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971.
Tatiana Z. Nichele 《Tetrahedron letters》2007,48(42):7472-7475
A catalyst precursor prepared in situ from palladium acetate and a phosphine ligand was used for the Stille cross-coupling reaction of benzylic bromides and chlorides with aryltributyltin analogues. The reactions were performed at 80 °C using dppf as ligand in the presence of KF, or more conveniently using PPh3 in the absence of base, furnishing diarylmethane derivatives in high yields (86-99%). Using Pd(OAc)2/PPh3 as catalyst precursor competitive Stille and Suzuki cross-coupling reactions with benzyl chloride showed that in the absence of base or in the presence of KF the Stille product is the majority product, and only the Suzuki product was obtained in the presence of KOH as base. 相似文献
972.
Draguta Sergiu Fonari Marina S. Bejagam Shabari Nath Storms Kathryn Lindline Jennifer Timofeeva Tatiana V. 《Structural chemistry》2016,27(4):1303-1315
Structural Chemistry - A solvent co-crystallization of three 2-aminopyridine derivatives, 2-aminopyridine (AP), 2-amino-6-methylpyridine (AMP), and 2,6-diaminopyridine (DAP) with the odd-membered... 相似文献
973.
[reaction: see text] Photochromic dithienylethene moieties were covalently attached to fluorescent 4,4-difluoro-8-(4'-iodophenyl)-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene (iodo-BODIPY) via a phenylacetylene linker. UV light induced isomerization of the photochrome results in significant decrease in fluorescence intensity. This fluorescence can be recovered with visible light. Steady-state fluorescence measurements demonstrate that the emission of the dye can be modulated by external light. An intramolecular energy transfer mechanism accounts for the fluorescence quenching in the UV light produced isomers. 相似文献
974.
A fullerene-paclitaxel chemotherapeutic: synthesis, characterization, and study of biological activity in tissue culture 总被引:1,自引:0,他引:1
Zakharian TY Seryshev A Sitharaman B Gilbert BE Knight V Wilson LJ 《Journal of the American Chemical Society》2005,127(36):12508-12509
A fullerene-paclitaxel conjugate has been synthesized as a slow-release drug for aerosol liposome delivery of paclitaxel for lung cancer therapy. The conjugate was designed to release paclitaxel via enzymatic hydrolysis and subsequently has shown a half-life of release of 80 min in bovine plasma. A liposome formulation of the conjugate has been prepared using dilauroylphosphatidylcholine (DLPC), and its IC50 is virtually identical to the IC50 for a paclitaxel-DLPC formulation in human epithelial lung carcinoma A549 cells. With both clinically relevant kinetics of hydrolysis and significant cytotoxicity in tissue culture, the conjugate holds promise for enhanced therapeutic efficacy of paclitaxel in vivo. 相似文献
975.
Tatiana K. Bronich Andrew Nehls Adi Eisenberg Victor A. Kabanov Alexander V. Kabanov 《Colloids and surfaces. B, Biointerfaces》1999,16(1-4):243-251
In this paper we have evaluated a novel family of polymer-surfactant complexes formed between block ionomers and oppositely charged surfactants. Complexes between cationic copolymer poly(ethylene oxide)-g-polyethyleneimine (PEO-g-PEI) and sodium salt of oleic acid, natural nontoxic surfactant, are prepared and characterized. These systems self-assemble in aqueous solutions into particles with average size of 50–60 nm, which can solubilize hydrophobic dyes (Yellow OB) and drug molecules (paclitaxel). The use of the biologically active surfactants as components of block ionomer complexes is demonstrated for the complexes from PEO-g-PEI and all-trans-retinoic acid. Binding of relatively soluble drugs with block ionomers is illustrated using PEO-b-poly(sodium methacrylate) and doxorubicin. Overall these studies suggest that block ionomer complexes can be used to prepare a variety of soluble and stable formulations of biologically active compounds, and have potential application as drug delivery systems 相似文献
976.
Tatiana M. Birshtein Ekaterina B. Zhulina Alexey A. Polotsky Volker Abetz Reimund Stadler 《Macromolecular theory and simulations》1999,8(2):151-160
The theory of lamellar superstructures in binary mixtures of AB diblock and linear ABC triblock copolymers under the condition of strong segregation between chemically different blocks is developed. This system is considered using Alexander‐de Gennes (box‐model) and self‐consistent field (SCF) models. The formation of a mixed lamellar superstructure comprising both mixture components is proved. It is shown that a mixed lamella may be the only type of lamellae in the mixture, or it may coexist with pure diblock lamellae, depending on the mixture composition, local characteristics of blocks (thickness and Kuhn segment length), and surface tension coefficients at the A/B and B/C interfaces. Preliminary experimental results provide support of these theoretical estimations. The formation of mixed lamellae in a mixture of linear ABC and branched (AB)2C block copolymers is also considered. 相似文献
977.
High-performance monolithic disk chromatography (HPMDC), including its affinity mode, is a very efficient method for fast separations of biological molecules of different sizes and shapes. In this paper, protein and peptide ligands, immobilized on the inner surface of thin, monolithic supports (Convective Interaction Media or CIM disks), have been used to develop methods for fast, quantitative affinity fractionation of pools of polyclonal antibodies from blood sera of rabbits, immunized with complex protein-peptide conjugates. The combination of several disks with different affinity functionalities in the same cartridge enables the separation of different antibodies to be achieved within a few minutes. The apparent dissociation constants of affinity complexes were determined by frontal analysis. Variation of elution flow rate over a broad range does not affect the affinity separation characteristics. Indifferent synthetic peptides used as biocompatible spacers do not change the affinity properties of the ligands. The highly reproducible results of immunoaffinity HPMDC are compared with data obtained by widely used enzyme-linked immunosorbent assay. 相似文献
978.
Larry R. Falvello Eva M. Miqueleiz Tatiana Soler Milagros Toms 《Acta Crystallographica. Section C, Structural Chemistry》2003,59(11):m442-m445
In the title compound, [ZnCl2(C3H6N2O)2], the zinc(II) cation is surrounded by a distorted tetrahedral environment consisting of two Cl anions and two imidazolidin‐2‐one molecules, the latter bound to the metal through their carbonyl O atoms. All atoms that are able to participate in hydrogen bonding are involved in such interactions. A hydrogen‐bonding network mediates the formation of molecular columns parallel to the a axis. Neighboring columns are not bound by significant non‐covalent interactions; the result is an extended pattern of supramolecular aggregation that is intermediate in completeness between the situations observed in two related complexes of cobalt that have been studied previously. 相似文献
979.
Wolff JJ Laremore TN Busch AM Linhardt RJ Amster IJ 《Journal of the American Society for Mass Spectrometry》2008,19(2):294-304
The structural characterization of glycosaminoglycans (GAG) oligosaccharides has been a long-standing challenge in the field of mass spectrometry. In this work, we present the application of electron detachment dissociation (EDD) Fourier transform mass spectrometry to the analysis of dermatan sulfate (DS) oligosaccharides up to 10 residues long. The EDD mass spectra of DS oligosaccharides were compared with their infrared multiphoton dissociation (IRMPD) mass spectra. EDD produces more abundant fragmentation than IRMPD with far less loss of SO3 from labile sulfate modifications. EDD cleaves all glycosidic bonds, yielding both conventional glycosidic bond fragmentation as well as satellite peaks resulting from the additional loss of 1 or 2 hydrogen atoms. EDD also yields more cross-ring fragmentation than IRMPD. For EDD, abundant cross-ring fragmentation in the form of A- and X-ions is observed, with 1,5Xn cleavages occurring for all IdoA residues and many of the GalNAc4S residues, except at the reducing and nonreducing ends. In contrast, IRMPD produces only A-type cross-ring fragmentation for long oligosaccharides (dp6-dp10). As all the structurally informative fragment ions observed by IRMPD appear as a subset of the peaks found in the EDD mass spectrum, EDD shows great potential for the characterization of GAG oligosaccharides using a single tandem mass spectrometry experiment. 相似文献
980.
The theory of lamellar superstructures in ternary mixtures of ab and bc diblock and linear ABC triblock copolymers under the condition of strong segregation between chemically different blocks is developed. This system is considered using Alexander‐de Gennes (box) and self‐consistent field (SCF) models. The theory predicts the possibility of phase segregation in the microphase‐segregated superstructures. It is shown that the ABC triblock copolymer has unlimited capacity with respect to ab and bc diblock copolymers which include cooperatively into mixed lamella. 相似文献