Characterization of iodine species in the marine aerosol: To understand their roles in particle formation processes

In this contribution, iodine chemistry in the Marine Boundary Layer (MBL) is introduced. A series of methodologies for the measurements of iodine species in the gas and particle phases of the coastal atmosphere has been developed. Iodine species in the gas phase in real air samples has been determined in two field campaigns at the west coast of Ireland, indicating that gaseous iodo-hydrocarbons and elemental iodine are the precursors of new particle formation. Particulate iodine speciation from the same measurement campaigns show that the non-water-soluble iodine compounds are the main iodine species during the marine particle formation. A seaweed-chamber experiment was performed, indicating that gaseous I₂ is one of the important precursors that lead to new particle formation in the presence of solar light in the ambient air at the coastal tidal area.     

A combined ESI- and MALDI-MS(/MS) study of peripherally persulfonylated dendrimers: false negative results by MALDI-MS and analysis of defects

Mass spectrometry, in particular MALDI-MS, has often been used as a valuable means to characterize dendritic molecules with respect to their molecular masses. Also, it is a valuable tool for analyzing potential defects in their structure which result from incomplete synthetic steps. This article presents a comparison of ESI and MALDI mass spectrometric experiments on dendrimers persulfonylated at their periphery. While the ESI mass spectra easily permit impurities and defects to be identified and thus provide evidence for sample purity, reactions with acidic matrices occur during the MALDI process. The resulting defects are identical to those expected from incomplete substitution. Thus, in these cases, MALDI-MS yields false negative results. With mass-selected, ESI-generated ions, collision experiments were performed in an FT-ICR mass spectrometer cell to provide detailed insight into the fragmentation patterns of the various dendrimers. Different fragmentation patterns are observed depending on the exact structure of the dendrimer. Also, the nature of the charge is important. The fragmentation reactions for protonated species differ much from those binding a sodium or potassium ion. These differences can be traced back to different sites for binding H+ versus Na+ or K+. Tandem MS experiments on mass-selected dendrimer ions with defects can be used to distinguish different types of defects. A concise structural assignment can thus be made on the basis of these experiments. Even mixtures of two isobaric defect variants with the same elemental composition can be identified.     

A new interface to couple thin-layer chromatography with laser desorption/atmospheric pressure chemical ionization mass spectrometry for plate scanning

An interface to allow on-line qualitative and quantitative full-plate detection and analysis of compounds separated by thin-layer chromatography (TLC) is presented. A continuous wave diode laser is employed as a desorption source. Atmospheric pressure chemical ionization mass spectrometry ionizes and subsequently identifies the desorbed sample molecules. Besides direct laser desorption on untreated TLC plates, graphite particles were used as a matrix to couple in the laser power and improve the efficiency of desorption.     

Synthesis and characterization of the SO(2)N(3)(-), (SO(2))(2)N(3)(-), and SO(3)N(3)(-) anions

SO(2) solutions of azide anions are bright yellow, and their Raman spectra indicate the presence of covalently bound azide. Removal of the solvent at -64 degrees C from CsN(3) or N(CH(3))(4)N(3) solutions produces yellow (SO(2))(2)N(3)(-) salts. Above -64 degrees C, these salts lose 1 mol of SO(2), resulting in white SO(2)N(3)(-) salts that are marginally stable at room temperature and thermally decompose to the corresponding azides and SO(2). These anions were characterized by vibrational and (14)N NMR spectroscopy and theoretical calculations. Slow loss of the solvent by diffusion through the walls of a sealed Teflon tube containing a sample of CsSO(2)N(3) in SO(2) resulted in white and yellowish single crystals that were identified by X-ray diffraction as CsSO(2)N(3).CsSO(3)N(3) with a = 9.542(2) A, b = 6.2189(14) A, c = 10.342(2) A, and beta = 114.958(4) degrees in the monoclinic space group P2(1)/m, Z = 2, and Cs(2)S(2)O(5).Cs(2)S(2)O(7).SO(2), respectively. Pure CsSO(3)N(3) was also prepared and characterized by vibrational spectroscopy. The S-N bond in SO(2)N(3)(-) is much weaker than that in SO(3)N(3)(-), resulting in decreased thermal stability, an increase in the S-N bond distance by 0.23 A, and an increased tendency to undergo rotational disorder. This marked difference is due to SO(3) being a much stronger Lewis acid (pF(-) value of 7.83) than SO(2) (pF(-) value of 3.99), thus forming a stronger S-N bond with the Lewis base N(3)(-). The geometry of the free gaseous SO(2)N(3)(-) anion was calculated at the RHF, MP2, B3LYP, and CCSD(T) levels. The results show that only the correlated methods correctly reproduce the experimentally observed orientation of the SO(2) group.     

Palladium-catalyzed alkylation-hydride reduction sequence: synthesis of meta-substituted arenes

A new three-component, palladium-catalyzed domino reaction which gives access to meta-substituted arenes using aryl iodides and primary alkyl halides is reported. Various functional groups are tolerated on both the aryl iodide and alkyl halide. In addition, isotopic labeling studies provide insight into the mechanism of this Catellani-type reaction. [reaction: see text]     

Nucleophilicities of nitroalkyl anions

The kinetics of the reactions of eight nitroalkyl anions (nitronate anions) with benzhydrylium ions and quinone methides in DMSO and water were investigated photometrically. The second-order rate constants were found to follow a Ritchie constant selectivity relationship with slightly smaller selectivities than those observed previously for other carbanions and O or N nucleophiles. Evaluation of the kinetic data by the correlation equation log k (20 degrees C) = s(N + E) yields the nucleophilicity parameters (N), which allow a comparison of the nucleophilicities of nitronates with those of other classes of compounds. Although the aliphatic nitronates 1a-c are more nucleophilic than the aromatic representatives 1d-h in DMSO, hydration reduces the nucleophilicities of aliphatic nitronates by a factor of 1 million, which is considerably greater than the reduction of the reactivities of the aromatic nitronates with the consequence that aromatic nitronates are more nucleophilic in water than aliphatic ones. The nucleophilic reactivities of nitronates are only slightly affected by substituent variation in DMSO and even less so in aqueous solution, which is considered to be the reason for the unusual rate equilibrium relationships, the so-called nitroalkane anomaly. Outer-sphere electron transfer does not occur in any of the reactions that were investigated.     

β -Cyclodextrin-Mediated Regioselective Hydrolysis of 5,10,15,20-tetrakis[2,4-bis(pivaloyloxy)phenyl]-21H,23H -porphine

The four peripheral ester moieties of the title compound 5 are regioselectively hydrolyzed under mild conditions in the presence of β -cyclodextrin ( 10 ), providing a new entry to tetraphenylporphyrin derivatives with differently substituted Ph groups in the meso-positions. UV, ¹H-NMR and mass spectroscopy of the inclusion complex 9 of 2,6-O-dimethyl-β-cyclodextrin ( 12 ) and 5 indicate a stoichiometry of 2:1 for 10/5 . Moreover, calculations confirm NOE experiments consistent with the fact that the cyclodextrins 10 and 12 approach the Ph groups of the porphyrin with the small opening of the cavity (primary face).