the case of serum metabolomics, these or equivalent methods should be preferred above the
standard preprocessing methods, particularly for univariate analyses. Additional optimization of the normalization procedure
might further improve the analyses. 相似文献
119.
Tim Geppert Ewgenij Proschak Gisbert Schneider 《Journal of computational chemistry》2010,31(9):1919-1928
We present a computational approach to protein‐protein docking based on surface shape complementarity (“ProBinder”). Within this docking approach, we implemented a new surface decomposition method that considers local shape features on the protein surface. This new surface shape decomposition results in a deterministic representation of curvature features on the protein surface, such as “knobs,” “holes,” and “flats” together with their point normals. For the actual docking procedure, we used geometric hashing, which allows for the rapid, translation‐, and rotation‐free comparison of point coordinates. Candidate solutions were scored based on knowledge‐based potentials and steric criteria. The potentials included electrostatic complementarity, desolvation energy, amino acid contact preferences, and a van‐der‐Waals potential. We applied ProBinder to a diverse test set of 68 bound and 30 unbound test cases compiled from the Dockground database. Sixty‐four percent of the protein‐protein test complexes were ranked with an root mean square deviation (RMSD) < 5 Å to the target solution among the top 10 predictions for the bound data set. In 82% of the unbound samples, docking poses were ranked within the top ten solutions with an RMSD < 10 Å to the target solution. © 2010 Wiley Periodicals, Inc. J Comput Chem, 2010 相似文献
120.
Durković M Habigt T Rothbucher M Diepold K 《The Journal of the Acoustical Society of America》2011,130(6):EL392-EL398
Sound source localization algorithms determine the physical position of a sound source in respect to a listener. For practical applications, a localization algorithm design has to take into account real world conditions like multiple active sources, reverberation, and noise. The application can impose additional constraints on the algorithm, e.g., a requirement for low latency. This work defines the most important constraints for practical applications, introduces an algorithm, which tries to fulfill all requirements as good as possible, and compares it to state-of-the-art sound source localization approaches. 相似文献