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141.
Tao Wang Dr. Yuzhou Wu Dr. Seah Ling Kuan Oliver Dumele Dr. Markus Lamla Dr. David Y. W. Ng Matthias Arzt Jessica Thomas Jan O. Mueller Prof. Dr. Christopher Barner‐Kowollik Prof. Dr. Tanja Weil 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(1):228-238
A disulfide intercalator toolbox was developed for site‐specific attachment of a broad variety of functional groups to proteins or peptides under mild, physiological conditions. The peptide hormone somatostatin (SST) served as model compound for intercalation into the available disulfide functionalization schemes starting from the intercalator or the reactive SST precursor before or after bioconjugation. A tetrazole–SST derivative was obtained that undergoes photoinduced cycloaddition in mammalian cells, which was monitored by live‐cell imaging. 相似文献
142.
Dr. Alasdair I. McKay Dr. James Barwick-Silk Max Savage Prof. Michael C. Willis Prof. Andrew S. Weller 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(13):2883-2889
The synthesis of rhodium complexes with weakly binding highly fluorinated benzene ligands is described: 1,2,3-F3C6H3, 1,2,3,4-F4C6H2 and 1,2,3,4,5-F5C6H are shown to bind with cationic [Rh(Cy2P(CH2)xPCy2)]+ fragments (x=1, 2). Their structures and reactivity with alkenes, and use in catalysis for promoting the Tishchenko reaction of a simple aldehyde, are demonstrated. Key to the synthesis of these complexes is the highly concentrated reaction conditions and use of the [Al{OC(CF3)3}4]− anion. 相似文献
143.
144.
Magnus Pfaffenbach Dipl.‐Wirtschaftsing. Alexander Roller Prof. Dr. Tanja Gaich 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(25):8444-8447
Herein, we report the synthetically practical, short, and general access to novel indolophane architectures by means of a photochemical C?H activation process—the Witkop cyclization. These highly strained scaffolds were obtained by photoinduced ring closure and feature atropisomerism as well as aromatic ring current effects, which both have been investigated. The prevailing regioselectivity of theWitkop cyclization reaction was completely reversed by the presence of a quaternary carbon center, exerting a strong Thorpe–Ingold effect on the system for which experimental‐evidence is provided. 相似文献
145.
146.
Amrita Chakraborty Ann Candice Fernandez Dr. Anirban Som Biswajit Mondal Dr. Ganapati Natarajan Dr. Ganesan Paramasivam Dr. Tanja Lahtinen Prof. Hannu Häkkinen Dr. Nonappa Prof. Thalappil Pradeep 《Angewandte Chemie (International ed. in English)》2018,57(22):6522-6526
The self‐assembled structures of atomically precise, ligand‐protected noble metal nanoclusters leading to encapsulation of plasmonic gold nanorods (GNRs) is presented. Unlike highly sophisticated DNA nanotechnology, this strategically simple hydrogen bonding‐directed self‐assembly of nanoclusters leads to octahedral nanocrystals encapsulating GNRs. Specifically, the p‐mercaptobenzoic acid (pMBA)‐protected atomically precise silver nanocluster, Na4[Ag44(pMBA)30], and pMBA‐functionalized GNRs were used. High‐resolution transmission and scanning transmission electron tomographic reconstructions suggest that the geometry of the GNR surface is responsible for directing the assembly of silver nanoclusters via H‐bonding, leading to octahedral symmetry. The use of water‐dispersible gold nanoclusters, Au≈250(pMBA)n and Au102(pMBA)44, also formed layered shells encapsulating GNRs. Such cluster assemblies on colloidal particles are a new category of precision hybrids with diverse possibilities. 相似文献
147.
Prof. Dr. Petra Schwille Prof. Dr. Joachim Spatz Prof. Dr. Katharina Landfester Prof. Dr. Eberhard Bodenschatz Prof. Dr. Stephan Herminghaus Prof. Dr. Victor Sourjik Dr. Tobias J. Erb Prof. Dr. Philippe Bastiaens Prof. Dr. Reinhard Lipowsky Prof. Dr. Anthony Hyman Prof. Dr. Peter Dabrock Dr. Jean‐Christophe Baret Dr. Tanja Vidakovic‐Koch Dr. Peter Bieling Dr. Rumiana Dimova Dr. Hannes Mutschler Dr. Tom Robinson Dr. T.‐Y. Dora Tang Dr. Seraphine Wegner Prof. Dr. Kai Sundmacher 《Angewandte Chemie (International ed. in English)》2018,57(41):13382-13392
A large German research consortium mainly within the Max Planck Society (“MaxSynBio”) was formed to investigate living systems from a fundamental perspective. The research program of MaxSynBio relies solely on the bottom‐up approach to synthetic biology. MaxSynBio focuses on the detailed analysis and understanding of essential processes of life through modular reconstitution in minimal synthetic systems. The ultimate goal is to construct a basic living unit entirely from non‐living components. The fundamental insights gained from the activities in MaxSynBio could eventually be utilized for establishing a new generation of biotechnological processes, which would be based on synthetic cell constructs that replace the natural cells currently used in conventional biotechnology. 相似文献
148.
In vitro anti-tumour and anti-radical activities of the acetone extract of the freshwater sponge Ochridaspongia rotunda were the subject of this study. The extract was found to be highly cytotoxic to human lung tumour cell line A-549 reaching IC50 value of 5.01 ± 0.21 μg/mL. Indeed, it displayed only 2-fold less anti-tumour activity than doxorubicin (IC50 value 2.42 ± 0.13 μg/mL) used as a positive control. The same extract was also found to be almost 37-fold more selective against A-549 vs. MRC-5 (normal) lung cells, in difference to weak selectivity of doxorubicin (less than 3-fold). Its profound anti-DPPH radical activity comparable to that of quercetin (IC50 values 3.68 ± 0.19 and 3.14 ± 0.09 μg/mL, respectively) coupled with no signs of genotoxicity in the comet assay (MRC-5 cell line, vs. doxorubicin) has actually implicated the importance of this animal bioresource in searching for pharmaceutically useful bioactive compounds of natural origin. 相似文献
149.
Fabrication of Defined Polydopamine Nanostructures by DNA Origami‐Templated Polymerization
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Yu Tokura Sean Harvey Chaojian Chen Prof. Dr. Yuzhou Wu Dr. David Y. W. Ng Prof. Dr. Tanja Weil 《Angewandte Chemie (International ed. in English)》2018,57(6):1587-1591
A versatile, bottom‐up approach allows the controlled fabrication of polydopamine (PD) nanostructures on DNA origami. PD is a biosynthetic polymer that has been investigated as an adhesive and promising surface coating material. However, the control of dopamine polymerization is challenged by the multistage‐mediated reaction mechanism and diverse chemical structures in PD. DNA origami decorated with multiple horseradish peroxidase‐mimicking DNAzyme motifs was used to control the shape and size of PD formation with nanometer resolution. These fabricated PD nanostructures can serve as “supramolecular glue” for controlling DNA origami conformations. Facile liberation of the PD nanostructures from the DNA origami templates has been achieved in acidic medium. This presented DNA origami‐controlled polymerization of a highly crosslinked polymer provides a unique access towards anisotropic PD architectures with distinct shapes that were retained even in the absence of the DNA origami template. 相似文献
150.
Kornauth Wilh Bersch A. Philips Christ. Kob und Co. Donner Louise H. Weller C. Schweitzer Ch. L. Penny Ed. van Melckebeke H. J. Wheeler B. Hartwell Knorr W. Büttner Barthé W. Jerwitz C. F. Parker Gust Christ Ferdinand Kryz J. Katz H. Göckel R. Jabota J. J. L. von Rijn F. Baum Joseph Nerking A. E. Taylor J. Gadamer C. Th. L. Hagemann und C. A. Neufeld 《Fresenius' Journal of Analytical Chemistry》1902,41(11):686-695
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