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991.
Chai XY Sun JF Tang LY Yang XW Li YQ Huang H Zhou XF Yang B Liu Y 《Chemical & pharmaceutical bulletin》2010,58(10):1391-1394
A chemical investigation on a South China Sea gorgonian, Menella sp. resulted in the isolation and elucidation of menellin A (1), a highly oxygenated racemate with C(8) skeleton, and a polyhydroxylated steroid, menellsteroid C (2), along with eight known compounds (3-10). The structures of the new compounds were elucidated by means of MS, 1D and 2D NMR spectra, and the relative stereochemistry of 1 was determined by X-ray single-crystal diffraction analysis. In addition, compound 7 was isolated as a new natural product. Compounds 1-3 and 7 were selected to test the anti-inflammatory inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages. 1 and 3 exhibited modest inhibitory effects with IC(50) of 71.3, 33.9 μM, respectively, compared to the positive control aminoguanidine (IC(50) 25.0 μM). 相似文献
992.
Dimethylsilyl (DMS) modified mesoporous silicas were successfully prepared via co-condensation and post-grafting modification methods. The post-grafting modification was carried out by the reaction of the as-synthesized MCM-41 material (before CTAB removal) with diethoxydimethylsinale (DEDMS). N2 adsorption-desorption and 29Si MAS NMR characterization demonstrated that different amount of DMS groups were successfully incorporated into the co-condensation modified samples, and the functional DMS groups were placed selectively on the pore openings and external pore surfaces in the post-grafting modified samples. Subsequently, the controlled drug delivery properties from the resulting DMS-modified mesoporous silicas were investigated in detail. The drug adsorption experiments showed that the adsorption capacities were mainly depended on the content of silanol group (CSG) in the corresponding carriers. The in vitro tests exhibited that the incorporation of DMS groups greatly retarded the ibuprofen release rate. Moreover, the ibuprofen release profiles could be well modulated by varying DMS modification levels and site-selective distribution of functional groups in mesoporous carriers. 相似文献
993.
Xiao-Yu Tang Bin Wu Han-Jie Ying Bing-Fang He 《Applied biochemistry and biotechnology》2010,160(4):1017-1031
An organic solvent-stable protease from Pseudomonas aeruginosa PT121 was purified in a single step with 55% recovery by hydrophobic interaction chromatography on a Phenyl Sepharose High
Performance matrix. The purified protease was homogenous on SDS-PAGE and had an estimated molecular mass of 33 kDa. The optimal
pH and temperature conditions for enzyme activity were 8.0 and 60°C, respectively. The enzyme was classified as a metalloprotease
based on its strong inhibition by EDTA and 1,10-phenanthroline and exhibited good stability across a broad pH range (6.0–11.0).
The protease was quite stable in the presence of various water-miscible organic solvents. This is a unique property of the
protease which makes it an ideal choice for application in aqueous-organic phase organic synthesis including peptides synthesis.
The synthetic activity of the protease was tested using N-carbobenzoxy-l-asparagine (Z-Asp) and l-phenylalaninamide (Phe-NH2) as substrate in the presence of various water-miscible organic solvents for aspartame precursor synthesis. The highest yield
was obtained in the presence of 50% DMSO (91%). The synthesis rate in the presence of DMSO was also much higher than the rates
in the other tested organic solvents, and the initial rates of Z-Asp-Phe-NH2 synthesis in mixtures of various water-miscible organic solvents, with the exception of ethanol, correlated with the yields
of Z-Asp-Phe-NH2. Furthermore, the PT121 protease was able to use various carboxyl components (Z-AA) and Phe-NH2 as substrates to catalyze the syntheses of the dipeptides, indicating that this protease has a broad specificity for carboxylic
acid residue. 相似文献
994.
Ying Tang Chaomei Xiong Daonian Zhou Anhua Wei Wei Fu Yaling Cai Jinlan Ruan 《Chemistry of Natural Compounds》2010,46(2):209-211
A new flavonoid, 5,7-dihydroxy-2-(1-hydroxy-2,6-dimethoxy-4-oxo-cyclohex)-chromen-4-one (1), was isolated from the roots of Macrothelypteris torresiana (Gaud.) Ching. (Thelypteridaceae). The structure of the product was identified on the basis of detailed spectral analysis,
including X-ray structure analysis. 相似文献
995.
Variable-weighted least-squares support vector machine for multivariate spectral analysis 总被引:1,自引:0,他引:1
Multivariate spectral analysis has been widely applied in chemistry and other fields. Spectral data consisting of measurements at hundreds and even thousands of analytical channels can now be obtained in a few seconds. It is widely accepted that before a multivariate regression model is built, a well-performed variable selection can be helpful to improve the predictive ability of the model. In this paper, the concept of traditional wavelength variable selection has been extended and the idea of variable weighting is incorporated into least-squares support vector machine (LS-SVM). A recently proposed global optimization method, particle swarm optimization (PSO) algorithm is used to search for the weights of variables and the hyper-parameters involved in LS-SVM optimizing the training of a calibration set and the prediction of an independent validation set. All the computation process of this method is automatic. Two real data sets are investigated and the results are compared those of PLS, uninformative variable elimination-PLS (UVE-PLS) and LS-SVM models to demonstrate the advantages of the proposed method. 相似文献
996.
Calcium titanate (CaTiO3) was conveniently synthesized by thermal decomposition of a single-source precursor [Ca(H2O)3]2[Ti2(O2)2O(NC6H6O6)2]·2H2O at low temperature. This single-source precursor was characterized by elemental analysis, IR spectrum, thermal gravimetric analysis and X-ray single crystal diffraction. The calcined products at different temperature were further characterized by powder X-ray diffractions and IR spectra. The morphology, microstructure, and crystallinity of the resulting CaTiO3 materials have been characterized by SEM and TEM. The BET measurement revealed that the CaTiO3 powders had a surface area of 14.0 m2/g. In addition, the microwave dielectric properties of the resulting CaTiO3 material have been measured. 相似文献
997.
Bi-Yu Tang Dong-Lin Li Ping Chen Jian-Xiong Yi Li Wen Li-Ming Peng Wen-Jiang Ding 《Solid State Sciences》2010,12(5):845-850
Ab initio density functional theory (DFT) and density function perturbation theory (DFPT) have been used to investigate the thermal properties of the Al–Mg–Sc, Al–Mg–Zr and Al–Mg–Sc–Zr alloys over a wide range of temperature and pressure. Phonon dispersions are obtained at equilibrium and strained configurations by DFPT. Using the quasiharmonic approximation (QHA) for the free energy, several physical quantities of interest such as thermal Grüneisen parameter, heat capacity at constant pressure and at constant volume, thermal expansion coefficient, entropy, adiabatic bulk modulus and isothermal bulk modulus as a function of temperature and pressure are calculated and discussed. The present results show that the thermal expansion coefficient of the Al–Mg–Sc–Zr is far lower than that of Al–Mg–Sc and Al–Mg–Zr, and the variation features in the adiabatic bulk modulus and isothermal bulk modulus for the Al–Mg–Sc–Zr are also very different from that of Al–Mg–Sc and Al–Mg–Zr. 相似文献
998.
We describe a collinear velocity-map photoelectron imaging spectrometer, which combines a Wiley-McLaren time-of-flight mass analyzer with a dual-valve laser vaporization source for investigating size-selected cluster and reaction intermediate anions. To generate the reaction anions conveniently, two pulsed valves and a reaction channel are employed instead of premixing carrier gas. The collinear photoelectron imaging spectrometer adopts modified velocity-map electrostatic lens, and provides kinetic energy resolution better than 3%. The performance of the instrument is demonstrated on the photodetachment of Si4- at 532 and 355 nm, and Si3C- at 532 nm, respectively. In both cases, photoelectron spectra and anisotropy parameters are obtained from the images. For Si4-, the spectra show two well-resolved vibrational progressions which correspond to the ground state and the first excited state of the neutral Si4 with peak spacing of 330 and 312 cm-1, respectively. Preliminary results suggest that the apparatus is a powerful tool for characterizing the electronic structure and photodetachment dynamics of cluster anions. 相似文献
999.
Qinghu Tang Yuanting Chen Yanhui Yang 《Journal of molecular catalysis. A, Chemical》2010,315(1):43-50
Vanadium oxide catalysts supported on activated carbon (V/AC) with V loadings ranging from 1 to 20 wt.% were prepared by a wet-impregnation method. Various physicochemical characterization techniques, including nitrogen physisorption, X-ray diffraction (XRD), Raman spectroscopy, X-ray absorption (XANES and EXAFS), X-ray photoelectron spectroscopy (XPS), and electron spin resonance (ESR), were employed to understand the nature of vanadium species on activated carbon. The results revealed that vanadium oxide mainly existed in a highly dispersed state for 10 wt.% or less vanadium loadings; a large amount of vanadium resulted in aggregated microcrystalline phase. Vanadium species on activated carbon surface showed a similar local coordination structure to that of NH4VO3 with a distorted tetrahedral symmetry at low vanadium loadings, whereas octahedral coordination was dominant at high vanadium loadings (>10 wt.%). All V/AC samples showed V5+ as the major oxidation state. Nevertheless, V4+ centered in a distorted tetrahedral symmetry could be detected at a vanadium loading greater than 4 wt.%. The catalytic activity for the benzyl alcohol oxidation largely depended on the dispersion, oxidation state, and local coordination of vanadium oxides on activated carbon. Highly dispersed vanadium (5+) species with a distorted tetrahedral coordination were postulated to account for the excellent catalytic performances of V/AC catalysts (TOF = 39.1 h?1). 相似文献
1000.
Serial analysis of gene expression (SAGE) is a powerful tool to obtain gene expression profiles. Clustering analysis is a valuable technique for analyzing SAGE data. In this paper, we propose an adaptive clustering method for SAGE data analysis, namely, PoissonAPS. The method incorporates a novel clustering algorithm, Affinity Propagation (AP). While AP algorithm has demonstrated good performance on many different data sets, it also faces several limitations. PoissonAPS overcomes the limitations of AP using the clustering validation measure as a cost function of merging and splitting, and as a result, it can automatically cluster SAGE data without user-specified parameters. We evaluated PoissonAPS and compared its performance with other methods on several real life SAGE datasets. The experimental results show that PoissonAPS can produce meaningful and interpretable clusters for SAGE data. 相似文献